货号 (SKU)

包装规格

是否现货

价格

数量

Ab177929-100μg

100μg

现货

Ab177929-1mg

1mg

现货

Ab177929-5mg

5mg

现货

Ab177929-10mg

10mg

期货

基本信息

产品名称	Quetmolimab (anti-CX3CL1), Fractalkine 抑制剂
别名	喹莫单抗(抗 CX3CL1)
英文别名	CX3C membrane-anchored chemokine \| C-X3-C motif chemokine 1 \| Neurotactin \| Small-inducible cytokine D1
规格或纯度	无载体, 重组, ExactAb™, 低内毒素, 无叠氮钠, 已验证, 无动物源, ≥95%(SDS-PAGE&SEC-HPLC), 见COA
宿主种属	人(Human)
特异性	CX3CL1
种属反应性	人(Human),食蟹猴(Cynomolgus monkey)
偶联	Unconjugated
作用类型	抑制剂
作用机制	Fractalkine 抑制剂

产品属性

克隆类型	重组抗体
Format	Whole IgG
亚型	Human IgG2
轻链亚型	kappa
SDS-PAGE	26.2 kDa (Light Chain) & 50.8 kDa (Heavy Chain), under reducing conditions; 201.9 kDa, under non-reducing conditions.
纯化方法	Protein A purified
纯度	>95%
物理外观	Liquid
储存缓冲液	Supplied as a 0.22μm filtered solution in 100mM Pro-Ac, 20mM Arg, pH 5.0
防腐剂	No
浓度	见COA
储存温度	-80℃储存,避免反复冻融
运输条件	超低温冰袋运输
稳定性与储存	在 -80℃ 下保存 24 个月。收货后建议分装。避免冷冻/解冻循环。
CAS编号和信息	2084037-83-0
分子类型	抗体

图片

ELISA: Quetmolimab (anti-CX3CL1) (Ab177929)

Quetmolimab (anti-CX3CL1) (Ab177929) - ELISA
Immobilized Recombinant Human CX3CL1 Protein (rp144831) at 1.0 μg/mL can bind Quetmolimab (anti-CX3CL1) (Ab177929) with the EC₅₀ of 41.08 ng/mL.

SEC: Quetmolimab (anti-CX3CL1) (Ab177929)

Quetmolimab (anti-CX3CL1) (Ab177929) - SEC
The purity of Quetmolimab (anti-CX3CL1) (Ab177929) is more than 95% verified by HPLC.

关联靶点（人）

CX3CL1 Tbio 分形运动(Fractalkine) (0 活性数据)

点击查看靶蛋白信息： CX3CL1

活性类型	活性值-log(M)	作用机制	期刊	参考文献(PubMed IDs)

作用机制

作用机制	Action Type	target ID	Target Name	Target Type	Target Organism	Binding Site Name	参考文献

安全和危险性（GHS）

SDS英文版

质量标准

质量标准

质检证书（CoA,COO,BSE/TSE 和分析图谱)

C of A & Other Certificates(BSE/TSE, COO):

输入批号以搜索分析图谱:

通过匹配包装上的批号来查找并下载产品的 COA，每批产品都进行了严格的验证，您可放心使用！

找到5个结果

批号(Lot Number)	证书类型	日期	货号
ZJ24F1214921	分析证书	24-12-06	Ab177929
ZJ24F1214920	分析证书	24-12-06	Ab177929
ZJ24F1214919	分析证书	24-12-06	Ab177929
ZJ23F1202229	分析证书	23-12-26	Ab177929
ZJ23F1202230	分析证书	23-12-26	Ab177929

参考文献

1. Bazan JF, Bacon KB, Hardiman G, Wang W, Soo K, Rossi D, Greaves DR, Zlotnik A, Schall TJ. (1997) A new class of membrane-bound chemokine with a CX3C motif.. Nature, 385 (6617): (640-4). [PMID:9024663]
2. Timothy F Miles,Katja Spiess,Kevin M Jude,Naotaka Tsutsumi,John S Burg,Jessica R Ingram,Deepa Waghray,Gertrud M Hjorto,Olav Larsen,Hidde L Ploegh,Mette M Rosenkilde,K Christopher Garcia. (2018-06-09) Viral GPCR US28 can signal in response to chemokine agonists of nearly unlimited structural degeneracy.. eLife, 7 [PMID:29882741]
3. Pan, Y Y and 14 more authors.. (1997) Neurotactin, a membrane-anchored chemokine upregulated in brain inflammation.. Nature, (5): [PMID:9177350]
4. Mizoue, L S LS, Bazan, J F JF, Johnson, E C EC and Handel, T M TM.. (1999) Solution structure and dynamics of the CX3C chemokine domain of fractalkine and its interaction with an N-terminal fragment of CX3CR1.. Biochemistry, (2): [PMID:9931005]
5. Loftus, B J BJ and 18 more authors.. (1999) Genome duplications and other features in 12 Mb of DNA sequence from human chromosome 16p and 16q.. Genomics, (15): [PMID:10493829]
6. Hoover, D M DM, Mizoue, L S LS, Handel, T M TM and Lubkowski, J J.. (2000) The crystal structure of the chemokine domain of fractalkine shows a novel quaternary arrangement.. The Journal of biological chemistry, (28): [PMID:10770945]
7. Nishimura, Miyuki M and 8 more authors.. (2002) Dual functions of fractalkine/CX3C ligand 1 in trafficking of perforin+/granzyme B+ cytotoxic effector lymphocytes that are defined by CX3CR1 expression.. Journal of immunology (Baltimore, Md. : 1950), (15): [PMID:12055230]
8. Xue, Xiaoguang X and 8 more authors.. (2011) Structural basis of chemokine sequestration by CrmD, a poxvirus-encoded tumor necrosis factor receptor.. PLoS pathogens, [PMID:21829356]
9. Fujita, Masaaki M, Takada, Yoko K YK and Takada, Yoshikazu Y.. (2012) Integrins αvβ3 and α4β1 act as coreceptors for fractalkine, and the integrin-binding defective mutant of fractalkine is an antagonist of CX3CR1.. Journal of immunology (Baltimore, Md. : 1950), (15): [PMID:23125415]
10. Caballero-Campo, Pedro P and 5 more authors.. (2014) A role for the chemokine receptor CCR6 in mammalian sperm motility and chemotaxis.. Journal of cellular physiology, [PMID:23765988]
11. Fujita, Masaaki M, Takada, Yoko K YK and Takada, Yoshikazu Y.. (2014) The chemokine fractalkine can activate integrins without CX3CR1 through direct binding to a ligand-binding site distinct from the classical RGD-binding site.. PloS one, [PMID:24789099]
12. Burg, John S JS and 10 more authors.. (2015) Structural biology. Structural basis for chemokine recognition and activation of a viral G protein-coupled receptor.. Science (New York, N.Y.), (6): [PMID:25745166]
13. Hermand, Patricia P and 5 more authors.. (2016) Plasmodium falciparum proteins involved in cytoadherence of infected erythrocytes to chemokine CX3CL1.. Scientific reports, (22): [PMID:27653778]
14. Fong, A M and 6 more authors.. (1998) Fractalkine and CX3CR1 mediate a novel mechanism of leukocyte capture, firm adhesion, and activation under physiologic flow.. The Journal of experimental medicine, (19): [PMID:9782118]

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体积（添加到小瓶中）

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所需的复溶浓度

Quetmolimab (anti-CX3CL1), Fractalkine 抑制剂

库存信息

库存信息

库存信息

库存信息

基本信息

产品属性

图片

关联靶点（人）

作用机制

安全和危险性（GHS）

质量标准

质检证书（CoA,COO,BSE/TSE 和分析图谱)

参考文献

溶液计算器

摩尔浓度计算器

稀释计算器

复溶计算器

Quetmolimab (anti-CX3CL1), Fractalkine 抑制剂

库存信息

库存信息

库存信息

库存信息

基本信息

产品属性

图片

关联靶点（人）

作用机制

安全和危险性（GHS）

质量标准

质检证书（CoA,COO,BSE/TSE 和分析图谱)

相关产品

参考文献

溶液计算器

摩尔浓度计算器

稀释计算器

复溶计算器