Polatuzumab (anti-CD79b)

    应用:
  • Animal Model
  • ELISA
  • Flow Cytometry
  • Functional Assay
功能和特点
  • 宿主种属: 人(Human)
  • 种属反应性: 人(Human), 小鼠(Mouse), 食蟹猴(Cynomolgus monkey)
  • 亚型: Human IgG1
  • 偶联: Unconjugated
有货

库存信息

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库存信息

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库存信息

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库存信息

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货号 (SKU) 包装规格 是否现货 价格 数量
Ab175715-100μg
100μg 现货 Stock Image
Ab175715-1mg
1mg 现货 Stock Image
Ab175715-5mg
5mg 现货 Stock Image
Ab175715-10mg
10mg 期货 Stock Image

基本信息

产品名称 Polatuzumab (anti-CD79b)
别名 泊洛妥珠单抗 | 波拉珠单抗(抗 CD79b)
英文别名 AGM6 antibody | B cell antigen receptor complex associated protein beta chain antibody | B cell specific glycoprotein B29 antibody | B-cell antigen receptor complex-associated protein beta chain antibody | B-cell-specific glycoprotein B29 antibody | B29 a
规格或纯度 无载体, 重组, ExactAb™, 无叠氮钠, 已验证, 无动物源, ≥95%(SDS-PAGE&SEC-HPLC), 见COA
宿主种属 人(Human)
特异性 CD79B
种属反应性 人(Human),小鼠(Mouse),食蟹猴(Cynomolgus monkey)
偶联 Unconjugated

产品属性

克隆类型 重组抗体
Format Whole IgG
亚型 Human IgG1
轻链亚型 kappa
SDS-PAGE 27.4 kDa (Light Chain) & 51.8 kDa (Heavy Chain), under reducing conditions; 180.0 kDa, under non-reducing conditions.
纯化方法 Protein A purified
纯度 >95% (SDS-PAGE&SEC)
物理外观 Liquid
储存缓冲液 Supplied as a 0.22 μm filtered solution in 100mM Pro-Ac, 20mM Arg, pH 5.0
防腐剂 No
浓度 见COA
储存温度 -80℃储存,避免反复冻融
运输条件 超低温冰袋运输
稳定性与储存 在 -80℃ 下保存 24 个月。收货后建议分装。避免冷冻/解冻循环。
CAS编号和信息 2279068-37-8
分子类型 抗体

图片

Polatuzumab (anti-CD79b) (Ab175715) - ELISA
Immobilized hu-CD79b-His at 2 μg/mL can bind Polatuzumab (anti-CD79b) (Ab175715) with the EC₅₀ of 4.09 ng/mL.

Polatuzumab (anti-CD79b) (Ab175715) - SEC
The purity of Polatuzumab (anti-CD79b) (Ab175715) is more than 95% verified by HPLC.

Recombinant Human CD79B Protein (rp176729) - ELISA
Immobilized Recombinant Human CD79B Protein (rp176729) at 1.0 μg/mL can bind Polatuzumab (anti-CD79b) (Ab175715) with the EC50 of 11.08 ng/mL.

关联靶点(人)

CD79B Tclin B 细胞抗原受体复合物相关蛋白 β 链(B-cell antigen receptor complex-associated protein beta chain) (0 活性数据)
活性类型 活性值-log(M) 作用机制 期刊 参考文献(PubMed IDs)

作用机制

作用机制 Action Type target ID Target Name Target Type Target Organism Binding Site Name 参考文献

安全和危险性(GHS)

质量标准

质检证书(CoA,COO,BSE/TSE 和分析图谱)

C of A & Other Certificates(BSE/TSE, COO):
输入批号以搜索分析图谱:

通过匹配包装上的批号来查找并下载产品的 COA,每批产品都进行了严格的验证,您可放心使用!

找到3个结果

批号(Lot Number) 证书类型 日期 货号
ZJ24F0303075 分析证书 24-03-08 Ab175715
ZJ24F0303074 分析证书 24-03-08 Ab175715
ZJ24F0303073 分析证书 24-03-08 Ab175715

参考文献

1. Müller, B B, Cooper, L L and Terhorst, C C..  (1992)  Cloning and sequencing of the cDNA encoding the human homologue of the murine immunoglobulin-associated protein B29..  European journal of immunology,  [PMID:1534761]
2. Vasile, S S, Coligan, J E JE, Yoshida, M M and Seon, B K BK..  (1994)  Isolation and chemical characterization of the human B29 and mb-1 proteins of the B cell antigen receptor complex..  Molecular immunology,  [PMID:7514267]
3. Hashimoto, S S, Chiorazzi, N N and Gregersen, P K PK..  (1995)  Alternative splicing of CD79a (Ig-alpha/mb-1) and CD79b (Ig-beta/B29) RNA transcripts in human B cells..  Molecular immunology,  [PMID:7643857]
4. Hashimoto, S S, Chiorazzi, N N and Gregersen, P K PK..  (1994)  The complete sequence of the human CD79b (Ig beta/B29) gene: identification of a conserved exon/intron organization, immunoglobulin-like regulatory regions, and allelic polymorphism..  Immunogenetics,  [PMID:7913081]
5. Hashimoto, S S, Gregersen, P K PK and Chiorazzi, N N..  (1993)  The human Ig-beta cDNA sequence, a homologue of murine B29, is identical in B cell and plasma cell lines producing all the human Ig isotypes..  Journal of immunology (Baltimore, Md. : 1950),  (15): [PMID:8419481]
6. Wood, W J WJ and 6 more authors..  (1993)  Isolation and chromosomal mapping of the human immunoglobulin-associated B29 gene (IGB)..  Genomics,  [PMID:8486355]
7. Dobbs, A Kerry and 5 more authors..  (2007)  Cutting edge: a hypomorphic mutation in Igbeta (CD79b) in a patient with immunodeficiency and a leaky defect in B cell development..  Journal of immunology (Baltimore, Md. : 1950),  (15): [PMID:17675462]

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