产品名称	Refanezumab (anti-MAG), 髓鞘相关糖蛋白抑制剂
别名	瑞法奈珠单抗 \| 雷法尼珠单抗（抗 MAG）
英文别名	GMA antibody \| MAG antibody \| MAG_HUMAN antibody \| Myelin associated glycoprotein antibody \| Myelin-associated glycoprotein antibody \| S MAG antibody \| S-MAG antibody \| Sialic acid binding Ig like lectin 4A antibody \| Sialic acid binding immunoglobulin li
规格或纯度	无载体, 重组, ExactAb™, 低内毒素, 无叠氮钠, 已验证, 无动物源, ≥95%(SDS-PAGE&SEC-HPLC), 见COA
宿主种属	人(Human)
特异性	MAG
种属反应性	人(Human),大鼠(Rat)
偶联	Unconjugated
作用类型	抑制剂
作用机制	髓鞘相关糖蛋白抑制剂

产品属性

克隆类型	重组抗体
Format	Whole IgG
亚型	Human IgG1
轻链亚型	kappa
SDS-PAGE	27.4 kDa (Light Chain) & 52.3 kDa (Heavy Chain), under reducing conditions; 180.0 kDa, under non-reducing conditions.
纯化方法	Protein A purified
纯度	>95%
物理外观	Liquid
储存缓冲液	Supplied as a 0.22 μm filtered solution in 50mM Pro-Ac, 20mM Arg, pH 5.0
防腐剂	No
浓度	见COA
储存温度	-80℃储存,避免反复冻融
运输条件	超低温冰袋运输
稳定性与储存	在 -80℃ 下保存 24 个月。收货后建议分装。避免冷冻/解冻循环。
CAS编号和信息	1233953-61-1
分子类型	抗体

图片

ELISA: Refanezumab (anti-MAG) (Ab176431)

Refanezumab (anti-MAG) (Ab176431) - ELISA
Immobilized Human MAG-Fc tag 2 μg/mL can bind Refanezumab (anti-MAG) (Ab176431) with the EC₅₀ of 7.49 ng/mL.

SEC: Refanezumab (anti-MAG) (Ab176431)

Refanezumab (anti-MAG) (Ab176431) - SEC
The purity of Refanezumab (anti-MAG) (Ab176431) is more than 95% verified by HPLC.

关联靶点（人）

MAG Tchem 髓鞘相关糖蛋白(Myelin-associated glycoprotein) (0 活性数据)

点击查看靶蛋白信息： MAG

活性类型	活性值-log(M)	作用机制	期刊	参考文献(PubMed IDs)

作用机制

作用机制	Action Type	target ID	Target Name	Target Type	Target Organism	Binding Site Name	参考文献

安全和危险性（GHS）

SDS英文版

质量标准

质量标准

质检证书（CoA,COO,BSE/TSE 和分析图谱)

C of A & Other Certificates(BSE/TSE, COO):

输入批号以搜索分析图谱:

通过匹配包装上的批号来查找并下载产品的 COA，每批产品都进行了严格的验证，您可放心使用！

找到6个结果

批号(Lot Number)	证书类型	日期	货号
ZJ24F1113265	分析证书	24-11-04	Ab176431
ZJ24F1113264	分析证书	24-11-04	Ab176431
ZJ24F1113263	分析证书	24-11-04	Ab176431
ZJ24F0404144	分析证书	24-04-03	Ab176431
ZJ24F0404143	分析证书	24-04-03	Ab176431
ZJ24F0404142	分析证书	24-04-03	Ab176431

参考文献

1. Abdu-Allah HH, Watanabe K, Completo GC, Sadagopan M, Hayashizaki K, Takaku C, Tamanaka T, Takematsu H, Kozutsumi Y, Paulson JC, Tsubata T, Ando H, Ishida H, Kiso M.. (2011) CD22-antagonists with nanomolar potency: the synergistic effect of hydrophobic groups at C-2 and C-9 of sialic acid scaffold.. Bioorg Med Chem, 19 (6): (1966-1971). [PMID:21349726] [10.1016/j.bmc.2011.01.060]
2. Abdu-Allah HHM,Wu SC,Lin CH,Tseng YY. (2020) Design, synthesis and molecular docking study of α-triazolylsialosides as non-hydrolyzable and potent CD22 ligands.. Eur J Med Chem, 208 (112707-112707). [PMID:32942185] [10.1016/j.ejmech.2020.112707]
3. Sato, S S and 6 more authors.. (1989) cDNA cloning and amino acid sequence for human myelin-associated glycoprotein.. Biochemical and biophysical research communications, (29): [PMID:2476987]
4. Spagnol, G G and 6 more authors.. (1989) Molecular cloning of human myelin-associated glycoprotein.. Journal of neuroscience research, [PMID:2479762]
5. Favilla, J T JT and 5 more authors.. (1984) Myelin-associated glycoprotein (MAG) distribution in human central nervous tissue studied immunocytochemically with monoclonal antibody.. Journal of neuroimmunology, [PMID:6200494]
6. Burger, D D, Pidoux, L L and Steck, A J AJ.. (1993) Identification of the glycosylated sequons of human myelin-associated glycoprotein.. Biochemical and biophysical research communications, (15): [PMID:7505568]
7. Budel, Stéphane S and 18 more authors.. (2008) Genetic variants of Nogo-66 receptor with possible association to schizophrenia block myelin inhibition of axon growth.. The Journal of neuroscience : the official journal of the Society for Neuroscience, (3): [PMID:19052207]
8. Novarino, Gaia G and 51 more authors.. (2014) Exome sequencing links corticospinal motor neuron disease to common neurodegenerative disorders.. Science (New York, N.Y.), (31): [PMID:24482476]
9. Lossos, Alexander A and 21 more authors.. (2015) Myelin-associated glycoprotein gene mutation causes Pelizaeus-Merzbacher disease-like disorder.. Brain : a journal of neurology, [PMID:26179919]
10. Roda, Ricardo H RH, FitzGibbon, Edmond J EJ, Boucekkine, Houda H, Schindler, Alice B AB and Blackstone, Craig C.. (2016) Neurologic syndrome associated with homozygous mutation at MAG sialic acid binding site.. Annals of clinical and translational neurology, [PMID:27606346]

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Refanezumab (anti-MAG), 髓鞘相关糖蛋白抑制剂

库存信息

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库存信息

库存信息

基本信息

产品属性

图片

关联靶点（人）

作用机制

安全和危险性（GHS）

质量标准

质检证书（CoA,COO,BSE/TSE 和分析图谱)

相关产品

参考文献

溶液计算器

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