产品名称	Abbvie patent anti-TNFRSF21 (anti-TNFRSF21)
别名	TNFRSF21抗体 \| TNFRSF21单克隆抗体 \| TNFRSF21药靶抗体
英文别名	TNFRSF 21 antibody \| BM 018 antibody \| BM018 antibody \| CD358 antibody \| Death receptor 6 antibody \| DR 6 antibody \| DR6 antibody \| MGC31965 antibody \| OTTHUMP00000039915 antibody \| TNFR related death receptor 6 antibody \| TNFRSF21 antibody \| TNFRSF21 pro
规格或纯度	无载体, 重组, ExactAb™, 低内毒素, 无叠氮钠, 已验证, 无动物源, ≥95%(SDS-PAGE&SEC-HPLC), 见COA
生化机理	可能激活 NF-kappa-B，促进细胞凋亡。可能激活 JNK 并参与 T 细胞分化。正常细胞体死亡和轴突修剪都需要它。营养因子缺乏会引发β-分泌酶裂解表面APP，释放出sAPP-beta，sAPP-beta进一步被裂解，释放出APP的N-末端片段（N-APP）。N-APP 可与 TNFRSF21 结合，触发 caspase 激活，并导致神经元细胞体（通过 caspase-3）和轴突（通过 caspase-6）变性。
宿主种属	人(Human)
特异性	TNFRSF21
种属反应性	人(Human),大鼠(Rat)
偶联	Unconjugated

产品属性

克隆类型	重组抗体
Format	Whole IgG
亚型	Human IgG1
轻链亚型	kappa
SDS-PAGE	150 kDa
纯化方法	Protein A purified
储存缓冲液	Supplied as a 0.22μm filtered solution in 100mM Pro-Ac, 20mM Arg, pH 5.0
防腐剂	No
浓度	见COA
储存温度	-80℃储存,避免反复冻融
运输条件	超低温冰袋运输
稳定性与储存	在 -80℃ 下保存 24 个月。收货后建议分装。避免冷冻/解冻循环。
分子类型	抗体

图片

Flow Cytometry: Abbvie patent anti-TNFRSF21 (anti-TNFRSF21) (Ab209901)

Abbvie patent anti-TNFRSF21 (anti-TNFRSF21) (Ab209901) - Flow Cytometry
Flow Cytometry analysis of A431 cells labelling TNFRSF21 (red) with Abbvie patent anti-TNFRSF21 (anti-TNFRSF21) (Ab209901) at 1.0 μg/mL for 1 hour at 4°C. Goat Anti-Human IgG (PE) (Ab175838) at a dilution of 1/1000 was used as the secondary antibody. Blue - Isotype control, human IgG (Ab170213). Black - Unlabelled control, cells without incubation with primary antibody.

Flow Cytometry: Abbvie patent anti-TNFRSF21 (anti-TNFRSF21) (Ab209901)

Abbvie patent anti-TNFRSF21 (anti-TNFRSF21) (Ab209901) - Flow Cytometry
Flow Cytometry analysis of Raji cells labelling TNFRSF21 (red) with Abbvie patent anti-TNFRSF21 (anti-TNFRSF21) (Ab209901) at 1.0 μg/mL for 1 hour at 4°C. Goat Anti-Human IgG (PE) (Ab175838) at a dilution of 1/1000 was used as the secondary antibody. Blue - Isotype control, human IgG (Ab170213). Black - Unlabelled control, cells without incubation with primary antibody.

Flow Cytometry: Abbvie patent anti-TNFRSF21 (anti-TNFRSF21) (Ab209901)

Abbvie patent anti-TNFRSF21 (anti-TNFRSF21) (Ab209901) - Flow Cytometry
Flow Cytometry analysis of huDR6-FL-HEK293-A6 cells labelling TNFRSF21 at 1×105 cell/well can bind Abbvie patent anti-TNFRSF21 (anti-TNFRSF21) (Ab209901), with the EC₅₀ is 0.593 nM.

SEC: Abbvie patent anti-TNFRSF21 (anti-TNFRSF21) (Ab209901)

Abbvie patent anti-TNFRSF21 (anti-TNFRSF21) (Ab209901) - SEC
The purity of Abbvie patent anti-TNFRSF21 (anti-TNFRSF21) (Ab209901) is more than 95% verified by HPLC.

关联靶点（人）

TNFRSF21 Tbio 肿瘤坏死因子受体超家族成员 21(Tumor necrosis factor receptor superfamily member 21) (0 活性数据)

点击查看靶蛋白信息： TNFRSF21