TTX-030 (anti-ENTPD1)

    应用:
  • Animal Model
  • ELISA
  • Flow Cytometry
  • Functional Assay
功能和特点
  • 宿主种属: 人(Human)
  • 种属反应性: 人(Human)
  • 亚型: Human IgG4SP
  • 偶联: Unconjugated
有货

库存信息

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库存信息

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库存信息

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库存信息

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货号 (SKU) 包装规格 是否现货 价格 数量
Ab176608-100μg
100μg 现货 Stock Image
Ab176608-1mg
1mg 现货 Stock Image
Ab176608-5mg
5mg 现货 Stock Image
Ab176608-10mg
10mg 期货 Stock Image

基本信息

产品名称 TTX-030 (anti-ENTPD1)
英文别名 EC 3.6.1.5 | Ecto-apyrase | Ecto-ATP diphosphohydrolase 1 | Ecto-ATPase 1 | Ecto-ATPDase 1 | Lymphoid cell activation antigen | NTPDase 1
规格或纯度 无载体, 重组, ExactAb™, 低内毒素, 无叠氮钠, 已验证, 无动物源, ≥95%(SDS-PAGE&SEC-HPLC), 见COA
宿主种属 人(Human)
特异性 ENTPD1
种属反应性 人(Human)
偶联 Unconjugated

产品属性

克隆类型 重组抗体
Format Whole IgG
亚型 Human IgG4SP
轻链亚型 kappa
SDS-PAGE 150 kDa
纯化方法 Protein A purified
纯度 >95%
物理外观 Liquid
储存缓冲液 Supplied as a 0.22μm filtered solution in 100mM Pro-Ac, 20mM Arg, pH 5.0
防腐剂 No
浓度 见COA
储存温度 -80℃储存,避免反复冻融
运输条件 超低温冰袋运输
稳定性与储存 在 -80℃ 下保存 24 个月。收货后建议分装。避免冷冻/解冻循环。
分子类型 抗体

图片

TTX-030 (anti-ENTPD1) (Ab176608) - Flow Cytometry
Flow Cytometry analysis of human peripheral blood lymphocytes labelling ENTPD1 with TTX-030 (anti-ENTPD1) (Ab176608) conjugated with biotin (right panel) compared with Human IgG (Ab170213) conjugated with biotin - Isotype Control (left panel) and detected with SA-PE (rp156150).

TTX-030 (anti-ENTPD1) (Ab176608) - Flow Cytometry
Flow Cytometry analysis of human peripheral blood lymphocytes labelling ENTPD1 (red) with TTX-030 (anti-ENTPD1) (Ab176608) conjugated with biotin and detected with SA-PE (rp156150). Blue - Isotype control, human IgG (Ab170213) conjugated with biotin. Black - Unlabelled control, cells without incubation with primary antibody.

TTX-030 (anti-ENTPD1) (Ab176608) - SEC
The purity of TTX-030 (anti-ENTPD1) (Ab176608) is more than 95% verified by HPLC.

TTX-030 (anti-ENTPD1) (Ab176608) - ELISA
Immobilized huCD39ECD-chis at 2.0 μg/mL can bind TTX-030 (anti-ENTPD1) (Ab176608) with the EC₅₀ of 6.56 ng/mL.

关联靶点(人)

ENTPD1 Tchem 外核苷三磷酸二磷酸水解酶1(Ectonucleoside triphosphate diphosphohydrolase 1) (0 活性数据)
活性类型 活性值-log(M) 作用机制 期刊 参考文献(PubMed IDs)

作用机制

作用机制 Action Type target ID Target Name Target Type Target Organism Binding Site Name 参考文献

安全和危险性(GHS)

质量标准

质检证书(CoA,COO,BSE/TSE 和分析图谱)

C of A & Other Certificates(BSE/TSE, COO):
输入批号以搜索分析图谱:

通过匹配包装上的批号来查找并下载产品的 COA,每批产品都进行了严格的验证,您可放心使用!

找到6个结果

批号(Lot Number) 证书类型 日期 货号
ZJ24F1114550 分析证书 24-11-28 Ab176608
ZJ24F1114549 分析证书 24-11-28 Ab176608
ZJ24F1114548 分析证书 24-11-28 Ab176608
ZJ24F0404217 分析证书 24-04-08 Ab176608
ZJ24F0404216 分析证书 24-04-08 Ab176608
ZJ24F0404215 分析证书 24-04-08 Ab176608

参考文献

1. Azran S, Förster D, Danino O, Nadel Y, Reiser G, Fischer B.  (2013)  Highly efficient biocompatible neuroprotectants with dual activity as antioxidants and P2Y receptor agonists..  J Med Chem,  56  (12): (4938-52).  [PMID:23751098]
2. Brunschweiger A, Iqbal J, Umbach F, Scheiff AB, Munkonda MN, Sévigny J, Knowles AF, Müller CE.  (2008)  Selective nucleoside triphosphate diphosphohydrolase-2 (NTPDase2) inhibitors: nucleotide mimetics derived from uridine-5'-carboxamide..  J Med Chem,  51  (15): (4518-28).  [PMID:18630897]
3. Eliahu SE, Camden J, Lecka J, Weisman GA, Sévigny J, Gélinas S, Fischer B..  (2009)  Identification of hydrolytically stable and selective P2Y(1) receptor agonists..  Eur J Med Chem,  44  (4): (1525-1536).  [PMID:18760862] [10.1016/j.ejmech.2008.07.015]
4. Eliahu S, Lecka J, Reiser G, Haas M, Bigonnesse F, Lévesque SA, Pelletier J, Sévigny J, Fischer B..  (2010)  Diadenosine 5',5''-(boranated)polyphosphonate analogues as selective nucleotide pyrophosphatase/phosphodiesterase inhibitors..  J Med Chem,  53  (24): (8485-8497).  [PMID:21090681] [10.1021/jm100597c]
5. Nadel Y, Lecka J, Gilad Y, Ben-David G, Förster D, Reiser G, Kenigsberg S, Camden J, Weisman GA, Senderowitz H, Sévigny J, Fischer B..  (2014)  Highly potent and selective ectonucleotide pyrophosphatase/phosphodiesterase I inhibitors based on an adenosine 5'-(α or γ)-thio-(α,β- or β,γ)-methylenetriphosphate scaffold..  J Med Chem,  57  (11): (4677-4691).  [PMID:24846781] [10.1021/jm500196c]
6. Gillerman I, Lecka J, Simhaev L, Munkonda MN, Fausther M, Martín-Satué M, Senderowitz H, Sévigny J, Fischer B..  (2014)  2-Hexylthio-β,γ-CH2-ATP is an effective and selective NTPDase2 inhibitor..  J Med Chem,  57  (14): (5919-5934).  [PMID:24972256] [10.1021/jm401933c]
7. Lee SY, Perotti A, De Jonghe S, Herdewijn P, Hanck T, Müller CE..  (2016)  Thiazolo[3,2-a]benzimidazol-3(2H)-one derivatives: Structure-activity relationships of selective nucleotide pyrophosphatase/phosphodiesterase1 (NPP1) inhibitors..  Bioorg Med Chem,  24  (14): (3157-3165).  [PMID:27265686] [10.1016/j.bmc.2016.05.046]
8. Fiene A, Baqi Y, Malik EM, Newton P, Li W, Lee SY, Hartland EL, Müller CE..  (2016)  Inhibitors for the bacterial ectonucleotidase Lp1NTPDase from Legionella pneumophila..  Bioorg Med Chem,  24  (18): (4363-4371).  [PMID:27522579] [10.1016/j.bmc.2016.07.027]
9. Zelikman V, Pelletier J, Simhaev L, Sela A, Gendron FP, Arguin G, Senderowitz H, Sévigny J, Fischer B..  (2018)  Highly Selective and Potent Ectonucleotide Pyrophosphatase-1 (NPP1) Inhibitors Based on Uridine 5'-Pα,α-Dithiophosphate Analogues..  J Med Chem,  61  (9): (3939-3951).  [PMID:29681152] [10.1021/acs.jmedchem.7b01906]
10. Nassir M, Pelletier J, Arad U, Arguin G, Khazanov N, Gendron FP, Sévigny J, Senderowitz H, Fischer B..  (2019)  Structure-activity relationship study of NPP1 inhibitors based on uracil-N1-(methoxy)ethyl-β-phosphate scaffold..  Eur J Med Chem,  184  (111754-111754).  [PMID:31610377] [10.1016/j.ejmech.2019.111754]
11. Maliszewski, C R CR and 9 more authors..  (1994)  The CD39 lymphoid cell activation antigen. Molecular cloning and structural characterization..  Journal of immunology (Baltimore, Md. : 1950),  (15): [PMID:7930580]
12. Christoforidis, S S, Papamarcaki, T T, Galaris, D D, Kellner, R R and Tsolas, O O..  (1995)  Purification and properties of human placental ATP diphosphohydrolase..  European journal of biochemistry,  (15): [PMID:8529670]
13. Wang, T F TF and Guidotti, G G..  (1996)  CD39 is an ecto-(Ca2+,Mg2+)-apyrase..  The Journal of biological chemistry,  (26): [PMID:8626624]
14. Kaczmarek, E E and 7 more authors..  (1996)  Identification and characterization of CD39/vascular ATP diphosphohydrolase..  The Journal of biological chemistry,  (20): [PMID:8955160]
15. Robson, S C SC and 7 more authors..  (1997)  Loss of ATP diphosphohydrolase activity with endothelial cell activation..  The Journal of experimental medicine,  (6): [PMID:8996251]
16. Makita, K K and 11 more authors..  (1998)  Placental ecto-ATP diphosphohydrolase: its structural feature distinct from CD39, localization and inhibition on shear-induced platelet aggregation..  International journal of hematology,  [PMID:9846014]
17. Matsumoto, M M and 8 more authors..  (1999)  The cDNA cloning of human placental ecto-ATP diphosphohydrolases I and II..  FEBS letters,  (25): [PMID:10405171]
18. Koziak, K K and 10 more authors..  (2000)  Palmitoylation targets CD39/endothelial ATP diphosphohydrolase to caveolae..  The Journal of biological chemistry,  (21): [PMID:10636909]
19. Deloukas, P P and 135 more authors..  (2004)  The DNA sequence and comparative analysis of human chromosome 10..  Nature,  (27): [PMID:15164054]
20. Novarino, Gaia G and 51 more authors..  (2014)  Exome sequencing links corticospinal motor neuron disease to common neurodegenerative disorders..  Science (New York, N.Y.),  (31): [PMID:24482476]

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