产品名称	Imalumab (anti-MIF), 巨噬细胞迁移抑制因子抑制剂
别名	伊马单抗(抗 MIF)
英文别名	5.3.3.12 \| EC 5.3.2.1 \| GIF \| Glycosylation-inhibiting factor \| L-dopachrome isomerase \| L-dopachrome tautomerase \| MIF \| Phenylpyruvate tautomerase
规格或纯度	无载体, 重组, ExactAb™, 低内毒素, 无叠氮钠, 已验证, 无动物源, ≥95%(SDS-PAGE&SEC-HPLC), 见COA
宿主种属	人(Human)
特异性	MIF
种属反应性	人(Human)
偶联	Unconjugated
作用类型	抑制剂
作用机制	巨噬细胞迁移抑制因子抑制剂

产品属性

克隆类型	重组抗体
Format	Whole IgG
亚型	Human IgG1
轻链亚型	kappa
SDS-PAGE	27.9 kDa (Light Chain) & 51.8 kDa (Heavy Chain), under reducing conditions; 199.5 kDa, under non-reducing conditions.
纯化方法	Protein A purified
纯度	>95%
物理外观	Liquid
储存缓冲液	Supplied as a 0.22μm filtered solution in 100mM Pro-Ac, 20mM Arg, pH5.0.
防腐剂	No
浓度	见COA
储存温度	-80℃储存,避免反复冻融
运输条件	超低温冰袋运输
稳定性与储存	在 -80℃ 下保存 24 个月。收货后建议分装。避免冷冻/解冻循环。
CAS编号和信息	1430205-07-4
分子类型	抗体

图片

ELISA: Imalumab (anti-MIF) (Ab177902)

Imalumab (anti-MIF) (Ab177902) - ELISA
Immobilized Recombinant Human MIF protein (rp148808) at 1.0 μg/mL can bind Imalumab (anti-MIF) (Ab177902) with the EC50 of 108.7 ng/mL.

SEC: Imalumab (anti-MIF) (Ab177902)

Imalumab (anti-MIF) (Ab177902) - SEC
The purity of Imalumab (anti-MIF) (Ab177902) is more than 95% verified by HPLC.

ELISA: Imalumab (anti-MIF) (Ab177902)

Imalumab (anti-MIF) (Ab177902) - ELISA
Immobilized Recombinant Human MIF protein (rp170404) at 1.0 μg/mL can bind Imalumab (anti-MIF) (Ab177902) with the EC₅₀ of 110.0 ng/mL.

关联靶点（人）

MIF Tchem 巨噬细胞移动抑制因子(Macrophage migration inhibitory factor) (0 活性数据)

点击查看靶蛋白信息： MIF

活性类型	活性值-log(M)	作用机制	期刊	参考文献(PubMed IDs)

MIF Tchem Macrophage migration inhibitory factor (979 活性数据)

点击查看靶蛋白信息： MIF

活性类型	Relation	Activity value	Units	Action Type	期刊	PubMed Id	doi	Assay Aladdin ID

作用机制

作用机制	Action Type	target ID	Target Name	Target Type	Target Organism	Binding Site Name	参考文献

安全和危险性（GHS）

SDS英文版

质量标准

质量标准

质检证书（CoA,COO,BSE/TSE 和分析图谱)

C of A & Other Certificates(BSE/TSE, COO):

输入批号以搜索分析图谱:

通过匹配包装上的批号来查找并下载产品的 COA，每批产品都进行了严格的验证，您可放心使用！

找到6个结果

批号(Lot Number)	证书类型	日期	货号
ZJ24F1114593	分析证书	24-11-29	Ab177902
ZJ24F1114592	分析证书	24-11-29	Ab177902
ZJ24F1114591	分析证书	24-11-29	Ab177902
ZJ24F0707793	分析证书	24-07-04	Ab177902
ZJ24F0707792	分析证书	24-07-04	Ab177902
ZJ24F0707791	分析证书	24-07-04	Ab177902

参考文献

1. Leng L, Metz CN, Fang Y, Xu J, Donnelly S, Baugh J, Delohery T, Chen Y, Mitchell RA, Bucala R. (2003) MIF signal transduction initiated by binding to CD74.. J Exp Med, 197 (11): (1467-76). [PMID:12782713]
2. Trivedi-Parmar V, Jorgensen WL. (2018) Advances and Insights for Small Molecule Inhibition of Macrophage Migration Inhibitory Factor.. J Med Chem, 61 (18): (8104-8119). [PMID:29812929]
3. Lubetsky JB, Swope M, Dealwis C, Blake P, Lolis E. (1999) Pro-1 of macrophage migration inhibitory factor functions as a catalytic base in the phenylpyruvate tautomerase activity.. Biochemistry, 38 (22): (7346-54). [PMID:10353846]
4. Orita M, Yamamoto S, Katayama N, Aoki M, Takayama K, Yamagiwa Y, Seki N, Suzuki H, Kurihara H, Sakashita H et al.. (2001) Coumarin and chromen-4-one analogues as tautomerase inhibitors of macrophage migration inhibitory factor: discovery and X-ray crystallography.. J Med Chem, 44 (4): (540-7). [PMID:11170644]
5. Ouertatani-Sakouhi H, El-Turk F, Fauvet B, Cho MK, Pinar Karpinar D, Le Roy D, Dewor M, Roger T, Bernhagen J, Calandra T, Zweckstetter M, Lashuel HA. Identification and characterization of novel classes of macrophage migration inhibitory factor (MIF) inhibitors with distinct mechanisms of action.. J Biol Chem, [PMID:20516071]
6. Gregg V Crichlow,Jodi B Lubetsky,Lin Leng,Richard Bucala,Elias J Lolis. (2008-12-19) Structural and kinetic analyses of macrophage migration inhibitory factor active site interactions.. Biochemistry, 48 ((1)): (132-139). [PMID:19090677]
7. Alissa A Hare,Lin Leng,Sunilkumar Gandavadi,Xin Du,Zoe Cournia,Richard Bucala,William L Jorgensen. (2010-08-24) Optimization of N-benzyl-benzoxazol-2-ones as receptor antagonists of macrophage migration inhibitory factor (MIF).. Bioorganic & medicinal chemistry letters, 20 ((19)): (5811-5814). [PMID:20728358]
8. William L Jorgensen,Alexander Trofimov,Xin Du,Alissa A Hare,Lin Leng,Richard Bucala. (2011-07-02) Benzisothiazolones as modulators of macrophage migration inhibitory factor.. Bioorganic & medicinal chemistry letters, 21 ((15)): (4545-4549). [PMID:21719283]
9. Crichlow GV, Cheng KF, Dabideen D, Ochani M, Aljabari B, Pavlov VA, Miller EJ, Lolis E, Al-Abed Y.. (2007) Alternative chemical modifications reverse the binding orientation of a pharmacophore scaffold in the active site of macrophage migration inhibitory factor.. J Biol Chem, 282 (32): (23089-23095). [PMID:17526494] [10.1074/jbc.m701825200]
10. Cournia Z, Leng L, Gandavadi S, Du X, Bucala R, Jorgensen WL.. (2009) Discovery of human macrophage migration inhibitory factor (MIF)-CD74 antagonists via virtual screening.. J Med Chem, 52 (2): (416-424). [PMID:19090668] [10.1021/jm801100v]
11. El Turk F, Fauvet B, Ouertatani-Sakouhi H, Lugari A, Betzi S, Roche P, Morelli X, Lashuel HA.. (2010) An integrative in silico methodology for the identification of modulators of macrophage migration inhibitory factor (MIF) tautomerase activity.. Bioorg Med Chem, 18 (14): (5425-5440). [PMID:20639113] [10.1016/j.bmc.2010.05.010]
12. Jorgensen WL, Gandavadi S, Du X, Hare AA, Trofimov A, Leng L, Bucala R.. (2010) Receptor agonists of macrophage migration inhibitory factor.. Bioorg Med Chem Lett, 20 (23): (7033-7036). [PMID:20971005] [10.1016/j.bmcl.2010.09.118]
13. Alam A, Pal C, Goyal M, Kundu MK, Kumar R, Iqbal MS, Dey S, Bindu S, Sarkar S, Pal U, Maiti NC, Adhikari S, Bandyopadhyay U.. (2011) Synthesis and bio-evaluation of human macrophage migration inhibitory factor inhibitor to develop anti-inflammatory agent.. Bioorg Med Chem, 19 (24): (7365-7373). [PMID:22088307] [10.1016/j.bmc.2011.10.056]
14. Dahlgren MK, Garcia AB, Hare AA, Tirado-Rives J, Leng L, Bucala R, Jorgensen WL.. (2012) Virtual screening and optimization yield low-nanomolar inhibitors of the tautomerase activity of Plasmodium falciparum macrophage migration inhibitory factor.. J Med Chem, 55 (22): (10148-10159). [PMID:23067344] [10.1021/jm301269s]
15. Yu WL, Jones BD, Kang M, Hammons JC, La Clair JJ, Burkart MD.. (2013) Spirohexenolide A targets human macrophage migration inhibitory factor (hMIF).. J Nat Prod, 76 (5): (817-823). [PMID:23659282] [10.1021/np3004497]
16. Pantouris G, Rajasekaran D, Garcia AB, Ruiz VG, Leng L, Jorgensen WL, Bucala R, Lolis EJ.. (2014) Crystallographic and receptor binding characterization of Plasmodium falciparum macrophage migration inhibitory factor complexed to two potent inhibitors.. J Med Chem, 57 (20): (8652-8656). [PMID:25268646] [10.1021/jm501168q]
17. Spencer ES, Dale EJ, Gommans AL, Rutledge MT, Vo CT, Nakatani Y, Gamble AB, Smith RA, Wilbanks SM, Hampton MB, Tyndall JD.. (2015) Multiple binding modes of isothiocyanates that inhibit macrophage migration inhibitory factor.. Eur J Med Chem, 93 (501-510). [PMID:25743213] [10.1016/j.ejmech.2015.02.012]
18. Le Hiress M, Akagah B, Bernadat G, Tu L, Thuillet R, Huertas A, Phan C, Fadel E, Simonneau G, Humbert M, Jalce G, Guignabert C.. (2018) Design, Synthesis, and Biological Activity of New N-(Phenylmethyl)-benzoxazol-2-thiones as Macrophage Migration Inhibitory Factor (MIF) Antagonists: Efficacies in Experimental Pulmonary Hypertension.. J Med Chem, 61 (7): (2725-2736). [PMID:29526099] [10.1021/acs.jmedchem.7b01312]
19. Kok T, Wapenaar H, Wang K, Neochoritis CG, Zarganes-Tzitzikas T, Proietti G, Eleftheriadis N, Kurpiewska K, Kalinowska-Tłuścik J, Cool RH, Poelarends GJ, Dömling A, Dekker FJ.. (2018) Discovery of chromenes as inhibitors of macrophage migration inhibitory factor.. Bioorg Med Chem, 26 (5): (999-1005). [PMID:29428527] [10.1016/j.bmc.2017.12.032]
20. Cirillo PF,Asojo OA,Khire U,Lee Y,Mootien S,Hegan P,Sutherland AG,Peterson-Roth E,Ledizet M,Koski RA,Anthony KG. (2020) Inhibition of Macrophage Migration Inhibitory Factor by a Chimera of Two Allosteric Binders.. ACS Med Chem Lett, 11 (10.0): (1843-1847). [PMID:33062162] [10.1021/acsmedchemlett.9b00351]
21. Xiao Z,Fokkens M,Chen D,Kok T,Proietti G,van Merkerk R,Poelarends GJ,Dekker FJ. (2020) Structure-activity relationships for binding of 4-substituted triazole-phenols to macrophage migration inhibitory factor (MIF).. Eur J Med Chem, 186 (111849-111849). [PMID:31767137] [10.1016/j.ejmech.2019.111849]
22. Hochstrasser, D F DF and 9 more authors.. (1992) Human liver protein map: a reference database established by microsequencing and gel comparison.. Electrophoresis, [PMID:1286669]
23. Weiser, W Y WY and 5 more authors.. (1989) Molecular cloning of a cDNA encoding a human macrophage migration inhibitory factor.. Proceedings of the National Academy of Sciences of the United States of America, [PMID:2552447]
24. Wistow, G J GJ, Shaughnessy, M P MP, Lee, D C DC, Hodin, J J and Zelenka, P S PS.. (1993) A macrophage migration inhibitory factor is expressed in the differentiating cells of the eye lens.. Proceedings of the National Academy of Sciences of the United States of America, (15): [PMID:7679497]
25. Zeng, F Y FY and 5 more authors.. (1993) The major binding protein of the interferon antagonist sarcolectin in human placenta is a macrophage migration inhibitory factor.. Archives of biochemistry and biophysics, (15): [PMID:7683862]
26. Bernhagen, J J and 5 more authors.. (1994) Purification, bioactivity, and secondary structure analysis of mouse and human macrophage migration inhibitory factor (MIF).. Biochemistry, (29): [PMID:7947826]
27. Paralkar, V V and Wistow, G G.. (1994) Cloning the human gene for macrophage migration inhibitory factor (MIF).. Genomics, (1): [PMID:8188240]
28. Mikayama, T T and 9 more authors.. (1993) Molecular cloning and functional expression of a cDNA encoding glycosylation-inhibiting factor.. Proceedings of the National Academy of Sciences of the United States of America, (1): [PMID:8234256]
29. Kato, Y Y and 7 more authors.. (1996) The crystal structure of human glycosylation-inhibiting factor is a trimeric barrel with three 6-stranded beta-sheets.. Proceedings of the National Academy of Sciences of the United States of America, (2): [PMID:8610159]
30. Sun, H W HW, Bernhagen, J J, Bucala, R R and Lolis, E E.. (1996) Crystal structure at 2.6-A resolution of human macrophage migration inhibitory factor.. Proceedings of the National Academy of Sciences of the United States of America, (28): [PMID:8643551]
31. Sugimoto, H H, Suzuki, M M, Nakagawa, A A, Tanaka, I I and Nishihira, J J.. (1996) Crystal structure of macrophage migration inhibitory factor from human lymphocyte at 2.1 A resolution.. FEBS letters, (1): [PMID:8766818]
32. Kleemann, R R and 13 more authors.. (2000) Intracellular action of the cytokine MIF to modulate AP-1 activity and the cell cycle through Jab1.. Nature, (9): [PMID:11089976]
33. (2001) A novel 5'-flanking region polymorphism of macrophage migration inhibitory factor is associated with systemic-onset juvenile idiopathic arthritis.. Arthritis and rheumatism, [PMID:11508429]
34. Gevaert, Kris K and 6 more authors.. (2003) Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides.. Nature biotechnology, [PMID:12665801]
35. Shen, Li L and 7 more authors.. (2003) The apoptosis-associated protein BNIPL interacts with two cell proliferation-related proteins, MIF and GFER.. FEBS letters, (10): [PMID:12681488]
36. Emonts, Marieke M and 10 more authors.. (2007) Association between high levels of blood macrophage migration inhibitory factor, inappropriate adrenal response, and early death in patients with severe sepsis.. Clinical infectious diseases : an official publication of the Infectious Diseases Society of America, (15): [PMID:17443469]
37. Merk, Melanie M and 13 more authors.. (2009) The Golgi-associated protein p115 mediates the secretion of macrophage migration inhibitory factor.. Journal of immunology (Baltimore, Md. : 1950), (1): [PMID:19454686]
38. Alam, Athar A and 12 more authors.. (2012) Novel anti-inflammatory activity of epoxyazadiradione against macrophage migration inhibitory factor: inhibition of tautomerase and proinflammatory activities of macrophage migration inhibitory factor.. The Journal of biological chemistry, (13): [PMID:22645149]
39. Fan, Chengpeng C and 7 more authors.. (2013) MIF intersubunit disulfide mutant antagonist supports activation of CD74 by endogenous MIF trimer at physiologic concentrations.. Proceedings of the National Academy of Sciences of the United States of America, (2): [PMID:23776208]

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Imalumab (anti-MIF), 巨噬细胞迁移抑制因子抑制剂

库存信息

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基本信息

产品属性

图片

关联靶点（人）

作用机制

安全和危险性（GHS）

质量标准

质检证书（CoA,COO,BSE/TSE 和分析图谱)

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参考文献

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