Flanvotumab (anti-TYRP1), 其他 5,6-二羟基吲哚-2-羧酸氧化酶的 OTHER

    应用:
  • Animal Model
  • ELISA
  • Flow Cytometry
  • Functional Assay
功能和特点
  • 宿主种属: 人(Human)
  • 种属反应性: 人(Human), 小鼠(Mouse)
  • 亚型: Human IgG1
  • 偶联: Unconjugated
有货

库存信息

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库存信息

关闭

库存信息

关闭

库存信息

关闭
货号 (SKU) 包装规格 是否现货 价格 数量
Ab176073-100μg
100μg 现货 Stock Image
Ab176073-1mg
1mg 现货 Stock Image
Ab176073-5mg
5mg 现货 Stock Image
Ab176073-10mg
10mg 期货 Stock Image

基本信息

产品名称 Flanvotumab (anti-TYRP1), 其他 5,6-二羟基吲哚-2-羧酸氧化酶的 OTHER
别名 法兰妥单抗 | 氟妥珠单抗(抗 TYRP1)
英文别名 5 antibody | 5,6 dihydroxyindole 2 carboxylic acid oxidase antibody | 6-dihydroxyindole-2-carboxylic acid oxidase antibody | b-PROTEIN antibody | CAS2 antibody | Catalase B antibody | CATB antibody | DHICA oxidase antibody | Glycoprotein 75 antibody | GP7
规格或纯度 无载体, 重组, ExactAb™, 低内毒素, 无叠氮钠, 已验证, 无动物源, ≥95%(SDS-PAGE&SEC-HPLC), 见COA
宿主种属 人(Human)
特异性 TYRP1
种属反应性 人(Human),小鼠(Mouse)
偶联 Unconjugated
作用类型 其它
作用机制 其他 5,6-二羟基吲哚-2-羧酸氧化酶的 OTHER

产品属性

克隆类型 重组抗体
Format Whole IgG
亚型 Human IgG1
轻链亚型 kappa
SDS-PAGE 26.8 kDa (Light Chain) & 51.0 kDa (Heavy Chain), under reducing conditions; 171.0 kDa, under non-reducing conditions.
纯化方法 Protein A purified
纯度 >95%
物理外观 Liquid
储存缓冲液 Supplied as a 0.22 μm filtered solution in 50mM Pro-Ac, 20mM Arg, pH 5.0
防腐剂 No
浓度 见COA
储存温度 -80℃储存,避免反复冻融
运输条件 超低温冰袋运输
稳定性与储存 在 -80℃ 下保存 24 个月。收货后建议分装。避免冷冻/解冻循环。
CAS编号和信息 1188277-05-5
分子类型 抗体

图片

Flanvotumab (anti-TYRP1) (Ab176073) - SEC
The purity of Flanvotumab (anti-TYRP1) (Ab176073) is more than 95% verified by HPLC.

关联靶点(人)

TYRP1 Tbio 5,6-二羟基吲哚-2-羧酸氧化酶(5,6-dihydroxyindole-2-carboxylic acid oxidase) (0 活性数据)
活性类型 活性值-log(M) 作用机制 期刊 参考文献(PubMed IDs)

作用机制

作用机制 Action Type target ID Target Name Target Type Target Organism Binding Site Name 参考文献

安全和危险性(GHS)

质量标准

质检证书(CoA,COO,BSE/TSE 和分析图谱)

C of A & Other Certificates(BSE/TSE, COO):
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通过匹配包装上的批号来查找并下载产品的 COA,每批产品都进行了严格的验证,您可放心使用!

找到3个结果

批号(Lot Number) 证书类型 日期 货号
ZJ24F0202867 分析证书 24-02-23 Ab176073
ZJ24F0202868 分析证书 24-02-23 Ab176073
ZJ24F0202866 分析证书 24-02-23 Ab176073

参考文献

1. Shibata, K K, Takeda, K K, Tomita, Y Y, Tagami, H H and Shibahara, S S..  (1992)  Downstream region of the human tyrosinase-related protein gene enhances its promoter activity..  Biochemical and biophysical research communications,  (30): [PMID:1575733]
2. Halaban, R R and Moellmann, G G..  (1990)  Murine and human b locus pigmentation genes encode a glycoprotein (gp75) with catalase activity..  Proceedings of the National Academy of Sciences of the United States of America,  [PMID:1693779]
3. Chintamaneni, C D CD and 5 more authors..  (1991)  Mapping the human CAS2 gene, the homologue of the mouse brown (b) locus, to human chromosome 9p22-pter..  Biochemical and biophysical research communications,  (15): [PMID:1906272]
4. and Urquhart, A A..  (1991)  Human tyrosinase-like protein (TYRL) carboxy terminus: closer homology with the mouse protein than previously reported..  Nucleic acids research,  (25): [PMID:1945866]
5. Cohen, T T, Muller, R M RM, Tomita, Y Y and Shibahara, S S..  (1990)  Nucleotide sequence of the cDNA encoding human tyrosinase-related protein..  Nucleic acids research,  (11): [PMID:2111010]
6. Vijayasaradhi, S S, Bouchard, B B and Houghton, A N AN..  (1990)  The melanoma antigen gp75 is the human homologue of the mouse b (brown) locus gene product..  The Journal of experimental medicine,  (1): [PMID:2324688]
7. Sturm, R A RA and 7 more authors..  (1995)  Chromosomal structure of the human TYRP1 and TYRP2 loci and comparison of the tyrosinase-related protein gene family..  Genomics,  (1): [PMID:8530077]
8. Box, N F NF and 5 more authors..  (1998)  Complete sequence and polymorphism study of the human TYRP1 gene encoding tyrosinase-related protein 1..  Mammalian genome : official journal of the International Mammalian Genome Society,  [PMID:9434945]
9. Boissy, R E RE, Sakai, C C, Zhao, H H, Kobayashi, T T and Hearing, V J VJ..  (1998)  Human tyrosinase related protein-1 (TRP-1) does not function as a DHICA oxidase activity in contrast to murine TRP-1..  Experimental dermatology,  [PMID:9758418]
10. Basrur, Venkatesha V and 12 more authors.. Proteomic analysis of early melanosomes: identification of novel melanosomal proteins..  Journal of proteome research,  [PMID:12643545]
11. Rooryck, Caroline C, Roudaut, Christel C, Robine, Eulalie E, Müsebeck, Jörg J and Arveiler, Benoît B..  (2006)  Oculocutaneous albinism with TYRP1 gene mutations in a Caucasian patient..  Pigment cell research,  [PMID:16704458]
12. Chi, An A and 16 more authors..  (2006)  Proteomic and bioinformatic characterization of the biogenesis and function of melanosomes..  Journal of proteome research,  [PMID:17081065]
13. Kenny, Eimear E EE and 10 more authors..  (2012)  Melanesian blond hair is caused by an amino acid change in TYRP1..  Science (New York, N.Y.),  (4): [PMID:22556244]
14. Simeonov, Dimitre R DR and 15 more authors..  (2013)  DNA variations in oculocutaneous albinism: an updated mutation list and current outstanding issues in molecular diagnostics..  Human mutation,  [PMID:23504663]
15. Lai, Xuelei; Wichers, Harry J; Soler-Lopez, Montserrat and Dijkstra, Bauke W..  (2017)  Structure of Human Tyrosinase Related Protein 1 Reveals a Binuclear Zinc Active Site Important for Melanogenesis..  Angewandte Chemie (International ed. in English),  (7): [PMID:28661582]

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