AMG 108 (anti-IL-1R1)

    应用:
  • Animal Model
  • ELISA
  • Flow Cytometry
  • Functional Assay
功能和特点
  • 宿主种属: 人(Human)
  • 种属反应性: 人(Human)
  • 亚型: Human IgG2
  • 偶联: Unconjugated
有货

库存信息

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库存信息

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库存信息

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库存信息

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货号 (SKU) 包装规格 是否现货 价格 数量
Ab177865-100μg
100μg 现货 Stock Image
Ab177865-1mg
1mg 现货 Stock Image
Ab177865-5mg
5mg 现货 Stock Image
Ab177865-10mg
10mg 期货 Stock Image

基本信息

产品名称 AMG 108 (anti-IL-1R1)
别名 AMG 108(抗 IL-1R1)
英文别名 CD121 antigen-like family member A | EC 3.2.2.6 | IL-1R-1 | IL-1R-alpha | IL-1RT1 | IL-1RT-1 | Interleukin-1 receptor alpha | Interleukin-1 receptor type I | p80
规格或纯度 无载体, 重组, ExactAb™, 低内毒素, 无叠氮钠, 已验证, 无动物源, ≥95%(SDS-PAGE&SEC-HPLC), 见COA
宿主种属 人(Human)
特异性 IL1R1
种属反应性 人(Human)
偶联 Unconjugated

产品属性

克隆类型 重组抗体
Format Whole IgG
亚型 Human IgG2
轻链亚型 kappa
SDS-PAGE 145.5 kDa
纯化方法 Protein A purified
纯度 >95%
物理外观 Liquid
储存缓冲液 Supplied as a 0.22μm filtered solution in 100mM Pro-Ac, 20mM Arg, pH 5.0
防腐剂 No
浓度 见COA
储存温度 -80℃储存,避免反复冻融
运输条件 超低温冰袋运输
稳定性与储存 在 -80℃ 下保存 24 个月。收货后建议分装。避免冷冻/解冻循环。
分子类型 抗体

图片

AMG 108 (anti-IL-1R1) (Ab177865) - Flow Cytometry
Flow Cytometry analysis of HeLa cells labelling IL-1R1 (red) with AMG 108 (anti-IL-1R1) (Ab177865). Goat Anti-Human IgG (PE) (Ab175838) at a dilution of 1/1000 was used as the secondary antibody. Blue - Isotype control, human IgG (Ab170213). Black - Unlabelled control, cells without incubation with primary antibody.

AMG 108 (anti-IL-1R1) (Ab177865) - SEC
The purity of AMG 108 (anti-IL-1R1) (Ab177865) is more than 95% verified by HPLC.

关联靶点(人)

IL1R1 Tclin 白细胞介素-1 受体 1 型(Interleukin-1 receptor type 1) (0 活性数据)
活性类型 活性值-log(M) 作用机制 期刊 参考文献(PubMed IDs)

作用机制

作用机制 Action Type target ID Target Name Target Type Target Organism Binding Site Name 参考文献

安全和危险性(GHS)

质量标准

质检证书(CoA,COO,BSE/TSE 和分析图谱)

C of A & Other Certificates(BSE/TSE, COO):
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找到3个结果

批号(Lot Number) 证书类型 日期 货号
ZJ24F1013245 分析证书 24-11-01 Ab177865
ZJ24F1013244 分析证书 24-11-01 Ab177865
ZJ24F1013243 分析证书 24-11-01 Ab177865

参考文献

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3. Haile PA, Votta BJ, Marquis RW, Bury MJ, Mehlmann JF, Singhaus Jr R, Charnley AK, Lakdawala AS, Convery MA, Lipshutz DB et al..  (2016)  The Identification and Pharmacological Characterization of 6-(tert-Butylsulfonyl)-N-(5-fluoro-1H-indazol-3-yl)quinolin-4-amine (GSK583), a Highly Potent and Selective Inhibitor of RIP2 Kinase..  J Med Chem,  59  (10): (4867-80).  [PMID:27109867]
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9. Sims, J E JE and 6 more authors..  (1989)  Cloning the interleukin 1 receptor from human T cells..  Proceedings of the National Academy of Sciences of the United States of America,  [PMID:2530587]
10. Chua, A O AO and Gubler, U U..  (1989)  Sequence of the cDNA for the human fibroblast type interleukin-1 receptor..  Nucleic acids research,  (11): [PMID:2532321]
11. Vigers, G P GP, Anderson, L J LJ, Caffes, P P and Brandhuber, B J BJ..  (1997)  Crystal structure of the type-I interleukin-1 receptor complexed with interleukin-1beta..  Nature,  (13): [PMID:9062193]
12. Huang, J J, Gao, X X, Li, S S and Cao, Z Z..  (1997)  Recruitment of IRAK to the interleukin 1 receptor complex requires interleukin 1 receptor accessory protein..  Proceedings of the National Academy of Sciences of the United States of America,  (25): [PMID:9371760]
13. Vannier, E E and 6 more authors..  (1999)  Elevated circulating levels of soluble interleukin-1 receptor type II during interleukin-2 immunotherapy..  European cytokine network,  [PMID:10210771]
14. Tominaga, K K and 7 more authors..  (2000)  IL-12 synergizes with IL-18 or IL-1beta for IFN-gamma production from human T cells..  International immunology,  [PMID:10653850]
15. Vigers, G P GP, Dripps, D J DJ, Edwards, C K CK and Brandhuber, B J BJ..  (2000)  X-ray crystal structure of a small antagonist peptide bound to interleukin-1 receptor type 1..  The Journal of biological chemistry,  (24): [PMID:10903327]
16. Vamvakopoulos, Joannis J, Green, Colin C and Metcalfe, Su S..  (2002)  Genetic control of IL-1beta bioactivity through differential regulation of the IL-1 receptor antagonist..  European journal of immunology,  [PMID:12355453]
17. and Dayer, J M JM..  (2003)  The pivotal role of interleukin-1 in the clinical manifestations of rheumatoid arthritis..  Rheumatology (Oxford, England),  [PMID:12817089]
18. Do, Herve H and 12 more authors..  (2006)  Exhaustive genotyping of the interleukin-1 family genes and associations with AIDS progression in a French cohort..  The Journal of infectious diseases,  (1): [PMID:17083033]
19. So, Alexander A, De Smedt, Thibaut T, Revaz, Sylvie S and Tschopp, Jürg J..  (2007)  A pilot study of IL-1 inhibition by anakinra in acute gout..  Arthritis research & therapy,  [PMID:17352828]
20. Tang, Ying-hong YH, Zhang, Shu-ping SP, Liang, Yan Y and Deng, Chang-qing CQ..  (2007)  [Effects of Panax notoginseng saponins on mRNA expressions of interleukin-1 beta, its correlative factors and cysteinyl-aspartate specific protease after cerebral ischemia-reperfusion in rats]..  Zhong xi yi jie he xue bao = Journal of Chinese integrative medicine,  [PMID:17498496]

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