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抗体
单克隆抗体
Integrin beta 3/CD61 Mouse mAb (Biotin)

Integrin beta 3/CD61 Mouse mAb (Biotin)

已验证

ExactAb™

0.5 mg/mL

应用:

Flow Cytometry

功能和特点

宿主种属: 小鼠(Mouse)
种属反应性: 人(Human)
亚型: Mouse IgG1
克隆号: HIP11
偶联: Biotin

有货

库存信息

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库存信息

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库存信息

关闭

货号 (SKU)	包装规格	是否现货
Ab186826-10μg	10μg	现货
Ab186826-25μg	25μg	现货
Ab186826-100μg	100μg	现货

查看相关系列

点击查看靶蛋白信息: ITGB3

Accession#:P05106 (9) BDPLT16 (6) BDPLT2 (6) BDPLT24 (3) CD61 (7) Gene ID:3690 (9) GP3A (3) GPIIIa (3) GT (6) GT2 (3) ITGB3 (9) 生物素 (221)

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基本信息

产品名称	Integrin beta 3/CD61 Mouse mAb (Biotin)
别名	整合素β3/CD61抗体 \| CD61单抗
英文别名	BDPLT16 \| BDPLT2 \| BDPLT24 \| GPIIIa \| GT \| GT2 \| CD61 antigen \| CD61 \| GP3A \| GP3Aplatelet glycoprotein IIIa \| GPIIIaintegrin beta-3 \| INGRB3 \| Integrin beta 3 \| integrin, beta 3 (platelet glycoprotein IIIa, antigen CD61) \| ITG B3 \| ITGB3 \| Platelet membr
规格或纯度	ExactAb™, 已验证, 0.5 mg/mL
生化机理	Integrin alpha-V/beta-3 is a receptor for cytotactin, fibronectin, laminin, matrix metalloproteinase-2, osteopontin, osteomodulin, prothrombin, thrombospondin, vitronectin and von Willebrand factor. Integrin alpha-IIb/beta-3 is a receptor for fibronectin, fibrinogen, plasminogen, prothrombin, thrombospondin and vitronectin. Integrins alpha-IIb/beta-3 and alpha-V/beta-3 recognize the sequence R-G-D in a wide array of ligands. Integrin alpha-IIb/beta-3 recognizes the sequence H-H-L-G-G-G-A-K-Q-A-G-D-V in fibrinogen gamma chain. Following activation integrin alpha-IIb/beta-3 brings about platelet/platelet interaction through binding of soluble fibrinogen. This step leads to rapid platelet aggregation which physically plugs ruptured endothelial surface. In case of HIV-1 infection, the interaction with extracellular viral Tat protein seems to enhance angiogenesis in Kaposi's sarcoma lesions.
宿主种属	小鼠(Mouse)
特异性	Integrin beta 3
种属反应性	人(Human)
免疫原	Normal peripheral blood platelets and platelets from IPT patients
阳性对照	Flow Cytometry: human peripheral blood platelets
偶联	Biotin

产品属性

克隆类型	单克隆抗体
Format	Whole IgG
轻链亚型	kappa
纯化方法	Protein A purified
储存缓冲液	Liquid in PBS pH 7.4, containing 1% BSA and 0.05% Proclin300.
防腐剂	0.05% Proclin300
浓度	0.5 mg/mL
储存温度	2-8°C储存,避光,禁止冻结
运输条件	冰袋运输
稳定性与储存	The antibody solution should be stored undiluted between 2°C and 8°C, and protected from prolonged exposure to light. Do not freeze.
分子类型	抗体

图片

Flow Cytometry: Integrin beta 3/CD61 Mouse mAb (Biotin) (Ab186826)

Integrin beta 3/CD61 Mouse mAb (Biotin) (Ab186826) - Flow Cytometry
Flow cytometry analysis of Integrin beta 3/CD61 expression by human peripheral blood platelets (red) compared to an isotype control (blue). Cells were stained with Integrin beta 3/CD61 Mouse mAb (Biotin) (Ab186826) at 0.012μg/test for 1 hour at 4°C. Then incubated with Recombinant Streptavidin Protein (R-PE) (rp156150) at 0.1μg/test for 30 minutes at 4°C in the dark. Blue - Mouse IgG (Biotin) (Ab180306). Black - Unlabelled control, cells without incubation with primary antibody.

关联靶点（人）

ITGB3 Tclin 整合素β-3(Integrin beta-3) (0 活性数据)

点击查看靶蛋白信息： ITGB3

活性类型	活性值-log(M)	作用机制	期刊	参考文献(PubMed IDs)

安全和危险性（GHS）

应用

应用名称	稀释比例
Flow Cytometry	≤1.0μg/ test For flow cytometric staining, the suggested use of this reagent is ≤1.0 μg per million cells in 100 µL staining volume.