页面 3 | Aurora激酶 - 表观遗传学 - 按“信号通路”分类

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KW-2449,抑制FLT3，ABL和Aurora激酶

规格或纯度 :

Moligand™

≥98%

CAS号: 1000669-72-6

分子式: C₂₀H₂₀N₄O 分子量: 332.4

IUPAC Name: [4-[(E)-2-(1H-indazol-3-yl)ethenyl]phenyl]-piperazin-1-ylmethanone

SMILES: C1CN(CCN1)C(=O)C2=CC=C(C=C2)C=CC3=NNC4=CC=CC=C43

InChIKey: YYLKKYCXAOBSRM-JXMROGBWSA-N

InChI: 1S/C20H20N4O/c25-20(24-13-11-21-12-14-24)16-8-5-15(6-9-16)7-10-19-17-3-1-2-4-18(17)22-23-19/h1-10,21H,11-14H2,(H,22,23)/b10-7+

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Alisertib (MLN8237)

规格或纯度 :

Moligand™

≥98%

CAS号: 1028486-01-2

分子式: C₂₇H₂₀ClFN₄O₄ 分子量: 518.94

IUPAC Name: 4-[[9-chloro-7-(2-fluoro-6-methoxyphenyl)-5H-pyrimido[5,4-d][2]benzazepin-2-yl]amino]-2-methoxybenzoic acid

SMILES: COC1=C(C(=CC=C1)F)C2=NCC3=CN=C(N=C3C4=C2C=C(C=C4)Cl)NC5=CC(=C(C=C5)C(=O)O)OC

InChIKey: ZLHFILGSQDJULK-UHFFFAOYSA-N

InChI: 1S/C27H20ClFN4O4/c1-36-21-5-3-4-20(29)23(21)25-19-10-15(28)6-8-17(19)24-14(12-30-25)13-31-27(33-24)32-16-7-9-18(26(34)35)22(11-16)37-2/h3-11,13H,12H2,1-2H3,(H,34,35)(H,31,32,33)

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头孢曲松

规格或纯度 :

Moligand™

≥95%

CAS号: 73384-59-5

分子式: C₁₈H₁₈N₈O₇S₃ 分子量: 554.58

IUPAC Name: (6R,7R)-7-[[(2Z)-2-(2-amino-1,3-thiazol-4-yl)-2-methoxyiminoacetyl]amino]-3-[(2-methyl-5,6-dioxo-1H-1,2,4-triazin-3-yl)sulfanylmethyl]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid

SMILES: CN1C(=NC(=O)C(=O)N1)SCC2=C(N3C(C(C3=O)NC(=O)C(=NOC)C4=CSC(=N4)N)SC2)C(=O)O

InChIKey: VAAUVRVFOQPIGI-SPQHTLEESA-N

InChI: 1S/C18H18N8O7S3/c1-25-18(22-12(28)13(29)23-25)36-4-6-3-34-15-9(14(30)26(15)10(6)16(31)32)21-11(27)8(24-33-2)7-5-35-17(19)20-7/h5,9,15H,3-4H2,1-2H3,(H2,19,20)(H,21,27)(H,23,29)(H,31,32)/b24-8-/t9-,15-/See more

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Tripolin A,非ATP竞争性Aurora A和B抑制剂

规格或纯度 :

≥98%

CAS号: 1148118-92-6 Compound CID : 14685351

分子式: C₁₅H₁₁NO₃ 分子量: 253.25

IUPAC Name: (3Z)-3-[(2,5-dihydroxyphenyl)methylidene]-1H-indol-2-one

SMILES: C1=CC=C2C(=C1)C(=CC3=C(C=CC(=C3)O)O)C(=O)N2

InChIKey: OMKSBDLWMROKNU-WQLSENKSSA-N

InChI: 1S/C15H11NO3/c17-10-5-6-14(18)9(7-10)8-12-11-3-1-2-4-13(11)16-15(12)19/h1-8,17-18H,(H,16,19)/b12-8-

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NU 6140,Cdk2抑制剂

规格或纯度 :

Moligand™

≥98%

CAS号: 444723-13-1

分子式: C₂₃H₃₀N₆O₂ 分子量: 422.52

IUPAC Name: 4-[[6-(cyclohexylmethoxy)-7H-purin-2-yl]amino]-N,N-diethylbenzamide

SMILES: CCN(CC)C(=O)C1=CC=C(C=C1)NC2=NC3=C(C(=N2)OCC4CCCCC4)NC=N3

InChIKey: XHEQSRJCJTWWAH-UHFFFAOYSA-N

InChI: 1S/C23H30N6O2/c1-3-29(4-2)22(30)17-10-12-18(13-11-17)26-23-27-20-19(24-15-25-20)21(28-23)31-14-16-8-6-5-7-9-16/h10-13,15-16H,3-9,14H2,1-2H3,(H2,24,25,26,27,28)

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盐酸巴马汀

规格或纯度 :

Moligand™

≥98%

CAS号: 10605-02-4 Compound CID : 73442

分子式: C₂₁H₂₂ClNO₄ 分子量: 387.86

IUPAC Name: 2,3,9,10-tetramethoxy-5,6-dihydroisoquinolino[2,1-b]isoquinolin-7-ium;chloride

SMILES: COC1=C(C2=C[N+]3=C(C=C2C=C1)C4=CC(=C(C=C4CC3)OC)OC)OC.[Cl-]

InChIKey: RLQYRXCUPVKSAW-UHFFFAOYSA-M

InChI: 1S/C21H22NO4.ClH/c1-23-18-6-5-13-9-17-15-11-20(25-3)19(24-2)10-14(15)7-8-22(17)12-16(13)21(18)26-4;/h5-6,9-12H,7-8H2,1-4H3;1H/q+1;/p-1

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TC-A 2317 盐酸盐

规格或纯度 :

≥98%(HPLC)

CAS号: 1245907-03-2 Compound CID : 46911725

分子式: C₁₉H₂₈N₆O.HCl 分子量: 392.93

IUPAC Name: 2-[(6-hydroxy-6-methylheptan-2-yl)amino]-4-methyl-6-[(5-methyl-1H-pyrazol-3-yl)amino]pyridine-3-carbonitrile;hydrochloride

SMILES: CC1=CC(=NC(=C1C#N)NC(C)CCCC(C)(C)O)NC2=NNC(=C2)C.Cl

InChIKey: DXVATYHPJJPMIN-UHFFFAOYSA-N

InChI: 1S/C19H28N6O.ClH/c1-12-9-16(22-17-10-14(3)24-25-17)23-18(15(12)11-20)21-13(2)7-6-8-19(4,5)26;/h9-10,13,26H,6-8H2,1-5H3,(H3,21,22,23,24,25);1H

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甘氨酰-H 1152 二盐酸盐

规格或纯度 :

≥99%(HPLC)

CAS号: 913844-45-8 Compound CID : 56972177

分子式: C₁₈H₂₄N₄O₃S•2HCl 分子量: 449.4

IUPAC Name: 2-amino-1-[(3S)-3-methyl-4-(4-methylisoquinolin-5-yl)sulfonyl-1,4-diazepan-1-yl]ethanone;dihydrochloride

SMILES: CC1CN(CCCN1S(=O)(=O)C2=CC=CC3=C2C(=CN=C3)C)C(=O)CN.Cl.Cl

InChIKey: ILDBNQGLZFSHQZ-UTLKBRERSA-N

InChI: 1S/C18H24N4O3S.2ClH/c1-13-10-20-11-15-5-3-6-16(18(13)15)26(24,25)22-8-4-7-21(12-14(22)2)17(23)9-19;;/h3,5-6,10-11,14H,4,7-9,12,19H2,1-2H3;2*1H/t14-;;/m0../s1

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Aurora Kinase Inhibitor II

规格或纯度 :

Moligand™

≥90%

CAS号: 331770-21-9

分子式: C₂₃H₂₀N₄O₃ 分子量: 400.4

IUPAC Name: N-[4-[(6,7-dimethoxyquinazolin-4-yl)amino]phenyl]benzamide

SMILES: COC1=C(C=C2C(=C1)C(=NC=N2)NC3=CC=C(C=C3)NC(=O)C4=CC=CC=C4)OC

InChIKey: IMYVCWQAHSYYOO-UHFFFAOYSA-N

InChI: 1S/C23H20N4O3/c1-29-20-12-18-19(13-21(20)30-2)24-14-25-22(18)26-16-8-10-17(11-9-16)27-23(28)15-6-4-3-5-7-15/h3-14H,1-2H3,(H,27,28)(H,24,25,26)

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MK-8745

规格或纯度 :

≥98%

CAS号: 885325-71-3

分子式: C₂₀H₁₉ClFN₅OS 分子量: 431.91

IUPAC Name: (3-chloro-2-fluorophenyl)-[4-[[6-(1,3-thiazol-2-ylamino)pyridin-2-yl]methyl]piperazin-1-yl]methanone

SMILES: C1CN(CCN1CC2=NC(=CC=C2)NC3=NC=CS3)C(=O)C4=C(C(=CC=C4)Cl)F

InChIKey: YCRFPWKUUNKNDN-UHFFFAOYSA-N

InChI: 1S/C20H19ClFN5OS/c21-16-5-2-4-15(18(16)22)19(28)27-10-8-26(9-11-27)13-14-3-1-6-17(24-14)25-20-23-7-12-29-20/h1-7,12H,8-11,13H2,(H,23,24,25)

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极光激酶抑制剂III

规格或纯度 :

Moligand™

≥95%

CAS号: 879127-16-9

分子式: C₂₁H₁₈F₃N₅O 分子量: 413.4

IUPAC Name: N-[3-[[4-[3-(trifluoromethyl)anilino]pyrimidin-2-yl]amino]phenyl]cyclopropanecarboxamide

SMILES: C1CC1C(=O)NC2=CC=CC(=C2)NC3=NC=CC(=N3)NC4=CC=CC(=C4)C(F)(F)F

InChIKey: RDTDWGQDFJPTPD-UHFFFAOYSA-N

InChI: 1S/C21H18F3N5O/c22-21(23,24)14-3-1-4-15(11-14)26-18-9-10-25-20(29-18)28-17-6-2-5-16(12-17)27-19(30)13-7-8-13/h1-6,9-13H,7-8H2,(H,27,30)(H2,25,26,28,29)

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CCT241736

CAS号: 1402709-93-6

分子式: C₂₂H₂₃Cl₂N₇ 分子量: 456.4

IUPAC Name: 6-chloro-7-[4-[(4-chlorophenyl)methyl]piperazin-1-yl]-2-(1,3-dimethylpyrazol-4-yl)-1H-imidazo[4,5-b]pyridine

SMILES: CC1=NN(C=C1C2=NC3=NC=C(C(=C3N2)N4CCN(CC4)CC5=CC=C(C=C5)Cl)Cl)C

InChIKey: AKJBLKUZXRMECW-UHFFFAOYSA-N

InChI: 1S/C22H23Cl2N7/c1-14-17(13-29(2)28-14)21-26-19-20(18(24)11-25-22(19)27-21)31-9-7-30(8-10-31)12-15-3-5-16(23)6-4-15/h3-6,11,13H,7-10,12H2,1-2H3,(H,25,26,27)

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