| 货号 (SKU) | 包装规格 | 是否现货 | 价格 | 数量 |
|---|---|---|---|---|
| Ab176598-100μg |
100μg |
现货  |
| |
| Ab176598-1mg |
1mg |
现货 |
| |
| Ab176598-5mg |
5mg |
现货 |
| |
| Ab176598-10mg |
10mg |
期货 |
|
| 产品名称 | Navicixizumab (anti-DLL4) |
|---|---|
| 别名 | 那赛昔珠单抗 | 纳维珠单抗（抗 DLL4） |
| 英文别名 | AOS6 antibody | Delta 4 antibody | delta 4 precursor antibody | Delta ligand 4 antibody | delta ligand 4 precursor antibody | Delta like 4 antibody | Delta like 4 homolog antibody | Delta like 4 protein antibody | Delta like canonical Notch ligand 4 antib |
| 规格或纯度 | 无载体, 重组, ExactAb™, 低内毒素, 无叠氮钠, 已验证, 无动物源, ≥95%(SDS-PAGE&SEC-HPLC), 见COA |
| 宿主种属 | 人(Human) |
| 特异性 | DLL4 |
| 种属反应性 | 人(Human),食蟹猴(Cynomolgus monkey) |
| 偶联 | Unconjugated |
| 克隆类型 | 重组抗体 |
|---|---|
| Format | Whole IgG |
| 亚型 | Human IgG2SA |
| 轻链亚型 | kappa |
| SDS-PAGE | 146.17 kDa |
| 纯化方法 | Protein A purified |
| 纯度 | >95% |
| 物理外观 | Liquid |
| 储存缓冲液 | Supplied as a 0.22μm filtered solution in 100mM Pro-Ac, 20mM Arg, pH 5.0 |
| 防腐剂 | No |
| 浓度 | 见COA |
| 储存温度 | -80℃储存,避免反复冻融 |
| 运输条件 | 超低温冰袋运输 |
| 稳定性与储存 | 在 -80℃ 下保存 24 个月。收货后建议分装。避免冷冻/解冻循环。 |
| CAS编号和信息 | 1638338-43-8 |
| 分子类型 | 抗体 |
Navicixizumab (anti-DLL4) (Ab176598) - Flow Cytometry
Flow Cytometry analysis of HUVEC cells labelling DLL4 (red) with Navicixizumab (anti-DLL4) (Ab176598). Goat Anti-Human IgG (PE) (Ab175838) at a dilution of 1/1000 was used as the secondary antibody. Blue - Isotype control, human IgG (Ab170213). Black - Unlabelled control, cells without incubation with primary antibody.
Navicixizumab (anti-DLL4) (Ab176598) - SEC
The purity of Navicixizumab (anti-DLL4) (Ab176598) is more than 95% verified by HPLC.
Navicixizumab (anti-DLL4) (Ab176598) - ELISA
Immobilized human-DLL4-his a at 2.0 μg/mL can bind Navicixizumab (anti-DLL4) (Ab176598) with the EC₅₀ of 36.01 ng/mL.
| 作用机制 | Action Type | target ID | Target Name | Target Type | Target Organism | Binding Site Name | 参考文献 |
|---|
通过匹配包装上的批号来查找并下载产品的 COA，每批产品都进行了严格的验证，您可放心使用！
| 批号(Lot Number) | 证书类型 | 日期 | 货号 |
|---|---|---|---|
 ZJ24F1114090 |
分析证书 | 24-11-21 | Ab176598 |
| ZJ24F1114089 |
分析证书 | 24-11-21 | Ab176598 |
| ZJ24F1114088 |
分析证书 | 24-11-21 | Ab176598 |
| ZJ24F0404416 |
分析证书 | 24-04-11 | Ab176598 |
| ZJ24F0404415 |
分析证书 | 24-04-11 | Ab176598 |
| ZJ24F0404414 |
分析证书 | 24-04-11 | Ab176598 |
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| 1. Shutter JR, Scully S, Fan W, Richards WG, Kitajewski J, Deblandre GA, Kintner CR, Stark KL. (2000) Dll4, a novel Notch ligand expressed in arterial endothelium.. Genes Dev, 14 (11): (1313-8). [PMID:10837024] |
| 2. Yoneya, T T and 7 more authors.. (2001) Molecular cloning of delta-4, a new mouse and human Notch ligand.. Journal of biochemistry, [PMID:11134954] |
| 3. Del Barrio, Marta G MG and 10 more authors.. (2007) A regulatory network involving Foxn4, Mash1 and delta-like 4/Notch1 generates V2a and V2b spinal interneurons from a common progenitor pool.. Development (Cambridge, England), [PMID:17728344] |
| 4. Brütsch, René R and 8 more authors.. (2010) Integrin cytoplasmic domain-associated protein-1 attenuates sprouting angiogenesis.. Circulation research, (3): [PMID:20616313] |
| 5. Meester, Josephina A N JA and 23 more authors.. (2015) Heterozygous Loss-of-Function Mutations in DLL4 Cause Adams-Oliver Syndrome.. American journal of human genetics, (3): [PMID:26299364] |
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