产品名称	NGM621 (anti-Complement C3)
别名	NGM621（抗补体 C3）
英文别名	C3 and PZP-like alpha-2-macroglobulin domain-containing protein 1
规格或纯度	无载体, 重组, ExactAb™, 低内毒素, 无叠氮钠, 已验证, 无动物源, ≥95%(SDS-PAGE&SEC-HPLC), 见COA
宿主种属	人(Human)
特异性	C3
种属反应性	人(Human),食蟹猴(Cynomolgus monkey)
偶联	Unconjugated

产品属性

克隆类型	重组抗体
Format	Whole IgG
亚型	Human IgG1
轻链亚型	kappa
SDS-PAGE	144.9kDa
纯化方法	Protein A purified
纯度	>95%
物理外观	Liquid
储存缓冲液	Supplied as a 0.22μm filtered solution in 100mM Pro-Ac, 20mM Arg, pH 5.0
防腐剂	No
浓度	见COA
储存温度	-80℃储存,避免反复冻融
运输条件	超低温冰袋运输
稳定性与储存	在 -80℃ 下保存 24 个月。收货后建议分装。避免冷冻/解冻循环。
分子类型	抗体

图片

SEC: NGM621 (anti-Complement C3) (Ab177907)

NGM621 (anti-Complement C3) (Ab177907) - SEC
The purity of NGM621 (anti-Complement C3) (Ab177907) is more than 95% verified by HPLC.

关联靶点（人）

C3 Tclin 补体 C3(Complement C3) (0 活性数据)

点击查看靶蛋白信息： C3

活性类型	活性值-log(M)	作用机制	期刊	参考文献(PubMed IDs)

作用机制

作用机制	Action Type	target ID	Target Name	Target Type	Target Organism	Binding Site Name	参考文献

安全和危险性（GHS）

SDS英文版

质量标准

质量标准

质检证书（CoA,COO,BSE/TSE 和分析图谱)

C of A & Other Certificates(BSE/TSE, COO):

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找到3个结果

批号(Lot Number)	证书类型	日期	货号
ZJ24F0303093	分析证书	24-03-08	Ab177907
ZJ24F0303092	分析证书	24-03-08	Ab177907
ZJ24F0303091	分析证书	24-03-08	Ab177907

参考文献

1. Cain SA, Monk PN. (2002) The orphan receptor C5L2 has high affinity binding sites for complement fragments C5a and C5a des-Arg(74).. J Biol Chem, 277 (9): (7165-9). [PMID:11773063]
2. Kalant D, Cain SA, Maslowska M, Sniderman AD, Cianflone K, Monk PN. (2003) The chemoattractant receptor-like protein C5L2 binds the C3a des-Arg77/acylation-stimulating protein.. J Biol Chem, 278 (13): (11123-9). [PMID:12540846]
3. Kalant D, MacLaren R, Cui W, Samanta R, Monk PN, Laporte SA, Cianflone K. (2005) C5L2 is a functional receptor for acylation-stimulating protein.. J Biol Chem, 280 (25): (23936-44). [PMID:15833747]
4. Dzenita Smailhodzic,Freekje van Asten,Anna M Blom,Frida C Mohlin,Anneke I den Hollander,Johannes P H van de Ven,Ramon A C van Huet,Joannes M M Groenewoud,Yuan Tian,Tos T J M Berendschot,Yara T E Lechanteur,Sascha Fauser,Chris de Bruijn,Mohamed R Daha,Gert Jan van der Wilt,Carel B Hoyng,B Jeroen Klevering. (2014-11-14) Zinc supplementation inhibits complement activation in age-related macular degeneration.. PloS one, 9 ((11)): (e112682-e112682). [PMID:25393287]
5. Janssen BJ, Halff EF, Lambris JD, Gros P.. (2007) Structure of compstatin in complex with complement component C3c reveals a new mechanism of complement inhibition.. J Biol Chem, 282 (40): (29241-29247). [PMID:17684013] [10.1074/jbc.m704587200]
6. Gorham RD, Forest DL, Khoury GA, Smadbeck J, Beecher CN, Healy ED, Tamamis P, Archontis G, Larive CK, Floudas CA, Radeke MJ, Johnson LV, Morikis D.. (2015) New compstatin peptides containing N-terminal extensions and non-natural amino acids exhibit potent complement inhibition and improved solubility characteristics.. J Med Chem, 58 (2): (814-826). [PMID:25494040] [10.1021/jm501345y]
7. and Hugli, T E TE.. (1975) Human anaphylatoxin (C3a) from the third component of complement. Primary structure.. The Journal of biological chemistry, (10): [PMID:1238393]
8. Isaac, L L and Isenman, D E DE.. (1992) Structural requirements for thioester bond formation in human complement component C3. Reassessment of the role of thioester bond integrity on the conformation of C3.. The Journal of biological chemistry, (15): [PMID:1577777]
9. Botto, M M, Fong, K Y KY, So, A K AK, Koch, C C and Walport, M J MJ.. (1990) Molecular basis of polymorphisms of human complement component C3.. The Journal of experimental medicine, (1): [PMID:1976733]
10. Poznansky, M C MC, Clissold, P M PM and Lachmann, P J PJ.. (1989) The difference between human C3F and C3S results from a single amino acid change from an asparagine to an aspartate residue at position 1216 on the alpha-chain of the complement component, C3.. Journal of immunology (Baltimore, Md. : 1950), (15): [PMID:2473125]
11. de Bruijn, M H MH and Fey, G H GH.. (1985) Human complement component C3: cDNA coding sequence and derived primary structure.. Proceedings of the National Academy of Sciences of the United States of America, [PMID:2579379]
12. Poznansky, M C MC, Clissold, P M PM and Lachmann, P J PJ.. (1989) The difference between human C3F and C3S results from a single amino acid change from an asparagine to an aspartate residue at position 1216 on the alpha chain of the complement component, C3.. Journal of immunology (Baltimore, Md. : 1950), (1): [PMID:2584723]
13. Klickstein, L B LB and 5 more authors.. (1988) Identification of distinct C3b and C4b recognition sites in the human C3b/C4b receptor (CR1, CD35) by deletion mutagenesis.. The Journal of experimental medicine, (1): [PMID:2972794]
14. Nettesheim, D G DG, Edalji, R P RP, Mollison, K W KW, Greer, J J and Zuiderweg, E R ER.. (1988) Secondary structure of complement component C3a anaphylatoxin in solution as determined by NMR spectroscopy: differences between crystal and solution conformations.. Proceedings of the National Academy of Sciences of the United States of America, [PMID:3260670]
15. Daoudaki, M E ME, Becherer, J D JD and Lambris, J D JD.. (1988) A 34-amino acid peptide of the third component of complement mediates properdin binding.. Journal of immunology (Baltimore, Md. : 1950), (1): [PMID:3279119]
16. Thomas, M L ML, Janatova, J J, Gray, W R WR and Tack, B F BF.. (1982) Third component of human complement: localization of the internal thiolester bond.. Proceedings of the National Academy of Sciences of the United States of America, [PMID:6175959]
17. Oxvig, C C and 7 more authors.. (1995) Identification of angiotensinogen and complement C3dg as novel proteins binding the proform of eosinophil major basic protein in human pregnancy serum and plasma.. The Journal of biological chemistry, (9): [PMID:7539791]
18. Singer, L L and 5 more authors.. (1994) Inherited human complement C3 deficiency. An amino acid substitution in the beta-chain (ASP549 to ASN) impairs C3 secretion.. The Journal of biological chemistry, (11): [PMID:7961791]
19. Dolmer, K K and Sottrup-Jensen, L L.. (1993) Disulfide bridges in human complement component C3b.. FEBS letters, (2): [PMID:8416818]
20. Tao, Y Y, Cianflone, K K, Sniderman, A D AD, Colby-Germinario, S P SP and Germinario, R J RJ.. (1997) Acylation-stimulating protein (ASP) regulates glucose transport in the rat L6 muscle cell line.. Biochimica et biophysica acta, (18): [PMID:9059512]
21. Saleh, J J and 5 more authors.. (1998) Coordinated release of acylation stimulating protein (ASP) and triacylglycerol clearance by human adipose tissue in vivo in the postprandial period.. Journal of lipid research, [PMID:9555951]
22. Nagar, B B, Jones, R G RG, Diefenbach, R J RJ, Isenman, D E DE and Rini, J M JM.. (1998) X-ray crystal structure of C3d: a C3 fragment and ligand for complement receptor 2.. Science (New York, N.Y.), (22): [PMID:9596584]
23. Murray, I I, Köhl, J J and Cianflone, K K.. (1999) Acylation-stimulating protein (ASP): structure-function determinants of cell surface binding and triacylglycerol synthetic activity.. The Biochemical journal, (15): [PMID:10432298]
24. Szakonyi, G G and 5 more authors.. (2001) Structure of complement receptor 2 in complex with its C3d ligand.. Science (New York, N.Y.), (1): [PMID:11387479]
25. Zhang, Hui H, Li, Xiao-Jun XJ, Martin, Daniel B DB and Aebersold, Ruedi R.. (2003) Identification and quantification of N-linked glycoproteins using hydrazide chemistry, stable isotope labeling and mass spectrometry.. Nature biotechnology, [PMID:12754519]
26. Bunkenborg, Jakob J, Pilch, Bartosz J BJ, Podtelejnikov, Alexandre V AV and Wiśniewski, Jacek R JR.. (2004) Screening for N-glycosylated proteins by liquid chromatography mass spectrometry.. Proteomics, [PMID:14760718]
27. Gilbert, Hannah E HE, Eaton, Julian T JT, Hannan, Jonathan P JP, Holers, V Michael VM and Perkins, Stephen J SJ.. (2005) Solution structure of the complex between CR2 SCR 1-2 and C3d of human complement: an X-ray scattering and sedimentation modelling study.. Journal of molecular biology, (25): [PMID:15713468]
28. Janssen, Bert J C BJ and 7 more authors.. (2005) Structures of complement component C3 provide insights into the function and evolution of immunity.. Nature, (22): [PMID:16177781]
29. Lewandrowski, Urs U, Moebius, Jan J, Walter, Ulrich U and Sickmann, Albert A.. (2006) Elucidation of N-glycosylation sites on human platelet proteins: a glycoproteomic approach.. Molecular & cellular proteomics : MCP, [PMID:16263699]
30. Yang, Y Y and 6 more authors.. (2006) Relationships among acylation stimulating protein, adiponectin and complement C3 in lean vs obese type 2 diabetes.. International journal of obesity (2005), [PMID:16302015]
31. Maslowska, Magdalena M, Legakis, Helen H, Assadi, Farzad F and Cianflone, Katherine K.. (2006) Targeting the signaling pathway of acylation stimulating protein.. Journal of lipid research, [PMID:16333141]
32. Wiesmann, Christian C and 10 more authors.. (2006) Structure of C3b in complex with CRIg gives insights into regulation of complement activation.. Nature, (9): [PMID:17051150]
33. Janssen, Bert J C BJ, Christodoulidou, Agni A, McCarthy, Andrew A, Lambris, John D JD and Gros, Piet P.. (2006) Structure of C3b reveals conformational changes that underlie complement activity.. Nature, (9): [PMID:17051160]
34. Yates, John R W JR and 16 more authors.. (2007) Complement C3 variant and the risk of age-related macular degeneration.. The New England journal of medicine, (9): [PMID:17634448]
35. Terao, Yutaka Y and 6 more authors.. (2008) Group A streptococcal cysteine protease degrades C3 (C3b) and contributes to evasion of innate immunity.. The Journal of biological chemistry, (7): [PMID:18160402]
36. Frémeaux-Bacchi, Veronique V and 25 more authors.. (2008) Mutations in complement C3 predispose to development of atypical hemolytic uremic syndrome.. Blood, (15): [PMID:18796626]
37. Wamba, Ponce Cedric Fouejeu PC and 7 more authors.. (2008) Acylation stimulating protein but not complement C3 associates with metabolic syndrome components in Chinese children and adolescents.. European journal of endocrinology, [PMID:18805911]
38. Haupt, Katrin K and 7 more authors.. (2008) The Staphylococcus aureus protein Sbi acts as a complement inhibitor and forms a tripartite complex with host complement Factor H and C3b.. PLoS pathogens, [PMID:19112495]
39. Cui, Wei W, Simaan, May M, Laporte, Stephane S, Lodge, Robert R and Cianflone, Katherine K.. (2009) C5a- and ASP-mediated C5L2 activation, endocytosis and recycling are lost in S323I-C5L2 mutation.. Molecular immunology, [PMID:19615750]
40. Isenman, David E DE, Leung, Elisa E, Mackay, Julia D JD, Bagby, Stefan S and van den Elsen, Jean M H JM.. (2010) Mutational analyses reveal that the staphylococcal immune evasion molecule Sbi and complement receptor 2 (CR2) share overlapping contact residues on C3d: implications for the controversy regarding the CR2/C3d cocrystal structure.. Journal of immunology (Baltimore, Md. : 1950), (15): [PMID:20083651]
41. Maga, Tara K TK, Nishimura, Carla J CJ, Weaver, Amy E AE, Frees, Kathy L KL and Smith, Richard J H RJ.. (2010) Mutations in alternative pathway complement proteins in American patients with atypical hemolytic uremic syndrome.. Human mutation, [PMID:20513133]
42. Shaw, Craig D CD and 6 more authors.. (2010) Delineation of the complement receptor type 2-C3d complex by site-directed mutagenesis and molecular docking.. Journal of molecular biology, (10): [PMID:20951140]
43. Clark, Elizabeth A EA and 7 more authors.. (2011) A structural basis for Staphylococcal complement subversion: X-ray structure of the complement-binding domain of Staphylococcus aureus protein Sbi in complex with ligand C3d.. Molecular immunology, [PMID:21055811]
44. Kajander, Tommi T and 8 more authors.. (2011) Dual interaction of factor H with C3d and glycosaminoglycans in host-nonhost discrimination by complement.. Proceedings of the National Academy of Sciences of the United States of America, (15): [PMID:21285368]
45. Morgan, Hugh P HP and 12 more authors.. (2011) Structural basis for engagement by complement factor H of C3b on a self surface.. Nature structural & molecular biology, [PMID:21317894]
46. van den Elsen, Jean M H JM and Isenman, David E DE.. (2011) A crystal structure of the complex between human complement receptor 2 and its ligand C3d.. Science (New York, N.Y.), (29): [PMID:21527715]
47. Heurich, Meike M and 6 more authors.. (2011) Common polymorphisms in C3, factor B, and factor H collaborate to determine systemic complement activity and disease risk.. Proceedings of the National Academy of Sciences of the United States of America, (24): [PMID:21555552]
48. Seddon, Johanna M JM and 15 more authors.. (2013) Rare variants in CFI, C3 and C9 are associated with high risk of advanced age-related macular degeneration.. Nature genetics, [PMID:24036952]
49. Del Tordello, Elena E, Vacca, Irene I, Ram, Sanjay S, Rappuoli, Rino R and Serruto, Davide D.. (2014) Neisseria meningitidis NalP cleaves human complement C3, facilitating degradation of C3b and survival in human serum.. Proceedings of the National Academy of Sciences of the United States of America, (7): [PMID:24367091]
50. Tagliabracci, Vincent S VS and 14 more authors.. (2015) A Single Kinase Generates the Majority of the Secreted Phosphoproteome.. Cell, (18): [PMID:26091039]
51. Pedersen, Dennis V DV and 11 more authors.. (2017) Functional and structural insight into properdin control of complement alternative pathway amplification.. The EMBO journal, (13): [PMID:28264884]
52. Pedersen, Dennis V and 14 more authors.. (2019) Structural Basis for Properdin Oligomerization and Convertase Stimulation in the Human Complement System.. Frontiers in immunology, [PMID:31507604]

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体积（添加到小瓶中）

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NGM621 (anti-Complement C3)

库存信息

库存信息

库存信息

库存信息

基本信息

产品属性

图片

关联靶点（人）

作用机制

安全和危险性（GHS）

质量标准

质检证书（CoA,COO,BSE/TSE 和分析图谱)

相关产品

参考文献

溶液计算器

摩尔浓度计算器

稀释计算器

复溶计算器