货号 (SKU)

包装规格

是否现货

价格

数量

Ab175625-100μg

100μg

现货

Ab175625-1mg

1mg

现货

Ab175625-5mg

5mg

现货

Ab175625-10mg

10mg

期货

基本信息

产品名称	Pascolizumab (anti-IL-4), 白细胞介素-4 抑制剂
别名	帕考珠单抗 \| 帕考珠单抗(抗 IL-4)
英文别名	B cell growth factor 1 antibody \| B cell IgG differentiation factor antibody \| B Cell Stimulatory Factor 1 antibody \| B-cell stimulatory factor 1 antibody \| BCGF 1 antibody \| BCGF1 antibody \| Binetrakin antibody \| BSF-1 antibody \| BSF1 antibody \| IGG1 ind
规格或纯度	无载体, 重组, ExactAb™, 低内毒素, 无叠氮钠, 已验证, 无动物源, ≥95%(SDS-PAGE&SEC-HPLC), 见COA
宿主种属	人(Human)
特异性	IL4
种属反应性	人(Human),小鼠(Mouse)
偶联	Unconjugated
作用类型	抑制剂
作用机制	白细胞介素-4 抑制剂

产品属性

克隆类型	重组抗体
Format	Whole IgG
亚型	Human IgG1
轻链亚型	kappa
SDS-PAGE	26.6 kDa (Light Chain) & 51.1 kDa (Heavy Chain), under reducing conditions; 176.4 kDa, under non-reducing conditions.
纯化方法	Protein A purified
纯度	>95%
物理外观	Liquid
储存缓冲液	Supplied as a 0.22μm filtered solution in 100mM Pro-Ac, 20mM Arg, pH 5.0
防腐剂	No
浓度	见COA
储存温度	-80℃储存,避免反复冻融
运输条件	超低温冰袋运输
稳定性与储存	在 -80℃ 下保存 24 个月。收货后建议分装。避免冷冻/解冻循环。
CAS编号和信息	331243-22-2
分子类型	抗体

图片

ELISA: Pascolizumab (anti-IL-4) (Ab175625)

Pascolizumab (anti-IL-4) (Ab175625) - ELISA
Immobilized hu-IL-4-his at 2.0 μg/mL can bind Pascolizumab (anti-IL-4) (Ab175625) with the EC₅₀ of 88.83 ng/mL.

SEC: Pascolizumab (anti-IL-4) (Ab175625)

Pascolizumab (anti-IL-4) (Ab175625) - SEC
The purity of Pascolizumab (anti-IL-4) (Ab175625) is more than 95% verified by HPLC.

关联靶点（人）

IL4 Tbio 白细胞介素-4(Interleukin-4) (0 活性数据)

点击查看靶蛋白信息： IL4

活性类型	活性值-log(M)	作用机制	期刊	参考文献(PubMed IDs)

作用机制

作用机制	Action Type	target ID	Target Name	Target Type	Target Organism	Binding Site Name	参考文献

安全和危险性（GHS）

SDS英文版

质量标准

质量标准

质检证书（CoA,COO,BSE/TSE 和分析图谱)

C of A & Other Certificates(BSE/TSE, COO):

输入批号以搜索分析图谱:

通过匹配包装上的批号来查找并下载产品的 COA，每批产品都进行了严格的验证，您可放心使用！

找到6个结果

批号(Lot Number)	证书类型	日期	货号
ZJ24F1114126	分析证书	24-11-21	Ab175625
ZJ24F1114125	分析证书	24-11-21	Ab175625
ZJ24F1114124	分析证书	24-11-21	Ab175625
ZJ24F0202892	分析证书	24-03-01	Ab175625
ZJ24F0202891	分析证书	24-03-01	Ab175625
ZJ24F0202890	分析证书	24-03-01	Ab175625

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参考文献

1. Hart TK, Blackburn MN, Brigham-Burke M, Dede K, Al-Mahdi N, Zia-Amirhosseini P, Cook RM. (2002) Preclinical efficacy and safety of pascolizumab (SB 240683): a humanized anti-interleukin-4 antibody with therapeutic potential in asthma.. Clin Exp Immunol, 130 (1): (93-100). [PMID:12296858]
2. Walter, M R MR and 9 more authors.. (1992) Crystal structure of recombinant human interleukin-4.. The Journal of biological chemistry, (5): [PMID:1400355]
3. Wlodawer, A A, Wlodaver, A A, Pavlovsky, A A and Gustchina, A A.. (1992) Crystal structure of human recombinant interleukin-4 at 2.25 A resolution.. FEBS letters, (31): [PMID:1511746]
4. Powers, R R and 5 more authors.. (1992) 1H, 15N, 13C, and 13CO assignments of human interleukin-4 using three-dimensional double- and triple-resonance heteronuclear magnetic resonance spectroscopy.. Biochemistry, (5): [PMID:1567880]
5. Garrett, D S DS and 5 more authors.. (1992) Determination of the secondary structure and folding topology of human interleukin-4 using three-dimensional heteronuclear magnetic resonance spectroscopy.. Biochemistry, (5): [PMID:1567881]
6. Smith, L J LJ and 6 more authors.. (1992) Human interleukin 4. The solution structure of a four-helix bundle protein.. Journal of molecular biology, (20): [PMID:1569578]
7. Redfield, C C and 6 more authors.. (1991) Secondary structure and topology of human interleukin 4 in solution.. Biochemistry, (19): [PMID:1932028]
8. Curtis, B M BM and 8 more authors.. (1991) Experimental and theoretical studies of the three-dimensional structure of human interleukin-4.. Proteins, [PMID:1946344]
9. Carr, C C, Aykent, S S, Kimack, N M NM and Levine, A D AD.. (1991) Disulfide assignments in recombinant mouse and human interleukin 4.. Biochemistry, (12): [PMID:1993171]
10. Arai, N N and 9 more authors.. (1989) Complete nucleotide sequence of the chromosomal gene for human IL-4 and its expression.. Journal of immunology (Baltimore, Md. : 1950), (1): [PMID:2535858]
11. Yokota, T T and 8 more authors.. (1986) Isolation and characterization of a human interleukin cDNA clone, homologous to mouse B-cell stimulatory factor 1, that expresses B-cell- and T-cell-stimulating activities.. Proceedings of the National Academy of Sciences of the United States of America, [PMID:3016727]
12. Eder, A A, Krafft-Czepa, H H and Krammer, P H PH.. (1988) The 5' region of the human interleukin 4 gene: structure and potential regulatory elements.. Nucleic acids research, (25): [PMID:3257560]
13. Smith, L J LJ and 8 more authors.. (1994) Comparison of four independently determined structures of human recombinant interleukin-4.. Nature structural biology, [PMID:7664036]
14. Klein, S C SC, Golverdingen, J G JG, Bouwens, A G AG, Tilanus, M G MG and de Weger, R A RA.. (1995) An alternatively spliced interleukin 4 form in lymphoid cells.. Immunogenetics, [PMID:7806280]
15. Müller, T T, Dieckmann, T T, Sebald, W W and Oschkinat, H H.. (1994) Aspects of receptor binding and signalling of interleukin-4 investigated by site-directed mutagenesis and NMR spectroscopy.. Journal of molecular biology, (8): [PMID:8151703]
16. Hage, T T, Sebald, W W and Reinemer, P P.. (1999) Crystal structure of the interleukin-4/receptor alpha chain complex reveals a mosaic binding interface.. Cell, (16): [PMID:10219247]
17. Hülsmeyer, M M, Scheufler, C C and Dreyer, M K MK.. (2001) Structure of interleukin 4 mutant E9A suggests polar steering in receptor-complex formation.. Acta crystallographica. Section D, Biological crystallography, [PMID:11526337]
18. Zee, Robert Y L RY and 6 more authors.. (2004) Polymorphism in the P-selectin and interleukin-4 genes as determinants of stroke: a population-based, prospective genetic analysis.. Human molecular genetics, (15): [PMID:14681304]
19. LaPorte, Sherry L SL and 7 more authors.. (2008) Molecular and structural basis of cytokine receptor pleiotropy in the interleukin-4/13 system.. Cell, (25): [PMID:18243101]
20. Powers, R R and 5 more authors.. (1992) Three-dimensional solution structure of human interleukin-4 by multidimensional heteronuclear magnetic resonance spectroscopy.. Science (New York, N.Y.), (19): [PMID:1609277]
21. Malabarba, M G MG and 7 more authors.. (1995) Activation of JAK3, but not JAK1, is critical to interleukin-4 (IL4) stimulated proliferation and requires a membrane-proximal region of IL4 receptor alpha.. The Journal of biological chemistry, (21): [PMID:7721895]

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所需的复溶浓度

Pascolizumab (anti-IL-4), 白细胞介素-4 抑制剂

库存信息

库存信息

库存信息

库存信息

基本信息

产品属性

图片

关联靶点（人）

作用机制

安全和危险性（GHS）

质量标准

质检证书（CoA,COO,BSE/TSE 和分析图谱)

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参考文献

溶液计算器

摩尔浓度计算器

稀释计算器

复溶计算器

Pascolizumab (anti-IL-4), 白细胞介素-4 抑制剂

库存信息

库存信息

库存信息

库存信息

基本信息

产品属性

图片

关联靶点（人）

作用机制

安全和危险性（GHS）

质量标准

质检证书（CoA,COO,BSE/TSE 和分析图谱)

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参考文献

溶液计算器

摩尔浓度计算器

稀释计算器

复溶计算器