| 货号 (SKU) | 包装规格 | 是否现货 | 价格 | 数量 |
|---|---|---|---|---|
| B421846-1ml |
1ml |
现货  |
|
| 英文别名 | Benzamide,4-(acetylamino)-N-(2-amino-4-fluorophenyl)- |
|---|---|
| 规格或纯度 | 10mM in DMSO |
| 英文名称 | BRD3308 |
| 生化机理 | BRD3308 是一种强效、高选择性的 HDAC3 抑制剂，对 HDAC3、HDAC1 和 HDAC2 的 IC50 分别为 54 nM、1.26 μM 和 1.34 μM。BRD3308 可激活 HIV-1 的转录。BRD3308 可抑制炎性细胞因子（糖脂毒性应激）诱导的胰腺 β 细胞凋亡，并增加功能性胰岛素的释放。 |
| 储存温度 | 避光,-80℃储存 |
| 运输条件 | 超低温冰袋运输 |
| 产品介绍 |
Information BRD3308 is a potant and highly selective inhibitor ofHDAC3with IC50 of 54 nM, 1.26 μM and 1.34 μM for HDAC3, HDAC1 and HDAC2, respectively. BRD3308 activates HIV-1 transcription. BRD3308 suppresses pancreatic β-cell apoptosis induced by inflammatory cytokines (glucolipotoxic stress) and increases functional insulin release. Targets HDAC3 (Cell-free assay); HDAC1 (Cell-free assay); HDAC2 (Cell-free assay) 54 nM; 1.26 μM; 1.34 μM In vitro BRD3308 is a derivative of the ortho-aminoanilide HDAC inhibitor CI-994 and is developed to be highly selective for inhibition of HDAC3 with an IC50 value that is 23-fold lower for HDAC3 than for HDAC1 or 22. HDAC3 selective inhibition induces expression of HIV and exposure to BRD3308 allows the recovery of latent HIV-1 from patient cells. In vivo Selective inhibition of HDAC3 by BRD3308 prevents diabetes onset in female NOD mice. HDAC3 treatment in vivo prevents pancreatic islet infiltration and protects β-cells from apoptosis. β-cell proliferation is increased in animals treated with BRD3308. HDAC3 treatment in vivo prevents white adipose tissue infiltration in NOD mice. Cell Research(from reference) Cell lines：2D10 cells, J89 cells, THP89 cells, J-Lat 6.3 cells Concentrations：5 μM, 10 μM, 15 μM, 30 μM Incubation Time：6 h, 12 h, 18 h, 24 h |
| 作用机制 | Action Type | target ID | Target Name | Target Type | Target Organism | Binding Site Name | 参考文献 |
|---|
| 分子类型 | 小分子 |
|---|---|
| IUPAC Name | 4-acetamido-N-(2-amino-4-fluorophenyl)benzamide |
| INCHI | InChI=1S/C15H14FN3O2/c1-9(20)18-12-5-2-10(3-6-12)15(21)19-14-7-4-11(16)8-13(14)17/h2-8H,17H2,1H3,(H,18,20)(H,19,21) |
| InChi Key | RRJDFENBXIEAPD-UHFFFAOYSA-N |
| Canonical SMILES | CC(=O)NC1=CC=C(C=C1)C(=O)NC2=C(C=C(C=C2)F)N |
| Isomeric SMILES | CC(=O)NC1=CC=C(C=C1)C(=O)NC2=C(C=C(C=C2)F)N |
| PubChem CID | 72734382 |
| 分子量 | 287.29 |
| 敏感性 | 对光线敏感 |
|---|---|
| 分子量 | 287.290 g/mol |
| XLogP3 | 1.400 |
| 氢键供体数Hydrogen Bond Donor Count | 3 |
| 氢键受体数Hydrogen Bond Acceptor Count | 4 |
| 可旋转键计数Rotatable Bond Count | 3 |
| 精确质量Exact Mass | 287.107 Da |
| 单同位素质量Monoisotopic Mass | 287.107 Da |
| 拓扑极表面积Topological Polar Surface Area | 84.200 Ų |
| 重原子数Heavy Atom Count | 21 |
| 形式电荷Formal Charge | 0 |
| 复杂度Complexity | 383.000 |
| 同位素原子数Isotope Atom Count | 0 |
| 定义的原子立体中心计数Defined Atom Stereocenter Count | 0 |
| 未定义的原子立体中心计数Undefined Atom Stereocenter Count | 0 |
| 定义的键立体中心计数Defined Bond Stereocenter Count | 0 |
| 未定义的键立体中心计数Undefined Bond Stereocenter Count | 0 |
| 所有立体化学键的总数The total count of all stereochemical bonds | 0 |
| 共价键合单元计数Covalently-Bonded Unit Count | 1 |
| RIDADR | NONHforallmodesoftransport |
|---|
| Concentration(Compounding value) | 9.0-11.0(mmol/L) |
|---|---|
| Appearance(Light yellow liquid) | pass |
| Record the entire process by video | Conform |
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