Lenzilumab (anti-GM-CSF), 粒细胞-巨噬细胞集落刺激因子抑制剂

    应用:
  • Animal Model
  • ELISA
  • Flow Cytometry
  • Functional Assay
功能和特点
  • 宿主种属: 人(Human)
  • 种属反应性: 人(Human)
  • 亚型: Human IgG1
  • 偶联: Unconjugated
有货

库存信息

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库存信息

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库存信息

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库存信息

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货号 (SKU) 包装规格 是否现货 价格 数量
Ab175576-100μg
100μg 现货 Stock Image
Ab175576-1mg
1mg 现货 Stock Image
Ab175576-5mg
5mg 现货 Stock Image
Ab175576-10mg
10mg 期货 Stock Image

基本信息

产品名称 Lenzilumab (anti-GM-CSF), 粒细胞-巨噬细胞集落刺激因子抑制剂
别名 仑兹鲁单抗 | 伦齐鲁单抗(抗基因重组坏死因子)
英文别名 Colony stimulating factor 2 (granulocyte-macrophage) antibody | Colony Stimulating Factor 2 antibody | Colony stimulating factor antibody | Colony-stimulating factor antibody | CSF 2 antibody | CSF antibody | CSF2 antibody | CSF2_HUMAN antibody | GM-CSF a
规格或纯度 无载体, 重组, ExactAb™, 低内毒素, 无叠氮钠, 已验证, 无动物源, ≥95%(SDS-PAGE&SEC-HPLC), 见COA
宿主种属 人(Human)
特异性 CSF2
种属反应性 人(Human)
偶联 Unconjugated
作用类型 抑制剂
作用机制 粒细胞-巨噬细胞集落刺激因子抑制剂

产品属性

克隆类型 重组抗体
Format Whole IgG
亚型 Human IgG1
轻链亚型 kappa
SDS-PAGE 25.9 kDa (Light Chain) & 50.1 kDa (Heavy Chain), under reducing conditions; 163.9 kDa, under non-reducing conditions.
纯化方法 Protein A purified
纯度 >95%
物理外观 Liquid
储存缓冲液 Supplied as a 0.22μm filtered solution in 100mM Pro-Ac, 20mM Arg, pH 5.0
防腐剂 No
浓度 见COA
储存温度 -80℃储存,避免反复冻融
运输条件 超低温冰袋运输
稳定性与储存 在 -80℃ 下保存 24 个月。收货后建议分装。避免冷冻/解冻循环。
CAS编号和信息 1229575-09-0
分子类型 抗体

图片

Lenzilumab (anti-GM-CSF) (Ab175576) - ELISA
Immobilized Recombinant Human GM-CSF Protein (rp146523) at 0.3 μg/mL can bind Lenzilumab (anti-GM-CSF) (Ab175576) with the EC₅₀ of 37.91 ng/mL.

Lenzilumab (anti-GM-CSF) (Ab175576) - SEC
The purity of Lenzilumab (anti-GM-CSF) (Ab175576) is more than 95% verified by HPLC.

关联靶点(人)

CSF2 Tbio 粒细胞巨噬细胞集落刺激因子(Granulocyte-macrophage colony-stimulating factor) (0 活性数据)
活性类型 活性值-log(M) 作用机制 期刊 参考文献(PubMed IDs)

作用机制

作用机制 Action Type target ID Target Name Target Type Target Organism Binding Site Name 参考文献

安全和危险性(GHS)

质量标准

质检证书(CoA,COO,BSE/TSE 和分析图谱)

C of A & Other Certificates(BSE/TSE, COO):
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找到6个结果

批号(Lot Number) 证书类型 日期 货号
ZJ24F1013220 分析证书 24-11-01 Ab175576
ZJ24F1013221 分析证书 24-11-01 Ab175576
ZJ24F1013219 分析证书 24-11-01 Ab175576
ZJ24F0303926 分析证书 24-03-29 Ab175576
ZJ24F0303925 分析证书 24-03-29 Ab175576
ZJ24F0303927 分析证书 24-03-29 Ab175576

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参考文献

1. Padron E, Painter JS, Kunigal S, Mailloux AW, McGraw K, McDaniel JM, Kim E, Bebbington C, Baer M, Yarranton G et al..  (2013)  GM-CSF-dependent pSTAT5 sensitivity is a feature with therapeutic potential in chronic myelomonocytic leukemia..  Blood,  121  (25): (5068-77).  [PMID:23632888]
2. Hamilton JA.  (2015)  GM-CSF as a target in inflammatory/autoimmune disease: current evidence and future therapeutic potential..  Expert Rev Clin Immunol,  11  (4): (457-65).  [PMID:25748625]
3. Walter, M R MR and 5 more authors..  (1992)  Three-dimensional structure of recombinant human granulocyte-macrophage colony-stimulating factor..  Journal of molecular biology,  (20): [PMID:1569568]
4. Kaushansky, K K, Lopez, J A JA and Brown, C B CB..  (1992)  Role of carbohydrate modification in the production and secretion of human granulocyte macrophage colony-stimulating factor in genetically engineered and normal mesenchymal cells..  Biochemistry,  (18): [PMID:1737041]
5. Diederichs, K K, Boone, T T and Karplus, P A PA..  (1991)  Novel fold and putative receptor binding site of granulocyte-macrophage colony-stimulating factor..  Science (New York, N.Y.),  (20): [PMID:1837174]
6. Kaushansky, K K and 5 more authors..  (1986)  Genomic cloning, characterization, and multilineage growth-promoting activity of human granulocyte-macrophage colony-stimulating factor..  Proceedings of the National Academy of Sciences of the United States of America,  [PMID:3486413]
7. Miyatake, S S, Otsuka, T T, Yokota, T T, Lee, F F and Arai, K K..  (1985)  Structure of the chromosomal gene for granulocyte-macrophage colony stimulating factor: comparison of the mouse and human genes..  The EMBO journal,  [PMID:3876930]
8. Cantrell, M A MA and 9 more authors..  (1985)  Cloning, sequence, and expression of a human granulocyte/macrophage colony-stimulating factor..  Proceedings of the National Academy of Sciences of the United States of America,  [PMID:3898082]
9. Wong, G G GG and 9 more authors..  (1985)  Human GM-CSF: molecular cloning of the complementary DNA and purification of the natural and recombinant proteins..  Science (New York, N.Y.),  (17): [PMID:3923623]
10. Lee, F F and 7 more authors..  (1985)  Isolation of cDNA for a human granulocyte-macrophage colony-stimulating factor by functional expression in mammalian cells..  Proceedings of the National Academy of Sciences of the United States of America,  [PMID:3925454]
11. Hansen, Guido G and 12 more authors..  (2008)  The structure of the GM-CSF receptor complex reveals a distinct mode of cytokine receptor activation..  Cell,  (8): [PMID:18692472]

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