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Lenzilumab (anti-GM-CSF) (Ab175576) - ELISA
Immobilized Recombinant Human GM-CSF Protein (rp146523) at 0.3 μg/mL can bind Lenzilumab (anti-GM-CSF) (Ab175576) with the EC₅₀ of 37.91 ng/mL.
| 货号 (SKU) | 包装规格 | 是否现货 | 价格 | 数量 |
|---|---|---|---|---|
| Ab175576-100μg |
100μg |
现货 ![]() |
| |
| Ab175576-1mg |
1mg |
现货 ![]() |
| |
| Ab175576-5mg |
5mg |
现货 ![]() |
| |
| Ab175576-10mg |
10mg |
期货 ![]() |
|
| 产品名称 | Lenzilumab (anti-GM-CSF), 粒细胞-巨噬细胞集落刺激因子抑制剂 |
|---|---|
| 别名 | 仑兹鲁单抗 | 伦齐鲁单抗(抗基因重组坏死因子) |
| 英文别名 | Colony stimulating factor 2 (granulocyte-macrophage) antibody | Colony Stimulating Factor 2 antibody | Colony stimulating factor antibody | Colony-stimulating factor antibody | CSF 2 antibody | CSF antibody | CSF2 antibody | CSF2_HUMAN antibody | GM-CSF a |
| 规格或纯度 | 无载体, 重组, ExactAb™, 低内毒素, 无叠氮钠, 已验证, 无动物源, ≥95%(SDS-PAGE&SEC-HPLC), 见COA |
| 宿主种属 | 人(Human) |
| 特异性 | CSF2 |
| 种属反应性 | 人(Human) |
| 偶联 | Unconjugated |
| 作用类型 | 抑制剂 |
| 作用机制 | 粒细胞-巨噬细胞集落刺激因子抑制剂 |
| 克隆类型 | 重组抗体 |
|---|---|
| Format | Whole IgG |
| 亚型 | Human IgG1 |
| 轻链亚型 | kappa |
| SDS-PAGE | 25.9 kDa (Light Chain) & 50.1 kDa (Heavy Chain), under reducing conditions; 163.9 kDa, under non-reducing conditions. |
| 纯化方法 | Protein A purified |
| 纯度 | >95% |
| 物理外观 | Liquid |
| 储存缓冲液 | Supplied as a 0.22μm filtered solution in 100mM Pro-Ac, 20mM Arg, pH 5.0 |
| 防腐剂 | No |
| 浓度 | 见COA |
| 储存温度 | -80℃储存,避免反复冻融 |
| 运输条件 | 超低温冰袋运输 |
| 稳定性与储存 | 在 -80℃ 下保存 24 个月。收货后建议分装。避免冷冻/解冻循环。 |
| CAS编号和信息 | 1229575-09-0 |
| 分子类型 | 抗体 |
Lenzilumab (anti-GM-CSF) (Ab175576) - ELISA
Immobilized Recombinant Human GM-CSF Protein (rp146523) at 0.3 μg/mL can bind Lenzilumab (anti-GM-CSF) (Ab175576) with the EC₅₀ of 37.91 ng/mL.
Lenzilumab (anti-GM-CSF) (Ab175576) - SEC
The purity of Lenzilumab (anti-GM-CSF) (Ab175576) is more than 95% verified by HPLC.
| 作用机制 | Action Type | target ID | Target Name | Target Type | Target Organism | Binding Site Name | 参考文献 |
|---|
通过匹配包装上的批号来查找并下载产品的 COA,每批产品都进行了严格的验证,您可放心使用!
| 批号(Lot Number) | 证书类型 | 日期 | 货号 |
|---|---|---|---|
| 分析证书 | 24-11-01 | Ab175576 | |
| 分析证书 | 24-11-01 | Ab175576 | |
| 分析证书 | 24-11-01 | Ab175576 | |
| 分析证书 | 24-03-29 | Ab175576 | |
| 分析证书 | 24-03-29 | Ab175576 | |
| 分析证书 | 24-03-29 | Ab175576 |
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| 1. Padron E, Painter JS, Kunigal S, Mailloux AW, McGraw K, McDaniel JM, Kim E, Bebbington C, Baer M, Yarranton G et al.. (2013) GM-CSF-dependent pSTAT5 sensitivity is a feature with therapeutic potential in chronic myelomonocytic leukemia.. Blood, 121 (25): (5068-77). [PMID:23632888] |
| 2. Hamilton JA. (2015) GM-CSF as a target in inflammatory/autoimmune disease: current evidence and future therapeutic potential.. Expert Rev Clin Immunol, 11 (4): (457-65). [PMID:25748625] |
| 3. Walter, M R MR and 5 more authors.. (1992) Three-dimensional structure of recombinant human granulocyte-macrophage colony-stimulating factor.. Journal of molecular biology, (20): [PMID:1569568] |
| 4. Kaushansky, K K, Lopez, J A JA and Brown, C B CB.. (1992) Role of carbohydrate modification in the production and secretion of human granulocyte macrophage colony-stimulating factor in genetically engineered and normal mesenchymal cells.. Biochemistry, (18): [PMID:1737041] |
| 5. Diederichs, K K, Boone, T T and Karplus, P A PA.. (1991) Novel fold and putative receptor binding site of granulocyte-macrophage colony-stimulating factor.. Science (New York, N.Y.), (20): [PMID:1837174] |
| 6. Kaushansky, K K and 5 more authors.. (1986) Genomic cloning, characterization, and multilineage growth-promoting activity of human granulocyte-macrophage colony-stimulating factor.. Proceedings of the National Academy of Sciences of the United States of America, [PMID:3486413] |
| 7. Miyatake, S S, Otsuka, T T, Yokota, T T, Lee, F F and Arai, K K.. (1985) Structure of the chromosomal gene for granulocyte-macrophage colony stimulating factor: comparison of the mouse and human genes.. The EMBO journal, [PMID:3876930] |
| 8. Cantrell, M A MA and 9 more authors.. (1985) Cloning, sequence, and expression of a human granulocyte/macrophage colony-stimulating factor.. Proceedings of the National Academy of Sciences of the United States of America, [PMID:3898082] |
| 9. Wong, G G GG and 9 more authors.. (1985) Human GM-CSF: molecular cloning of the complementary DNA and purification of the natural and recombinant proteins.. Science (New York, N.Y.), (17): [PMID:3923623] |
| 10. Lee, F F and 7 more authors.. (1985) Isolation of cDNA for a human granulocyte-macrophage colony-stimulating factor by functional expression in mammalian cells.. Proceedings of the National Academy of Sciences of the United States of America, [PMID:3925454] |
| 11. Hansen, Guido G and 12 more authors.. (2008) The structure of the GM-CSF receptor complex reveals a distinct mode of cytokine receptor activation.. Cell, (8): [PMID:18692472] |