货号 (SKU)

包装规格

是否现货

价格

数量

Ab175579-100μg

100μg

现货

Ab175579-1mg

1mg

现货

Ab175579-5mg

5mg

现货

Ab175579-10mg

10mg

期货

基本信息

产品名称	Ligelizumab (anti-IgE), 免疫球蛋白重常数ε抗体
别名	利戈组单抗 \| 利格利珠单抗 \| 利格珠单抗（抗 IgE）
英文别名	Igh2 antibody \| IGHE antibody \| IGHEP1 antibody \| Immunoglobulin heavy constant epsilon antibody \| IgE \| immunoglobulin heavy constant epsilon \| QGE 031 \| Anti-IGHE Recombinant Antibody \| Ig epsilon chain C region \| Ig epsilon chain C region ND
规格或纯度	无载体, 重组, ExactAb™, 低内毒素, 无叠氮钠, 已验证, 无动物源, ≥95%(SDS-PAGE&SEC-HPLC), 见COA
宿主种属	人(Human)
特异性	IGHE
种属反应性	人(Human)
偶联	Unconjugated
作用类型	抑制剂
作用机制	免疫球蛋白重常数ε抗体

产品属性

克隆类型	重组抗体
Format	Whole IgG
亚型	Human IgG1
轻链亚型	kappa
SDS-PAGE	26.8 kDa (Light Chain) & 51.5 kDa (Heavy Chain), under reducing conditions; 185.4 kDa, under non-reducing conditions.
纯化方法	Protein A purified
纯度	>95%
物理外观	Liquid
储存缓冲液	Supplied as a 0.22μm filtered solution in 100mM Pro-Ac, 20mM Arg, pH 5.0
防腐剂	No
浓度	见COA
储存温度	-80℃储存,避免反复冻融
运输条件	超低温冰袋运输
稳定性与储存	在 -80℃ 下保存 24 个月。收货后建议分装。避免冷冻/解冻循环。
CAS编号和信息	1322627-61-1
分子类型	抗体

图片

SEC: Ligelizumab (anti-IgE) (Ab175579)

Ligelizumab (anti-IgE) (Ab175579) - SEC
The purity of Ligelizumab (anti-IgE) (Ab175579) is more than 95% verified by HPLC.

关联靶点（人）

IGHE Tclin 免疫球蛋白重常数ε(Immunoglobulin heavy constant epsilon) (0 活性数据)

点击查看靶蛋白信息： IGHE

活性类型	活性值-log(M)	作用机制	期刊	参考文献(PubMed IDs)

作用机制

作用机制	Action Type	target ID	Target Name	Target Type	Target Organism	Binding Site Name	参考文献

安全和危险性（GHS）

SDS英文版

质量标准

质量标准

质检证书（CoA,COO,BSE/TSE 和分析图谱)

C of A & Other Certificates(BSE/TSE, COO):

输入批号以搜索分析图谱:

通过匹配包装上的批号来查找并下载产品的 COA，每批产品都进行了严格的验证，您可放心使用！

找到3个结果

批号(Lot Number)	证书类型	日期	货号
ZJ24F0405072	分析证书	24-04-30	Ab175579
ZJ24F0405071	分析证书	24-04-30	Ab175579
ZJ24F0405070	分析证书	24-04-30	Ab175579

可替换产品

参考文献

1. Maurer M, Weller K, Bindslev-Jensen C, Giménez-Arnau A, Bousquet PJ, Bousquet J, Canonica GW, Church MK, Godse KV, Grattan CE et al.. (2011) Unmet clinical needs in chronic spontaneous urticaria. A GA²LEN task force report.. Allergy, 66 (3): (317-30). [PMID:21083565]
2. Arm JP, Bottoli I, Skerjanec A, Floch D, Groenewegen A, Maahs S, Owen CE, Jones I, Lowe PJ. (2014) Pharmacokinetics, pharmacodynamics and safety of QGE031 (ligelizumab), a novel high-affinity anti-IgE antibody, in atopic subjects.. Clin Exp Allergy, 44 (11): (1371-85). [PMID:25200415]
3. Trischler J, Bottoli I, Janocha R, Heusser C, Jaumont X, Lowe P, Gautier A, Pethe A, Woessner R, Zerwes HG et al.. (2021) Ligelizumab treatment for severe asthma: learnings from the clinical development programme.. Clin Transl Immunology, 10 (3): (e1255). [PMID:33747510]
4. Batista FD, Anand S, Presani G, Efremov DG, Burrone OR. (1996) The two membrane isoforms of human IgE assemble into functionally distinct B cell antigen receptors.. J Exp Med, 184 (6): (2197-205). [PMID:8976175]
5. Gounni AS, Lamkhioued B, Ochiai K, Tanaka Y, Delaporte E, Capron A, Kinet JP, Capron M. (1994) High-affinity IgE receptor on eosinophils is involved in defence against parasites.. Nature, 367 (6459): (183-6). [PMID:8114916]
6. Zhang, K K, Saxon, A A and Max, E E EE.. (1992) Two unusual forms of human immunoglobulin E encoded by alternative RNA splicing of epsilon heavy chain membrane exons.. The Journal of experimental medicine, (1): [PMID:1613458]
7. Pirron, U U, Schlunck, T T, Prinz, J C JC and Rieber, E P EP.. (1990) IgE-dependent antigen focusing by human B lymphocytes is mediated by the low-affinity receptor for IgE.. European journal of immunology, [PMID:2167225]
8. Padlan, E A EA and Davies, D R DR.. (1986) A model of the Fc of immunoglobulin E.. Molecular immunology, [PMID:3796618]
9. Flanagan, J G JG and Rabbitts, T H TH.. (1982) The sequence of a human immunoglobulin epsilon heavy chain constant region gene, and evidence for three non-allelic genes.. The EMBO journal, [PMID:6234164]
10. Max, E E EE, Battey, J J, Ney, R R, Kirsch, I R IR and Leder, P P.. (1982) Duplication and deletion in the human immunoglobulin epsilon genes.. Cell, [PMID:6288268]
11. Seno, M M and 9 more authors.. (1983) Molecular cloning and nucleotide sequencing of human immunoglobulin epsilon chain cDNA.. Nucleic acids research, (11): [PMID:6300763]
12. Ueda, S S, Nakai, S S, Nishida, Y Y, Hisajima, H H and Honjo, T T.. (1982) Long terminal repeat-like elements flank a human immunoglobulin epsilon pseudogene that lacks introns.. The EMBO journal, [PMID:6327276]
13. Kenten, J H JH and 6 more authors.. (1982) Cloning and sequence determination of the gene for the human immunoglobulin epsilon chain expressed in a myeloma cell line.. Proceedings of the National Academy of Sciences of the United States of America, [PMID:6815656]
14. Vouldoukis, I I and 7 more authors.. (1995) The killing of Leishmania major by human macrophages is mediated by nitric oxide induced after ligation of the Fc epsilon RII/CD23 surface antigen.. Proceedings of the National Academy of Sciences of the United States of America, (15): [PMID:7544003]
15. Garman, S C SC, Wurzburg, B A BA, Tarchevskaya, S S SS, Kinet, J P JP and Jardetzky, T S TS.. (2000) Structure of the Fc fragment of human IgE bound to its high-affinity receptor Fc epsilonRI alpha.. Nature, (20): [PMID:10917520]
16. Heilig, Roland R and 98 more authors.. (2003) The DNA sequence and analysis of human chromosome 14.. Nature, (6): [PMID:12508121]
17. Hibbert, Richard G RG and 9 more authors.. (2005) The structure of human CD23 and its interactions with IgE and CD21.. The Journal of experimental medicine, (19): [PMID:16172256]
18. Schroeder, Harry W and Cavacini, Lisa.. (2010) Structure and function of immunoglobulins.. The Journal of allergy and clinical immunology, [PMID:20176268]
19. McHeyzer-Williams, Michael; Okitsu, Shinji; Wang, Nathaniel and McHeyzer-Williams, Louise.. (2011) Molecular programming of B cell memory.. Nature reviews. Immunology, (9): [PMID:22158414]
20. Joulia, Régis R and 6 more authors.. (2015) Mast cells form antibody-dependent degranulatory synapse for dedicated secretion and defence.. Nature communications, (28): [PMID:25629393]

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Ligelizumab (anti-IgE), 免疫球蛋白重常数ε抗体

库存信息

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库存信息

库存信息

基本信息

产品属性

图片

关联靶点（人）

作用机制

安全和危险性（GHS）

质量标准

质检证书（CoA,COO,BSE/TSE 和分析图谱)

可替换产品

参考文献

溶液计算器

摩尔浓度计算器

稀释计算器

复溶计算器

Ligelizumab (anti-IgE), 免疫球蛋白重常数ε抗体

库存信息

库存信息

库存信息

库存信息

基本信息

产品属性

图片

关联靶点（人）

作用机制

安全和危险性（GHS）

质量标准

质检证书（CoA,COO,BSE/TSE 和分析图谱)

相关产品

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参考文献

溶液计算器

摩尔浓度计算器

稀释计算器

复溶计算器