Galiximab (anti-CD80), T 淋巴细胞活化抗原 CD80 抑制剂

    应用:
  • Animal Model
  • ELISA
  • Flow Cytometry
  • Functional Assay
功能和特点
  • 宿主种属: 人(Human)
  • 种属反应性: 人(Human), 食蟹猴(Cynomolgus monkey)
  • 亚型: Human IgG1
  • 偶联: Unconjugated
有货

库存信息

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库存信息

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库存信息

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库存信息

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货号 (SKU) 包装规格 是否现货 价格 数量
Ab177850-100μg
100μg 现货 Stock Image
Ab177850-1mg
1mg 现货 Stock Image
Ab177850-5mg
5mg 现货 Stock Image
Ab177850-10mg
10mg 期货 Stock Image

基本信息

产品名称 Galiximab (anti-CD80), T 淋巴细胞活化抗原 CD80 抑制剂
别名 加利昔单抗(抗 CD80)
英文别名 Activation B7-1 antigen | B7 | BB1 | CTLA-4 counter-receptor B7.1
规格或纯度 无载体, 重组, ExactAb™, 低内毒素, 无叠氮钠, 已验证, 无动物源, ≥95%(SDS-PAGE&SEC-HPLC), 见COA
宿主种属 人(Human)
特异性 CD80
种属反应性 人(Human),食蟹猴(Cynomolgus monkey)
偶联 Unconjugated
作用类型 抑制剂
作用机制 T 淋巴细胞活化抗原 CD80 抑制剂

产品属性

克隆类型 重组抗体
Format Whole IgG
亚型 Human IgG1
轻链亚型 lambda
SDS-PAGE 28.8 kDa (Light Chain) & 51.6 kDa (Heavy Chain), under reducing conditions; 183.4 kDa, under non-reducing conditions.
纯化方法 Protein A purified
纯度 >95%
物理外观 Liquid
储存缓冲液 Supplied as a 0.22μm filtered solution in 100mM Pro-Ac, 20mM Arg, pH 5.0
防腐剂 No
浓度 见COA
储存温度 -80℃储存,避免反复冻融
运输条件 超低温冰袋运输
稳定性与储存 在 -80℃ 下保存 24 个月。收货后建议分装。避免冷冻/解冻循环。
CAS编号和信息 357613-77-5
分子类型 抗体

图片

Galiximab (anti-CD80) (Ab177850) - Flow Cytometry
Flow Cytometry analysis of Raji cells labelling CD80 (red) with Galiximab (anti-CD80) (Ab177850). Goat Anti-Human IgG (PE) (Ab175838) at a dilution of 1/1000 was used as the secondary antibody. Blue - Isotype control, human IgG (Ab170213). Black - Unlabelled control, cells without incubation with primary antibody.

Galiximab (anti-CD80) (Ab177850) - SEC
The purity of Galiximab (anti-CD80) (Ab177850) is more than 95% verified by HPLC.

Galiximab (anti-CD80) (Ab177850) - ELISA
Immobilized Recombinant Human CD80 Protein (rp189426) at 1.0 μg/mL can bind Galiximab (anti-CD80) (Ab177850) with the EC50 of 95.6 ng/mL.

关联靶点(人)

CD80 Tclin T淋巴细胞活化抗原CD80(T-lymphocyte activation antigen CD80) (0 活性数据)
活性类型 活性值-log(M) 作用机制 期刊 参考文献(PubMed IDs)

作用机制

作用机制 Action Type target ID Target Name Target Type Target Organism Binding Site Name 参考文献

安全和危险性(GHS)

质量标准

质检证书(CoA,COO,BSE/TSE 和分析图谱)

C of A & Other Certificates(BSE/TSE, COO):
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找到5个结果

批号(Lot Number) 证书类型 日期 货号
ZJ24F1013070 分析证书 24-10-30 Ab177850
ZJ24F1013071 分析证书 24-10-30 Ab177850
ZJ24F1013072 分析证书 24-10-30 Ab177850
ZJ23F1202072 分析证书 23-12-20 Ab177850
ZJ23F1202073 分析证书 23-12-20 Ab177850

参考文献

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18. Vincenti, Flavio F and Luggen, Michael M..  (2007)  T cell costimulation: a rational target in the therapeutic armamentarium for autoimmune diseases and transplantation..  Annual review of medicine,  [PMID:17020493]
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20. Leonard, J P JP and 14 more authors..  (2007)  A phase I/II study of galiximab (an anti-CD80 monoclonal antibody) in combination with rituximab for relapsed or refractory, follicular lymphoma..  Annals of oncology : official journal of the European Society for Medical Oncology,  [PMID:17470451]
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