货号 (SKU)

包装规格

是否现货

价格

数量

Ab176557-100μg

100μg

现货

Ab176557-1mg

1mg

现货

Ab176557-5mg

5mg

现货

Ab176557-10mg

10mg

期货

基本信息

产品名称	Narsoplimab (anti-MASP2), 甘露结合凝集素丝氨酸蛋白酶 2 抑制剂
别名	纳索利单抗 \| 纳索普利单抗（抗 MASP2）
英文别名	Mannan binding lectin serine peptidase 2 antibody \| Mannan binding lectin serine protease 2 antibody \| Mannose binding protein associated serine protease 2 antibody \| MAP 19 antibody \| MAP19 antibody \| MASP 2 antibody \| MBL associated plasma protein of 19
规格或纯度	无载体, 重组, ExactAb™, 低内毒素, 无叠氮钠, 已验证, 无动物源, ≥95%(SDS-PAGE&SEC-HPLC), 见COA
宿主种属	人(Human)
特异性	MASP2
种属反应性	人(Human),大鼠(Rat),小鼠(Mouse),恒河猴(Rhesus monkey),食蟹猴(Cynomolgus monkey)
偶联	Unconjugated
作用类型	抑制剂
作用机制	甘露结合凝集素丝氨酸蛋白酶 2 抑制剂

产品属性

克隆类型	重组抗体
Format	Whole IgG
亚型	Human IgG4SP
轻链亚型	lambdaC2
SDS-PAGE	28.3 kDa (Light Chain) & 51.6 kDa (Heavy Chain), under reducing conditions; 178.5 kDa, under non-reducing conditions.
纯化方法	Protein A purified
纯度	>95%
物理外观	Liquid
储存缓冲液	Supplied as a 0.22 μm filtered solution in 100mM Pro-Ac, 20mM Arg, pH 5.0
防腐剂	No
浓度	见COA
储存温度	-80℃储存,避免反复冻融
运输条件	超低温冰袋运输
稳定性与储存	在 -80℃ 下保存 24 个月。收货后建议分装。避免冷冻/解冻循环。
CAS编号和信息	2108782-45-0
分子类型	抗体

图片

SEC: Narsoplimab (anti-MASP2) (Ab176557)

Narsoplimab (anti-MASP2) (Ab176557) - SEC
The purity of Narsoplimab (anti-MASP2) (Ab176557) is more than 95% verified by HPLC.

ELISA: Narsoplimab (anti-MASP2) (Ab176557)

Narsoplimab (anti-MASP2) (Ab176557) - ELISA
Immobilized huMASP-2A-chis at 2 μg/mL can bind Narsoplimab (anti-MASP2) (Ab176557) with the EC₅₀ of 6.3 ng/mL.

关联靶点（人）

MASP2 Tchem 甘露聚糖结合凝集素丝氨酸蛋白酶 2(Mannan-binding lectin serine protease 2) (0 活性数据)

点击查看靶蛋白信息： MASP2

活性类型	活性值-log(M)	作用机制	期刊	参考文献(PubMed IDs)

作用机制

作用机制	Action Type	target ID	Target Name	Target Type	Target Organism	Binding Site Name	参考文献

安全和危险性（GHS）

SDS英文版

质量标准

质量标准

质检证书（CoA,COO,BSE/TSE 和分析图谱)

C of A & Other Certificates(BSE/TSE, COO):

输入批号以搜索分析图谱:

通过匹配包装上的批号来查找并下载产品的 COA，每批产品都进行了严格的验证，您可放心使用！

找到5个结果

批号(Lot Number)	证书类型	日期	货号
ZJ24F1012798	分析证书	24-10-24	Ab176557
ZJ24F1012797	分析证书	24-10-24	Ab176557
ZJ24F1012796	分析证书	24-10-24	Ab176557
ZJ23F1001468	分析证书	23-11-01	Ab176557
ZJ23F1001467	分析证书	23-11-01	Ab176557

参考文献

1. Rasmussen, H H HH, Orntoft, T F TF, Wolf, H H and Celis, J E JE.. (1996) Towards a comprehensive database of proteins from the urine of patients with bladder cancer.. The Journal of urology, [PMID:8618346]
2. Thiel, S S and 11 more authors.. (1997) A second serine protease associated with mannan-binding lectin that activates complement.. Nature, (3): [PMID:9087411]
3. Stover, C M CM and 6 more authors.. (1999) Two constituents of the initiation complex of the mannan-binding lectin activation pathway of complement are encoded by a single structural gene.. Journal of immunology (Baltimore, Md. : 1950), (15): [PMID:10092804]
4. Takahashi, M M, Endo, Y Y, Fujita, T T and Matsushita, M M.. (1999) A truncated form of mannose-binding lectin-associated serine protease (MASP)-2 expressed by alternative polyadenylation is a component of the lectin complement pathway.. International immunology, [PMID:10330290]
5. Matsushita, M M, Thiel, S S, Jensenius, J C JC, Terai, I I and Fujita, T T.. (2000) Proteolytic activities of two types of mannose-binding lectin-associated serine protease.. Journal of immunology (Baltimore, Md. : 1950), (1): [PMID:10946292]
6. Stover, C C and 12 more authors.. (2001) The human gene for mannan-binding lectin-associated serine protease-2 (MASP-2), the effector component of the lectin route of complement activation, is part of a tightly linked gene cluster on chromosome 1p36.2-3.. Genes and immunity, [PMID:11426320]
7. Stengaard-Pedersen, Kristian K and 8 more authors.. (2003) Inherited deficiency of mannan-binding lectin-associated serine protease 2.. The New England journal of medicine, (7): [PMID:12904520]
8. Gregory, Lynn A LA and 6 more authors.. (2004) The X-ray structure of human mannan-binding lectin-associated protein 19 (MAp19) and its interaction site with mannan-binding lectin and L-ficolin.. The Journal of biological chemistry, (9): [PMID:15117939]
9. Harmat, Veronika V and 7 more authors.. (2004) The structure of MBL-associated serine protease-2 reveals that identical substrate specificities of C1s and MASP-2 are realized through different sets of enzyme-substrate interactions.. Journal of molecular biology, (1): [PMID:15364579]
10. Lozano, F F and 6 more authors.. (2005) Novel MASP2 variants detected among North African and Sub-Saharan individuals.. Tissue antigens, [PMID:16029433]
11. Gál, Péter P and 10 more authors.. (2005) A true autoactivating enzyme. Structural insight into mannose-binding lectin-associated serine protease-2 activations.. The Journal of biological chemistry, (30): [PMID:16040602]
12. Thiel, S S and 9 more authors.. (2007) Deficiency of mannan-binding lectin associated serine protease-2 due to missense polymorphisms.. Genes and immunity, [PMID:17252003]
13. Srour, M M and 9 more authors.. (2015) A homozygous mutation in SLC1A4 in siblings with severe intellectual disability and microcephaly.. Clinical genetics, [PMID:25930971]
14. Elhadad, S and 5 more authors.. (2021) MASP2 levels are elevated in thrombotic microangiopathies: association with microvascular endothelial cell injury and suppression by anti-MASP2 antibody narsoplimab.. Clinical and experimental immunology, [PMID:32681658]

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Narsoplimab (anti-MASP2), 甘露结合凝集素丝氨酸蛋白酶 2 抑制剂

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关联靶点（人）

作用机制

安全和危险性（GHS）

质量标准

质检证书（CoA,COO,BSE/TSE 和分析图谱)

参考文献

溶液计算器

摩尔浓度计算器

稀释计算器

复溶计算器

Narsoplimab (anti-MASP2), 甘露结合凝集素丝氨酸蛋白酶 2 抑制剂

库存信息

库存信息

库存信息

库存信息

基本信息

产品属性

图片

关联靶点（人）

作用机制

安全和危险性（GHS）

质量标准

质检证书（CoA,COO,BSE/TSE 和分析图谱)

相关产品

参考文献

溶液计算器

摩尔浓度计算器

稀释计算器

复溶计算器