| 货号 (SKU) | 包装规格 | 是否现货 | 价格 | 数量 |
|---|---|---|---|---|
| Ab183317-100μg |
100μg |
现货  |
| |
| Ab183317-1mg |
1mg |
现货 |
| |
| Ab183317-5mg |
5mg |
现货 |
| |
| Ab183317-10mg |
10mg |
期货 |
|
| 产品名称 | Disitamab vedotin (anti-HER2) |
|---|---|
| 别名 | 维迪西妥单抗 |
| 英文别名 | Verb b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog antibody | C erb B2/neu protein antibody | CD340 antibody | CD340 antigen antibody | Cerb B2/neu protein antibody | CerbB2 antibody | Erb b2 receptor tyr |
| 规格或纯度 | 无载体, 重组, ExactAb™, 低内毒素, 无叠氮钠, 已验证, 无动物源, ≥90%(SDS-PAGE&SEC-HPLC), 见COA |
| 生化机理 | Protein tyrosine kinase that is part of several cell surface receptor complexes, but that apparently needs a coreceptor for ligand binding. Essential component of a neuregulin-receptor complex, although neuregulins do not interact with it alone. GP30 is a potential ligand for this receptor. Regulates outgrowth and stabilization of peripheral microtubules (MTs). Upon ERBB2 activation, the MEMO1-RHOA-DIAPH1 signaling pathway elicits the phosphorylation and thus the inhibition of GSK3B at cell membrane. This prevents the phosphorylation of APC and CLASP2, allowing its association with the cell membrane. In turn, membrane-bound APC allows the localization of MACF1 to the cell membrane, which is required for microtubule capture and stabilization. In the nucleus is involved in transcriptional regulation. Associates with the 5'-TCAAATTC-3' sequence in the PTGS2/COX-2 promoter and activates its transcription. Implicated in transcriptional activation of CDKN1A; the function involves STAT3 and SRC. Involved in the transcription of rRNA genes by RNA Pol I and enhances protein synthesis and cell growth. |
| 宿主种属 | 人(Human) |
| 特异性 | ERBB2 |
| 种属反应性 | 人(Human) |
| 偶联 | MC-VC-PAB-MMAE |
| 克隆类型 | 重组抗体 |
|---|---|
| Format | Whole IgG |
| 亚型 | Human IgG1 |
| 轻链亚型 | kappa |
| SDS-PAGE | 144.16 kDa |
| 纯化方法 | Protein A purified |
| 物理外观 | Liquid |
| 储存缓冲液 | Supplied as a 0.22μm filtered solution in 100mM Pro-Ac, 20mM Arg, pH 5.0 |
| 防腐剂 | No |
| 浓度 | 见COA |
| 储存温度 | -80℃储存,避免反复冻融 |
| 运输条件 | 超低温冰袋运输 |
| 稳定性与储存 | 在 -80℃ 下保存 24 个月。收货后建议分装。避免冷冻/解冻循环。 |
| CAS编号和信息 | 2136633-23-1 |
| 分子类型 | 抗体偶联药物 |
Disitamab vedotin (anti-HER2) (Ab183317) - Flow Cytometry
Flow Cytometry analysis of MCF7 cells labelling HER2 (red) with Disitamab vedotin (anti-HER2) (Ab183317) at 1.0 μg/mL for 1 hour at 4°C. Goat Anti-Human IgG (PE) (Ab175838) at a dilution of 1/1000 was used as the secondary antibody. Blue - Isotype control, human IgG (Ab170213). Black - Unlabelled control, cells without incubation with primary antibody.
Disitamab vedotin (anti-HER2) (Ab183317) - ELISA
Immobilized Recombinant Human HER2 protein (rp169607) at 1.0 μg/mL can bind Disitamab vedotin (anti-HER2) (Ab183317) with the EC50 of 53.58 ng/mL.
Disitamab vedotin (anti-HER2) (Ab183317) - SEC
The purity of Disitamab vedotin (anti-HER2) (Ab183317) is more than 95% verified by HPLC.
| 作用机制 | Action Type | target ID | Target Name | Target Type | Target Organism | Binding Site Name | 参考文献 |
|---|
通过匹配包装上的批号来查找并下载产品的 COA，每批产品都进行了严格的验证，您可放心使用！
| 批号(Lot Number) | 证书类型 | 日期 | 货号 |
|---|---|---|---|
 ZJ24F1216099 |
分析证书 | 24-12-26 | Ab183317 |
| ZJ24F1216100 |
分析证书 | 24-12-26 | Ab183317 |
| ZJ24F1216102 |
分析证书 | 24-12-26 | Ab183317 |
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