| 货号 (SKU) | 包装规格 | 是否现货 | 价格 | 数量 |
|---|---|---|---|---|
| B656774-1ml |
1ml |
期货  |
|
| 别名 | BGC-20-1531 游离碱 |
|---|---|
| 规格或纯度 | 10mM in DMSO |
| 英文名称 | BGC-20-1531 free base |
| 生化机理 | BGC-20-1531 (PGN 1531) 游离碱是一种强效、选择性的类前列腺素 EP 4 受体拮抗剂，pK B 为 7.6。BGC-20-1531 游离碱具有研究偏头痛的潜力。 |
| 储存温度 | -80℃储存 |
| 运输条件 | 超低温冰袋运输 |
| 产品介绍 |
BGC-20-1531 (PGN 1531) free base is a potent and selective prostanoid EP 4 receptor antagonist, with a pK B of 7.6. BGC-20-1531 free base has the potential for the research of migraine headache In Vitro BGC-20-1531 free base competitively antagonized PGE 2 -induced vasodilatation of human middle cerebral (pK b =7.8) and meningeal (pK b =7.6) arteries, but had no effect on responses induced by PGE 2 on coronary, pulmonary or renal arteries. MCE has not independently confirmed the accuracy of these methods. They are for reference only. In Vivo BGC-20-1531 free base (1-10 mg/kg; i.v.) causes a dose-dependent antagonism of the PGE 2 -induced increase in canine carotid blood flow . MCE has not independently confirmed the accuracy of these methods. They are for reference only. Animal Model: Beagle dogs Dosage: 1-10 mg/kg Administration: I.v. Result: Caused a dose-dependent antagonism of the PGE 2 -induced increase in canine carotid blood flow. IC50& Target:EP4 7.6 (pKd) |
| 分子类型 | 小分子 |
|---|---|
| Canonical SMILES | CC1=CC=CC=C1S(=O)(=O)NC(=O)C2=CC(=C(O2)C)COC3=CC=C(C=C3)C4=NC=C(C=C4)OC |
| 分子量 | 492.54 |
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