| 货号 (SKU) | 包装规格 | 是否现货 | 价格 | 数量 |
|---|---|---|---|---|
| Ab176427-100μg |
100μg |
现货  |
| |
| Ab176427-1mg |
1mg |
现货 |
| |
| Ab176427-5mg |
5mg |
现货 |
| |
| Ab176427-10mg |
10mg |
期货 |
|
| 产品名称 | Pepinemab (anti-SEMA4D), 抑制剂 Semaphorin-4D 抑制剂 |
|---|---|
| 别名 | 派比奈单抗 | Pepinemab（抗 SEMA4D） |
| 英文别名 | A8 antibody | BB 18 antibody | BB18 antibody | CD 100 antibody | CD100 antibody | CD100 antigen antibody | Coll 4 antibody | COLL4 antibody | Collapsin 4 antibody | Collapsin4 antibody | GR3 antibody | Leukocyte activation antigen CD100 antibody | M sema |
| 规格或纯度 | 无载体, 重组, ExactAb™, 低内毒素, 无叠氮钠, 已验证, 无动物源, ≥95%(SDS-PAGE&SEC-HPLC), 见COA |
| 宿主种属 | 人(Human) |
| 特异性 | SEMA4D |
| 种属反应性 | 人(Human),小鼠(Mouse) |
| 偶联 | Unconjugated |
| 作用类型 | 抑制剂 |
| 作用机制 | 抑制剂 Semaphorin-4D 抑制剂 |
| 克隆类型 | 重组抗体 |
|---|---|
| Format | Whole IgG |
| 亚型 | Human IgG4SP |
| 轻链亚型 | kappa |
| SDS-PAGE | 145.88 kDa |
| 纯化方法 | Protein A purified |
| 纯度 | >95% |
| 物理外观 | Liquid |
| 储存缓冲液 | Supplied as a 0.22 μm filtered solution in 50mM Pro-Ac, 20mM Arg, pH 5.0 |
| 防腐剂 | No |
| 浓度 | 见COA |
| 储存温度 | -80℃储存,避免反复冻融 |
| 运输条件 | 超低温冰袋运输 |
| 稳定性与储存 | 在 -80℃ 下保存 24 个月。收货后建议分装。避免冷冻/解冻循环。 |
| 分子类型 | 抗体 |
Pepinemab (anti-SEMA4D) (Ab176427) - Flow Cytometry
Flow Cytometry analysis of human peripheral blood lymphocytes labelling SEMA4D with Pepinemab (anti-SEMA4D) (Ab176427) conjugated with biotin (right panel) compared with Human IgG (Ab170213) conjugated with biotin - Isotype Control (left panel) and detected with SA-PE (rp156150).
Pepinemab (anti-SEMA4D) (Ab176427) - Flow Cytometry
Flow Cytometry analysis of human peripheral blood lymphocytes labelling SEMA4D (red) with Pepinemab (anti-SEMA4D) (Ab176427) conjugated with biotin and detected with SA-PE (rp156150). Blue - Isotype control, human IgG (Ab170213) conjugated with biotin. Black - Unlabelled control, cells without incubation with primary antibody.
Pepinemab (anti-SEMA4D) (Ab176427) - SEC
The purity of Pepinemab (anti-SEMA4D) (Ab176427) is more than 95% verified by HPLC.
| 作用机制 | Action Type | target ID | Target Name | Target Type | Target Organism | Binding Site Name | 参考文献 |
|---|
通过匹配包装上的批号来查找并下载产品的 COA，每批产品都进行了严格的验证，您可放心使用！
| 批号(Lot Number) | 证书类型 | 日期 | 货号 |
|---|---|---|---|
 ZJ24F0911268 |
分析证书 | 24-09-26 | Ab176427 |
| ZJ24F0911269 |
分析证书 | 24-09-26 | Ab176427 |
| ZJ24F0911270 |
分析证书 | 24-09-26 | Ab176427 |
| ZJ23F1001511 |
分析证书 | 23-11-02 | Ab176427 |
| ZJ23F1001512 |
分析证书 | 23-11-02 | Ab176427 |
| 1. Hall KT, Boumsell L, Schultze JL, Boussiotis VA, Dorfman DM, Cardoso AA, Bensussan A, Nadler LM, Freeman GJ. (1996) Human CD100, a novel leukocyte semaphorin that promotes B-cell aggregation and differentiation.. Proc Natl Acad Sci USA, 93 (21): (11780-5). [PMID:8876214] |
| 2. Fisher TL, Reilly CA, Winter LA, Pandina T, Jonason A, Scrivens M, Balch L, Bussler H, Torno S, Seils J et al.. (2016) Generation and preclinical characterization of an antibody specific for SEMA4D.. MAbs, 8 (1): (150-62). [PMID:26431358] |
| 3. Tamagnone, L L and 11 more authors.. (1999) Plexins are a large family of receptors for transmembrane, secreted, and GPI-anchored semaphorins in vertebrates.. Cell, (1): [PMID:10520995] |
| 4. Love, Christopher A CA and 6 more authors.. (2003) The ligand-binding face of the semaphorins revealed by the high-resolution crystal structure of SEMA4D.. Nature structural biology, [PMID:12958590] |
| 5. Basile, John R JR, Afkhami, Talayeh T and Gutkind, J Silvio JS.. (2005) Semaphorin 4D/plexin-B1 induces endothelial cell migration through the activation of PYK2, Src, and the phosphatidylinositol 3-kinase-Akt pathway.. Molecular and cellular biology, [PMID:16055703] |
| 6. Lewandrowski, Urs U, Moebius, Jan J, Walter, Ulrich U and Sickmann, Albert A.. (2006) Elucidation of N-glycosylation sites on human platelet proteins: a glycoproteomic approach.. Molecular & cellular proteomics : MCP, [PMID:16263699] |
| 7. Wollscheid, Bernd B and 7 more authors.. (2009) Mass-spectrometric identification and relative quantification of N-linked cell surface glycoproteins.. Nature biotechnology, [PMID:19349973] |
| 8. Vodrazka, Peter P and 9 more authors.. (2009) The semaphorin 4D-plexin-B signalling complex regulates dendritic and axonal complexity in developing neurons via diverse pathways.. The European journal of neuroscience, [PMID:19788569] |
| 9. Janssen, Bert J C BJ and 6 more authors.. (2010) Structural basis of semaphorin-plexin signalling.. Nature, (28): [PMID:20877282] |
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