基本信息

产品名称	Lecanemab (anti-Amyloid Beta), Beta 淀粉样蛋白 A4 蛋白抑制剂
别名	仑卡奈单抗 \| Lecanemab(抗淀粉样蛋白β)
英文别名	A4_HUMAN antibody \| AAA antibody \| ABETA antibody \| ABPP antibody \| AD1 antibody \| AICD-50 antibody \| AICD-57 antibody \| AICD-59 antibody \| AID(50) antibody \| AID(57) antibody \| AID(59) antibody \| Alzheimer disease amyloid protein antibody \| amyloid beta
规格或纯度	无载体, 重组, ExactAb™, 低内毒素, 无叠氮钠, 已验证, 无动物源, ≥95%(SDS-PAGE&SEC-HPLC), 见COA
宿主种属	人(Human)
特异性	APP
种属反应性	人(Human)
偶联	Unconjugated
作用类型	抑制剂
作用机制	Beta 淀粉样蛋白 A4 蛋白抑制剂

产品属性

克隆类型	重组抗体
Format	Whole IgG
亚型	Human IgG1
轻链亚型	kappa
SDS-PAGE	25.7 kDa (Light Chain) & 50.8 kDa (Heavy Chain), under reducing conditions; 216.7 kDa, under non-reducing conditions.
纯化方法	Protein A purified
纯度	>95%
物理外观	Liquid
储存缓冲液	Supplied as a 0.22μm filtered solution in 100mM Pro-Ac, 20mM Arg, pH 5.0
防腐剂	No
浓度	见COA
储存温度	-80℃储存,避免反复冻融
运输条件	超低温冰袋运输
稳定性与储存	在 -80℃ 下保存 24 个月。收货后建议分装。避免冷冻/解冻循环。
CAS编号和信息	1260393-98-3
分子类型	抗体

图片

Flow Cytometry: Lecanemab (anti-Amyloid Beta) (Ab175575)

Lecanemab (anti-Amyloid Beta) (Ab175575) - Flow Cytometry
Flow Cytometry analysis of HUVEC cells labelling Amyloid Beta (red) with Lecanemab (anti-Amyloid Beta) (Ab175575). Goat Anti-Human IgG (PE) (Ab175838) at a dilution of 1/1000 was used as the secondary antibody. Blue - Isotype control, human IgG (Ab170213). Black - Unlabelled control, cells without incubation with primary antibody.

ELISA: Lecanemab (anti-Amyloid Beta) (Ab175575)

Lecanemab (anti-Amyloid Beta) (Ab175575) - ELISA
Immobilized hu-Amyloid β-Peptide (1-40) at 2.0 μg/mL can bind Lecanemab (anti-Amyloid Beta) (Ab175575) with the EC₅₀ of 220.6 ng/mL.

SEC: Lecanemab (anti-Amyloid Beta) (Ab175575)

Lecanemab (anti-Amyloid Beta) (Ab175575) - SEC
The purity of Lecanemab (anti-Amyloid Beta) (Ab175575) is more than 95% verified by HPLC.

关联靶点（人）

APP Tclin 淀粉样β蛋白A4(Amyloid-beta A4 protein) (0 活性数据)

点击查看靶蛋白信息： APP

活性类型	活性值-log(M)	作用机制	期刊	参考文献(PubMed IDs)

作用机制

作用机制	Action Type	target ID	Target Name	Target Type	Target Organism	Binding Site Name	参考文献

安全和危险性（GHS）

SDS英文版

质量标准

质量标准

质检证书（CoA,COO,BSE/TSE 和分析图谱)

C of A & Other Certificates(BSE/TSE, COO):

输入批号以搜索分析图谱:

通过匹配包装上的批号来查找并下载产品的 COA，每批产品都进行了严格的验证，您可放心使用！

找到5个结果

批号(Lot Number)	证书类型	日期	货号
ZJ25F0117198	分析证书	25-01-17	Ab175575
ZJ25F0117197	分析证书	25-01-17	Ab175575
ZJ24F0303924	分析证书	24-03-29	Ab175575
ZJ24F0303923	分析证书	24-03-29	Ab175575
ZJ24F0303922	分析证书	24-03-29	Ab175575

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参考文献

1. Tucker S, Möller C, Tegerstedt K, Lord A, Laudon H, Sjödahl J, Söderberg L, Spens E, Sahlin C, Waara ER et al.. (2015) The murine version of BAN2401 (mAb158) selectively reduces amyloid-β protofibrils in brain and cerebrospinal fluid of tg-ArcSwe mice.. J Alzheimers Dis, 43 (2): (575-88). [PMID:25096615]
2. Söllvander S, Nikitidou E, Gallasch L, Zyśk M, Söderberg L, Sehlin D, Lannfelt L, Erlandsson A. (2018) The Aβ protofibril selective antibody mAb158 prevents accumulation of Aβ in astrocytes and rescues neurons from Aβ-induced cell death.. J Neuroinflammation, 15 (1): (98). [PMID:29592816]
3. Lee CW, Zhuang ZP, Kung MP, Plössl K, Skovronsky D, Gur T, Hou C, Trojanowski JQ, Lee VM, Kung HF.. (2001) Isomerization of (Z,Z) to (E,E)1-bromo-2,5-bis-(3-hydroxycarbonyl-4-hydroxy)styrylbenzene in strong base: probes for amyloid plaques in the brain.. J Med Chem, 44 (14): (2270-2275). [PMID:11428920] [10.1021/jm010161t]
4. Yazawa H, Yu ZX, Takeda, Le Y, Gong W, Ferrans VJ, Oppenheim JJ, Li CC, Wang JM. (2001) Beta amyloid peptide (Abeta42) is internalized via the G-protein-coupled receptor FPRL1 and forms fibrillar aggregates in macrophages.. FASEB J, 15 (13): (2454-62). [PMID:11689470]
5. Zha Z, Choi SR, Ploessl K, Lieberman BP, Qu W, Hefti F, Mintun M, Skovronsky D, Kung HF. (2011) Multidentate (18)F-polypegylated styrylpyridines as imaging agents for Aβ plaques in cerebral amyloid angiopathy (CAA).. J Med Chem, 54 (23): (8085-98). [PMID:22011144]
6. Choi SR, Golding G, Zhuang Z, Zhang W, Lim N, Hefti F, Benedum TE, Kilbourn MR, Skovronsky D, Kung HF. (2009) Preclinical properties of 18F-AV-45: a PET agent for Abeta plaques in the brain.. J Nucl Med, 50 (11): (1887-94). [PMID:19837759]
7. Kang J, Lemaire HG, Unterbeck A, Salbaum JM, Masters CL, Grzeschik KH, Multhaup G, Beyreuther K, Müller-Hill B. (1987) The precursor of Alzheimer's disease amyloid A4 protein resembles a cell-surface receptor.. Nature, 325 (6106): (733-6). [PMID:2881207]
8. Jiang XY, Chen TK, Zhou JT, He SY, Yang HY, Chen Y, Qu W, Feng F, Sun HP. (2018) Dual GSK-3β/AChE Inhibitors as a New Strategy for Multitargeting Anti-Alzheimer's Disease Drug Discovery.. ACS Med Chem Lett, 9 (3): (171-176). [PMID:29541355]
9. Nelson KM, Dahlin JL, Bisson J, Graham J, Pauli GF, Walters MA. (2017) The Essential Medicinal Chemistry of Curcumin.. J Med Chem, 60 (5): (1620-1637). [PMID:28074653]
10. Rajesh Chandra,Shunichi Oya,Mei-Ping Kung,Catherine Hou,Lee-Way Jin,Hank F Kung. (2007-04-24) New diphenylacetylenes as probes for positron emission tomographic imaging of amyloid plaques.. Journal of medicinal chemistry, 50 ((10)): (2415-2423). [PMID:17447752]
11. Craig B Stevens,James M Hanna,Robin K Lammi. (2013-02-14) Synthesis of tetrahydroxybiphenyls and tetrahydroxyterphenyls and their evaluation as amyloid-β aggregation inhibitors.. Bioorganic & medicinal chemistry letters, 23 ((6)): (1703-1706). [PMID:23403086]
12. Ryuto Kino,Takushi Araya,Tadamasa Arai,Youhei Sohma,Motomu Kanai. (2015-06-06) Covalent modifier-type aggregation inhibitor of amyloid-β based on a cyclo-KLVFF motif.. Bioorganic & medicinal chemistry letters, 25 ((15)): (2972-2975). [PMID:26045033]
13. Zhang W, Oya S, Kung MP, Hou C, Maier DL, Kung HF.. (2005) F-18 stilbenes as PET imaging agents for detecting beta-amyloid plaques in the brain.. J Med Chem, 48 (19): (5980-5988). [PMID:16162001] [10.1021/jm050166g]
14. Ono M, Kawashima H, Nonaka A, Kawai T, Haratake M, Mori H, Kung MP, Kung HF, Saji H, Nakayama M.. (2006) Novel benzofuran derivatives for PET imaging of beta-amyloid plaques in Alzheimer's disease brains.. J Med Chem, 49 (9): (2725-2730). [PMID:16640332] [10.1021/jm051176k]
15. Ono M, Yoshida N, Ishibashi K, Haratake M, Arano Y, Mori H, Nakayama M.. (2005) Radioiodinated flavones for in vivo imaging of beta-amyloid plaques in the brain.. J Med Chem, 48 (23): (7253-7260). [PMID:16279784] [10.1021/jm050635e]
16. Wu C, Wei J, Gao K, Wang Y.. (2007) Dibenzothiazoles as novel amyloid-imaging agents.. Bioorg Med Chem, 15 (7): (2789-2796). [PMID:17293116] [10.1016/j.bmc.2006.11.022]
17. Bolognesi ML, Banzi R, Bartolini M, Cavalli A, Tarozzi A, Andrisano V, Minarini A, Rosini M, Tumiatti V, Bergamini C, Fato R, Lenaz G, Hrelia P, Cattaneo A, Recanatini M, Melchiorre C.. (2007) Novel class of quinone-bearing polyamines as multi-target-directed ligands to combat Alzheimer's disease.. J Med Chem, 50 (20): (4882-4897). [PMID:17850125] [10.1021/jm070559a]
18. Serdons K, Verduyckt T, Vanderghinste D, Cleynhens J, Borghgraef P, Vermaelen P, Terwinghe C, Van Leuven F, Van Laere K, Kung H, Bormans G, Verbruggen A.. (2009) Synthesis of 18F-labelled 2-(4'-fluorophenyl)-1,3-benzothiazole and evaluation as amyloid imaging agent in comparison with [11C]PIB.. Bioorg Med Chem Lett, 19 (3): (602-605). [PMID:19147351] [10.1016/j.bmcl.2008.12.069]
19. Serdons K, Verduyckt T, Vanderghinste D, Borghgraef P, Cleynhens J, Van Leuven F, Kung H, Bormans G, Verbruggen A.. (2009) 11C-labelled PIB analogues as potential tracer agents for in vivo imaging of amyloid beta in Alzheimer's disease.. Eur J Med Chem, 44 (4): (1415-1426). [PMID:18992967] [10.1016/j.ejmech.2008.09.038]
20. Ammirati MJ, Andrews KM, Boyer DD, Brodeur AM, Danley DE, Doran SD, Hulin B, Liu S, McPherson RK, Orena SJ, Parker JC, Polivkova J, Qiu X, Soglia CB, Treadway JL, VanVolkenburg MA, Wilder DC, Piotrowski DW.. (2009) (3,3-Difluoro-pyrrolidin-1-yl)-[(2S,4S)-(4-(4-pyrimidin-2-yl-piperazin-1-yl)-pyrrolidin-2-yl]-methanone: a potent, selective, orally active dipeptidyl peptidase IV inhibitor.. Bioorg Med Chem Lett, 19 (7): (1991-1995). [PMID:19275964] [10.1016/j.bmcl.2009.02.041]
21. Kung HF, Choi SR, Qu W, Zhang W, Skovronsky D.. (2010) 18F stilbenes and styrylpyridines for PET imaging of A beta plaques in Alzheimer's disease: a miniperspective.. J Med Chem, 53 (3): (933-941). [PMID:19845387] [10.1021/jm901039z]
22. Nowak P, Cole DC, Aulabaugh A, Bard J, Chopra R, Cowling R, Fan KY, Hu B, Jacobsen S, Jani M, Jin G, Lo MC, Malamas MS, Manas ES, Narasimhan R, Reinhart P, Robichaud AJ, Stock JR, Subrath J, Svenson K, Turner J, Wagner E, Zhou P, Ellingboe JW.. (2010) Discovery and initial optimization of 5,5'-disubstituted aminohydantoins as potent beta-secretase (BACE1) inhibitors.. Bioorg Med Chem Lett, 20 (2): (632-635). [PMID:19959359] [10.1016/j.bmcl.2009.11.052]
23. Malamas MS, Barnes K, Hui Y, Johnson M, Lovering F, Condon J, Fobare W, Solvibile W, Turner J, Hu Y, Manas ES, Fan K, Olland A, Chopra R, Bard J, Pangalos MN, Reinhart P, Robichaud AJ.. (2010) Novel pyrrolyl 2-aminopyridines as potent and selective human beta-secretase (BACE1) inhibitors.. Bioorg Med Chem Lett, 20 (7): (2068-2073). [PMID:20223661] [10.1016/j.bmcl.2010.02.075]
24. Flaherty DP, Kiyota T, Dong Y, Ikezu T, Vennerstrom JL.. (2010) Phenolic bis-styrylbenzenes as β-amyloid binding ligands and free radical scavengers.. J Med Chem, 53 (22): (7992-7999). [PMID:21038854] [10.1021/jm1006929]
25. Ono M, Watanabe H, Watanabe R, Haratake M, Nakayama M, Saji H.. (2011) Diphenylpropynone derivatives as probes for imaging β-amyloid plaques in Alzheimer's brains.. Bioorg Med Chem Lett, 21 (1): (117-120). [PMID:21145738] [10.1016/j.bmcl.2010.11.058]
26. Yousefi BH, Manook A, Drzezga A, von Reutern B, Schwaiger M, Wester HJ, Henriksen G.. (2011) Synthesis and evaluation of 11C-labeled imidazo[2,1-b]benzothiazoles (IBTs) as PET tracers for imaging β-amyloid plaques in Alzheimer's disease.. J Med Chem, 54 (4): (949-956). [PMID:21275403] [10.1021/jm101129a]
27. Ono M, Cheng Y, Kimura H, Cui M, Kagawa S, Nishii R, Saji H.. (2011) Novel 18F-labeled benzofuran derivatives with improved properties for positron emission tomography (PET) imaging of β-amyloid plaques in Alzheimer's brains.. J Med Chem, 54 (8): (2971-2979). [PMID:21428407] [10.1021/jm200057u]
28. Cui M, Ono M, Kimura H, Liu B, Saji H.. (2011) Novel quinoxaline derivatives for in vivo imaging of β-amyloid plaques in the brain.. Bioorg Med Chem Lett, 21 (14): (4193-4196). [PMID:21684159] [10.1016/j.bmcl.2011.05.079]
29. Yousefi BH, Drzezga A, von Reutern B, Manook A, Schwaiger M, Wester HJ, Henriksen G.. (2011) A Novel (18)F-Labeled Imidazo[2,1-b]benzothiazole (IBT) for High-Contrast PET Imaging of β-Amyloid Plaques.. ACS Med Chem Lett, 2 (9): (673-677). [PMID:24900362] [10.1021/ml200123w]
30. Park YD, Park JH, Hur MG, Kim SW, Min JJ, Park SH, Yoo YJ, Yoon YJ, Yang SD.. (2012) Fluorescent 2-styrylpyridazin-3(2H)-one derivatives as probes targeting amyloid-beta plaques in Alzheimer's disease.. Bioorg Med Chem Lett, 22 (12): (4106-4110). [PMID:22578456] [10.1016/j.bmcl.2012.04.068]
31. Matsumura K, Ono M, Kimura H, Ueda M, Nakamoto Y, Togashi K, Okamoto Y, Ihara M, Takahashi R, Saji H.. (2012) (18)F-labeled phenyldiazenyl benzothiazole for in vivo imaging of neurofibrillary tangles in Alzheimer's disease brains.. ACS Med Chem Lett, 3 (1): (58-62). [PMID:24900371] [10.1021/ml200230e]
32. Novick PA, Lopes DH, Branson KM, Esteras-Chopo A, Graef IA, Bitan G, Pande VS.. (2012) Design of β-amyloid aggregation inhibitors from a predicted structural motif.. J Med Chem, 55 (7): (3002-3010). [PMID:22420626] [10.1021/jm201332p]
33. Watanabe H, Ono M, Kimura H, Matsumura K, Yoshimura M, Okamoto Y, Ihara M, Takahashi R, Saji H.. (2012) Synthesis and biological evaluation of novel oxindole derivatives for imaging neurofibrillary tangles in Alzheimer's disease.. Bioorg Med Chem Lett, 22 (17): (5700-5703). [PMID:22832319] [10.1016/j.bmcl.2012.06.086]
34. Rizzo S, Tarozzi A, Bartolini M, Da Costa G, Bisi A, Gobbi S, Belluti F, Ligresti A, Allarà M, Monti JP, Andrisano V, Di Marzo V, Hrelia P, Rampa A.. (2012) 2-Arylbenzofuran-based molecules as multipotent Alzheimer's disease modifying agents.. Eur J Med Chem, 58 (519-532). [PMID:23164658] [10.1016/j.ejmech.2012.10.045]
35. Gu J, Anumala UR, Lo Monte F, Kramer T, Heyny von Haußen R, Hölzer J, Goetschy-Meyer V, Mall G, Hilger I, Czech C, Schmidt B.. (2012) 2-Styrylindolium based fluorescent probes visualize neurofibrillary tangles in Alzheimer's disease.. Bioorg Med Chem Lett, 22 (24): (7667-7671). [PMID:23127889] [10.1016/j.bmcl.2012.09.109]
36. Jameson LP, Dzyuba SV.. (2013) Aza-BODIPY: improved synthesis and interaction with soluble Aβ1-42 oligomers.. Bioorg Med Chem Lett, 23 (6): (1732-1735). [PMID:23416005] [10.1016/j.bmcl.2013.01.065]
37. Bulic B, Pickhardt M, Mandelkow E.. (2013) Progress and developments in tau aggregation inhibitors for Alzheimer disease.. J Med Chem, 56 (11): (4135-4155). [PMID:23484434] [10.1021/jm3017317]
38. Byeon SR, Kim HV, Jeon M, Ahn YG, Kim MS, Kong JY, Kim HY, Kim YS, Kim DJ.. (2013) Therapeutic and pharmacokinetic characterizations of an anti-amyloidogenic bis-styrylbenzene derivative for Alzheimer's disease treatment.. Bioorg Med Chem Lett, 23 (11): (3467-3469). [PMID:23601707] [10.1016/j.bmcl.2013.02.104]
39. Matsumura K, Ono M, Yoshimura M, Kimura H, Watanabe H, Okamoto Y, Ihara M, Takahashi R, Saji H.. (2013) Synthesis and biological evaluation of novel styryl benzimidazole derivatives as probes for imaging of neurofibrillary tangles in Alzheimer's disease.. Bioorg Med Chem, 21 (11): (3356-3362). [PMID:23601814] [10.1016/j.bmc.2013.02.054]
40. Xie SS, Wang XB, Li JY, Yang L, Kong LY.. (2013) Design, synthesis and evaluation of novel tacrine-coumarin hybrids as multifunctional cholinesterase inhibitors against Alzheimer's disease.. Eur J Med Chem, 64 (540-553). [PMID:23685572] [10.1016/j.ejmech.2013.03.051]
41. Yoshimura M, Ono M, Matsumura K, Watanabe H, Kimura H, Cui M, Nakamoto Y, Togashi K, Okamoto Y, Ihara M, Takahashi R, Saji H.. (2013) Structure-Activity Relationships and in Vivo Evaluation of Quinoxaline Derivatives for PET Imaging of β-Amyloid Plaques.. ACS Med Chem Lett, 4 (7): (596-600). [PMID:24900717] [10.1021/ml4000707]
42. Keri RS, Quintanova C, Marques SM, Esteves AR, Cardoso SM, Santos MA.. (2013) Design, synthesis and neuroprotective evaluation of novel tacrine-benzothiazole hybrids as multi-targeted compounds against Alzheimer's disease.. Bioorg Med Chem, 21 (15): (4559-4569). [PMID:23768661] [10.1016/j.bmc.2013.05.028]
43. Chen YP, Zhang ZY, Li YP, Li D, Huang SL, Gu LQ, Xu J, Huang ZS.. (2013) Syntheses and evaluation of novel isoliquiritigenin derivatives as potential dual inhibitors for amyloid-beta aggregation and 5-lipoxygenase.. Eur J Med Chem, 66 (22-31). [PMID:23786711] [10.1016/j.ejmech.2013.05.015]
44. Huryn DM, Resnick LO, Wipf P.. (2013) Contributions of academic laboratories to the discovery and development of chemical biology tools.. J Med Chem, 56 (18): (7161-7176). [PMID:23672690] [10.1021/jm400132d]
45. Yu CW, Chang PT, Hsin LW, Chern JW.. (2013) Quinazolin-4-one derivatives as selective histone deacetylase-6 inhibitors for the treatment of Alzheimer's disease.. J Med Chem, 56 (17): (6775-6791). [PMID:23905680] [10.1021/jm400564j]
46. Madathil MM, Khdour OM, Jaruvangsanti J, Hecht SM.. (2013) A structurally simplified analogue of geldanamycin exhibits neuroprotective activity.. ACS Med Chem Lett, 4 (10): (953-957). [PMID:24900591] [10.1021/ml400207m]
47. Liu Y, Pukala TL, Musgrave IF, Williams DM, Dehle FC, Carver JA.. (2013) Gallic acid is the major component of grape seed extract that inhibits amyloid fibril formation.. Bioorg Med Chem Lett, 23 (23): (6336-6340). [PMID:24157371] [10.1016/j.bmcl.2013.09.071]
48. Luo W, Su YB, Hong C, Tian RG, Su LP, Wang YQ, Li Y, Yue JJ, Wang CJ.. (2013) Design, synthesis and evaluation of novel 4-dimethylamine flavonoid derivatives as potential multi-functional anti-Alzheimer agents.. Bioorg Med Chem, 21 (23): (7275-7282). [PMID:24148835] [10.1016/j.bmc.2013.09.061]
49. Gan C, Zhao Z, Nan DD, Yin B, Hu J.. (2014) Homoisoflavonoids as potential imaging agents for β-amyloid plaques in Alzheimer's disease.. Eur J Med Chem, 76 (125-131). [PMID:24583352] [10.1016/j.ejmech.2014.02.020]
50. Viayna E, Sola I, Bartolini M, De Simone A, Tapia-Rojas C, Serrano FG, Sabaté R, Juárez-Jiménez J, Pérez B, Luque FJ, Andrisano V, Clos MV, Inestrosa NC, Muñoz-Torrero D.. (2014) Synthesis and multitarget biological profiling of a novel family of rhein derivatives as disease-modifying anti-Alzheimer agents.. J Med Chem, 57 (6): (2549-2567). [PMID:24568372] [10.1021/jm401824w]
51. Wang H, Wang R, Lakshmana MK, Nefzi A.. (2014) Substituted dithiazole piperazine benzamides as novel amyloid beta peptide reducing agents.. Bioorg Med Chem Lett, 24 (18): (4384-4388). [PMID:25155386] [10.1016/j.bmcl.2014.08.022]
52. Brus B, Košak U, Turk S, Pišlar A, Coquelle N, Kos J, Stojan J, Colletier JP, Gobec S.. (2014) Discovery, biological evaluation, and crystal structure of a novel nanomolar selective butyrylcholinesterase inhibitor.. J Med Chem, 57 (19): (8167-8179). [PMID:25226236] [10.1021/jm501195e]
53. Lan JS, Xie SS, Li SY, Pan LF, Wang XB, Kong LY.. (2014) Design, synthesis and evaluation of novel tacrine-(β-carboline) hybrids as multifunctional agents for the treatment of Alzheimer's disease.. Bioorg Med Chem, 22 (21): (6089-6104). [PMID:25282654] [10.1016/j.bmc.2014.08.035]
54. Jesus AR, Dias C, Matos AM, de Almeida RF, Viana AS, Marcelo F, Ribeiro RT, Macedo MP, Airoldi C, Nicotra F, Martins A, Cabrita EJ, Jiménez-Barbero J, Rauter AP.. (2014) Exploiting the therapeutic potential of 8-β-d-glucopyranosylgenistein: synthesis, antidiabetic activity, and molecular interaction with islet amyloid polypeptide and amyloid β-peptide (1-42).. J Med Chem, 57 (22): (9463-9472). [PMID:25347820] [10.1021/jm501069h]
55. Sun Q, Peng DY, Yang SG, Zhu XL, Yang WC, Yang GF.. (2014) Syntheses of coumarin-tacrine hybrids as dual-site acetylcholinesterase inhibitors and their activity against butylcholinesterase, Aβ aggregation, and β-secretase.. Bioorg Med Chem, 22 (17): (4784-4791). [PMID:25088549] [10.1016/j.bmc.2014.06.057]
56. Huang M, Xie SS, Jiang N, Lan JS, Kong LY, Wang XB.. (2015) Multifunctional coumarin derivatives: monoamine oxidase B (MAO-B) inhibition, anti-β-amyloid (Aβ) aggregation and metal chelation properties against Alzheimer's disease.. Bioorg Med Chem Lett, 25 (3): (508-513). [PMID:25542589] [10.1016/j.bmcl.2014.12.034]
57. Digiacomo M, Chen Z, Wang S, Lapucci A, Macchia M, Yang X, Chu J, Han Y, Pi R, Rapposelli S.. (2015) Synthesis and pharmacological evaluation of multifunctional tacrine derivatives against several disease pathways of AD.. Bioorg Med Chem Lett, 25 (4): (807-810). [PMID:25597007] [10.1016/j.bmcl.2014.12.084]
58. Hamada Y, Miyamoto N, Kiso Y.. (2015) Novel β-amyloid aggregation inhibitors possessing a turn mimic.. Bioorg Med Chem Lett, 25 (7): (1572-1576). [PMID:25736996] [10.1016/j.bmcl.2015.02.016]
59. Liao S, Deng H, Huang S, Yang J, Wang S, Yin B, Zheng T, Zhang D, Liu J, Gao G, Ma J, Deng Z.. (2015) Design, synthesis and evaluation of novel 5,6,7-trimethoxyflavone-6-chlorotacrine hybrids as potential multifunctional agents for the treatment of Alzheimer's disease.. Bioorg Med Chem Lett, 25 (7): (1541-1545). [PMID:25724825] [10.1016/j.bmcl.2015.02.015]
60. Więckowska A, Więckowski K, Bajda M, Brus B, Sałat K, Czerwińska P, Gobec S, Filipek B, Malawska B.. (2015) Synthesis of new N-benzylpiperidine derivatives as cholinesterase inhibitors with β-amyloid anti-aggregation properties and beneficial effects on memory in vivo.. Bioorg Med Chem, 23 (10): (2445-2457). [PMID:25868744] [10.1016/j.bmc.2015.03.051]
61. Xie S, Chen J, Li X, Su T, Wang Y, Wang Z, Huang L, Li X.. (2015) Synthesis and evaluation of selegiline derivatives as monoamine oxidase inhibitor, antioxidant and metal chelator against Alzheimer's disease.. Bioorg Med Chem, 23 (13): (3722-3729). [PMID:25934229] [10.1016/j.bmc.2015.04.009]
62. Chu W, Zhou D, Gaba V, Liu J, Li S, Peng X, Xu J, Dhavale D, Bagchi DP, d'Avignon A, Shakerdge NB, Bacskai BJ, Tu Z, Kotzbauer PT, Mach RH.. (2015) Design, Synthesis, and Characterization of 3-(Benzylidene)indolin-2-one Derivatives as Ligands for α-Synuclein Fibrils.. J Med Chem, 58 (15): (6002-6017). [PMID:26177091] [10.1021/acs.jmedchem.5b00571]
63. Telpoukhovskaia MA, Cawthray JF, Rodríguez-Rodríguez C, Scott LE, Page BD, Patrick BO, Orvig C.. (2015) 3-Hydroxy-4-pyridinone derivatives designed for fluorescence studies to determine interaction with amyloid protein as well as cell permeability.. Bioorg Med Chem Lett, 25 (17): (3654-3657). [PMID:26141772] [10.1016/j.bmcl.2015.06.059]
64. Manral A, Saini V, Meena P, Tiwari M.. (2015) Multifunctional novel Diallyl disulfide (DADS) derivatives with β-amyloid-reducing, cholinergic, antioxidant and metal chelating properties for the treatment of Alzheimer's disease.. Bioorg Med Chem, 23 (19): (6389-6403). [PMID:26337018] [10.1016/j.bmc.2015.08.024]
65. Wang Z, Wang Y, Wang B, Li W, Huang L, Li X.. (2015) Design, Synthesis, and Evaluation of Orally Available Clioquinol-Moracin M Hybrids as Multitarget-Directed Ligands for Cognitive Improvement in a Rat Model of Neurodegeneration in Alzheimer's Disease.. J Med Chem, 58 (21): (8616-8637). [PMID:26473791] [10.1021/acs.jmedchem.5b01222]
66. Zha X, Lamba D, Zhang L, Lou Y, Xu C, Kang D, Chen L, Xu Y, Zhang L, De Simone A, Samez S, Pesaresi A, Stojan J, Lopez MG, Egea J, Andrisano V, Bartolini M.. (2016) Novel Tacrine-Benzofuran Hybrids as Potent Multitarget-Directed Ligands for the Treatment of Alzheimer's Disease: Design, Synthesis, Biological Evaluation, and X-ray Crystallography.. J Med Chem, 59 (1): (114-131). [PMID:26632651] [10.1021/acs.jmedchem.5b01119]
67. Sun ZQ, Tu LX, Zhuo FJ, Liu SX.. (2016) Design and discovery of Novel Thiazole acetamide derivatives as anticholinesterase agent for possible role in the management of Alzheimer's.. Bioorg Med Chem Lett, 26 (3): (747-750). [PMID:26783181] [10.1016/j.bmcl.2016.01.001]
68. Li L, Chen M, Jiang FC.. (2016) Design, synthesis, and evaluation of 2-piperidone derivatives for the inhibition of β-amyloid aggregation and inflammation mediated neurotoxicity.. Bioorg Med Chem, 24 (8): (1853-1865). [PMID:26972922] [10.1016/j.bmc.2016.03.010]
69. Li Y, Qiang X, Li Y, Yang X, Luo L, Xiao G, Cao Z, Tan Z, Deng Y.. (2016) Pterostilbene-O-acetamidoalkylbenzylamines derivatives as novel dual inhibitors of cholinesterase with anti-β-amyloid aggregation and antioxidant properties for the treatment of Alzheimer's disease.. Bioorg Med Chem Lett, 26 (8): (2035-2039). [PMID:26947607] [10.1016/j.bmcl.2016.02.079]
70. Li Y, Qiang X, Luo L, Li Y, Xiao G, Tan Z, Deng Y.. (2016) Synthesis and evaluation of 4-hydroxyl aurone derivatives as multifunctional agents for the treatment of Alzheimer's disease.. Bioorg Med Chem, 24 (10): (2342-2351). [PMID:27079124] [10.1016/j.bmc.2016.04.012]
71. Pan W, Hu K, Bai P, Yu L, Ma Q, Li T, Zhang X, Chen C, Peng K, Liu W, Sang Z.. (2016) Design, synthesis and evaluation of novel ferulic acid-memoquin hybrids as potential multifunctional agents for the treatment of Alzheimer's disease.. Bioorg Med Chem Lett, 26 (10): (2539-2543). [PMID:27072909] [10.1016/j.bmcl.2016.03.086]
72. Mishra CB, Manral A, Kumari S, Saini V, Tiwari M.. (2016) Design, synthesis and evaluation of novel indandione derivatives as multifunctional agents with cholinesterase inhibition, anti-β-amyloid aggregation, antioxidant and neuroprotection properties against Alzheimer's disease.. Bioorg Med Chem, 24 (16): (3829-3841). [PMID:27353888] [10.1016/j.bmc.2016.06.027]
73. Chakraborty S, Bandyopadhyay J, Chakraborty S, Basu S.. (2016) Multi-target screening mines hesperidin as a multi-potent inhibitor: Implication in Alzheimer's disease therapeutics.. Eur J Med Chem, 121 (810-822). [PMID:27068363] [10.1016/j.ejmech.2016.03.057]
74. Li X, Wang H, Lu Z, Zheng X, Ni W, Zhu J, Fu Y, Lian F, Zhang N, Li J, Zhang H, Mao F.. (2016) Development of Multifunctional Pyrimidinylthiourea Derivatives as Potential Anti-Alzheimer Agents.. J Med Chem, 59 (18): (8326-8344). [PMID:27552582] [10.1021/acs.jmedchem.6b00636]
75. Turner JP, Chastain SE, Park D, Moss MA, Servoss SL.. (2017) Modulating amyloid-β aggregation: The effects of peptoid side chain placement and chirality.. Bioorg Med Chem, 25 (1): (20-26). [PMID:27776890] [10.1016/j.bmc.2016.10.007]
76. Wang ZM, Cai P, Liu QH, Xu DQ, Yang XL, Wu JJ, Kong LY, Wang XB.. (2016) Rational modification of donepezil as multifunctional acetylcholinesterase inhibitors for the treatment of Alzheimer's disease.. Eur J Med Chem, 123 (282-297). [PMID:27484514] [10.1016/j.ejmech.2016.07.052]
77. Horton W, Sood A, Peerannawar S, Kugyela N, Kulkarni A, Tulsan R, Tran CD, Soule J, LeVine H, Török B, Török M.. (2017) Synthesis and application of β-carbolines as novel multi-functional anti-Alzheimer's disease agents.. Bioorg Med Chem Lett, 27 (2): (232-236). [PMID:27923619] [10.1016/j.bmcl.2016.11.067]
78. Košak U, Knez D, Coquelle N, Brus B, Pišlar A, Nachon F, Brazzolotto X, Kos J, Colletier JP, Gobec S.. (2017) N-Propargylpiperidines with naphthalene-2-carboxamide or naphthalene-2-sulfonamide moieties: Potential multifunctional anti-Alzheimer's agents.. Bioorg Med Chem, 25 (2): (633-645). [PMID:27908752] [10.1016/j.bmc.2016.11.032]
79. Li Y, Qiang X, Luo L, Yang X, Xiao G, Zheng Y, Cao Z, Sang Z, Su F, Deng Y.. (2017) Multitarget drug design strategy against Alzheimer's disease: Homoisoflavonoid Mannich base derivatives serve as acetylcholinesterase and monoamine oxidase B dual inhibitors with multifunctional properties.. Bioorg Med Chem, 25 (2): (714-726). [PMID:27923535] [10.1016/j.bmc.2016.11.048]
80. Xiao G, Li Y, Qiang X, Xu R, Zheng Y, Cao Z, Luo L, Yang X, Sang Z, Su F, Deng Y.. (2017) Design, synthesis and biological evaluation of 4'-aminochalcone-rivastigmine hybrids as multifunctional agents for the treatment of Alzheimer's disease.. Bioorg Med Chem, 25 (3): (1030-1041). [PMID:28011206] [10.1016/j.bmc.2016.12.013]
81. Jiaranaikulwanitch J, Tadtong S, Govitrapong P, Fokin VV, Vajragupta O.. (2017) Neuritogenic activity of bi-functional bis-tryptoline triazole.. Bioorg Med Chem, 25 (3): (1195-1201). [PMID:28043778] [10.1016/j.bmc.2016.12.027]
82. Panek D, Więckowska A, Wichur T, Bajda M, Godyń J, Jończyk J, Mika K, Janockova J, Soukup O, Knez D, Korabecny J, Gobec S, Malawska B.. (2017) Design, synthesis and biological evaluation of new phthalimide and saccharin derivatives with alicyclic amines targeting cholinesterases, beta-secretase and amyloid beta aggregation.. Eur J Med Chem, 125 (676-695). [PMID:27721153] [10.1016/j.ejmech.2016.09.078]
83. Mishra CB, Kumari S, Manral A, Prakash A, Saini V, Lynn AM, Tiwari M.. (2017) Design, synthesis, in-silico and biological evaluation of novel donepezil derivatives as multi-target-directed ligands for the treatment of Alzheimer's disease.. Eur J Med Chem, 125 (736-750). [PMID:27721157] [10.1016/j.ejmech.2016.09.057]
84. Luo L, Li Y, Qiang X, Cao Z, Xu R, Yang X, Xiao G, Song Q, Tan Z, Deng Y.. (2017) Multifunctional thioxanthone derivatives with acetylcholinesterase, monoamine oxidases and β-amyloid aggregation inhibitory activities as potential agents against Alzheimer's disease.. Bioorg Med Chem, 25 (6): (1997-2009). [PMID:28237559] [10.1016/j.bmc.2017.02.027]
85. Xu P, Zhang M, Sheng R, Ma Y.. (2017) Synthesis and biological evaluation of deferiprone-resveratrol hybrids as antioxidants, Aβ1-42 aggregation inhibitors and metal-chelating agents for Alzheimer's disease.. Eur J Med Chem, 127 (174-186). [PMID:28061347] [10.1016/j.ejmech.2016.12.045]
86. Li Y, Qiang X, Luo L, Yang X, Xiao G, Liu Q, Ai J, Tan Z, Deng Y.. (2017) Aurone Mannich base derivatives as promising multifunctional agents with acetylcholinesterase inhibition, anti-β-amyloid aggragation and neuroprotective properties for the treatment of Alzheimer's disease.. Eur J Med Chem, 126 (762-775). [PMID:27951485] [10.1016/j.ejmech.2016.12.009]
87. Qiang X, Li Y, Yang X, Luo L, Xu R, Zheng Y, Cao Z, Tan Z, Deng Y.. (2017) DL-3-n-butylphthalide-Edaravone hybrids as novel dual inhibitors of amyloid-β aggregation and monoamine oxidases with high antioxidant potency for Alzheimer's therapy.. Bioorg Med Chem Lett, 27 (4): (718-722). [PMID:28131710] [10.1016/j.bmcl.2017.01.050]
88. Sang Z, Pan W, Wang K, Ma Q, Yu L, Yang Y, Bai P, Leng C, Xu Q, Li X, Tan Z, Liu W.. (2017) Design, synthesis and evaluation of novel ferulic acid-O-alkylamine derivatives as potential multifunctional agents for the treatment of Alzheimer's disease.. Eur J Med Chem, 130 (379-392). [PMID:28279845] [10.1016/j.ejmech.2017.02.039]
89. Lan JS, Zhang T, Liu Y, Yang J, Xie SS, Liu J, Miao ZY, Ding Y.. (2017) Design, synthesis and biological activity of novel donepezil derivatives bearing N-benzyl pyridinium moiety as potent and dual binding site acetylcholinesterase inhibitors.. Eur J Med Chem, 133 (184-196). [PMID:28388521] [10.1016/j.ejmech.2017.02.045]
90. Wang Z, Hu J, Yang X, Feng X, Li X, Huang L, Chan ASC.. (2018) Design, Synthesis, and Evaluation of Orally Bioavailable Quinoline-Indole Derivatives as Innovative Multitarget-Directed Ligands: Promotion of Cell Proliferation in the Adult Murine Hippocampus for the Treatment of Alzheimer's Disease.. J Med Chem, 61 (5): (1871-1894). [PMID:29420891] [10.1021/acs.jmedchem.7b01417]
91. De Simone A, Bartolini M, Baschieri A, Apperley KYP, Chen HH, Guardigni M, Montanari S, Kobrlova T, Soukup O, Valgimigli L, Andrisano V, Keillor JW, Basso M, Milelli A.. (2017) Hydroxy-substituted trans-cinnamoyl derivatives as multifunctional tools in the context of Alzheimer's disease.. Eur J Med Chem, 139 (378-389). [PMID:28810189] [10.1016/j.ejmech.2017.07.058]
92. Pandolfi F, De Vita D, Bortolami M, Coluccia A, Di Santo R, Costi R, Andrisano V, Alabiso F, Bergamini C, Fato R, Bartolini M, Scipione L.. (2017) New pyridine derivatives as inhibitors of acetylcholinesterase and amyloid aggregation.. Eur J Med Chem, 141 (197-210). [PMID:29031067] [10.1016/j.ejmech.2017.09.022]
93. Nesi G, Chen Q, Sestito S, Digiacomo M, Yang X, Wang S, Pi R, Rapposelli S.. (2017) Nature-based molecules combined with rivastigmine: A symbiotic approach for the synthesis of new agents against Alzheimer's disease.. Eur J Med Chem, 141 (232-239). [PMID:29031070] [10.1016/j.ejmech.2017.10.006]
94. Jameel E, Meena P, Maqbool M, Kumar J, Ahmed W, Mumtazuddin S, Tiwari M, Hoda N, Jayaram B.. (2017) Rational design, synthesis and biological screening of triazine-triazolopyrimidine hybrids as multitarget anti-Alzheimer agents.. Eur J Med Chem, 136 (36-51). [PMID:28478343] [10.1016/j.ejmech.2017.04.064]
95. Xu YX, Wang H, Li XK, Dong SN, Liu WW, Gong Q, Wang TD, Tang Y, Zhu J, Li J, Zhang HY, Mao F.. (2018) Discovery of novel propargylamine-modified 4-aminoalkyl imidazole substituted pyrimidinylthiourea derivatives as multifunctional agents for the treatment of Alzheimer's disease.. Eur J Med Chem, 143 (33-47). [PMID:29172081] [10.1016/j.ejmech.2017.08.025]
96. Sun G, Wang J, Guo X, Lei M, Zhang Y, Wang X, Shen X, Hu L.. (2018) Design, synthesis and biological evaluation of LX2343 derivatives as neuroprotective agents for the treatment of Alzheimer's disease.. Eur J Med Chem, 145 (622-633). [PMID:29339255] [10.1016/j.ejmech.2017.12.080]
97. Czarnecka K, Chufarova N, Halczuk K, Maciejewska K, Girek M, Skibiński R, Jończyk J, Bajda M, Kabziński J, Majsterek I, Szymański P.. (2018) Tetrahydroacridine derivatives with dichloronicotinic acid moiety as attractive, multipotent agents for Alzheimer's disease treatment.. Eur J Med Chem, 145 (760-769). [PMID:29353726] [10.1016/j.ejmech.2018.01.014]
98. Jiang N, Huang Q, Liu J, Liang N, Li Q, Li Q, Xie SS.. (2018) Design, synthesis and biological evaluation of new coumarin-dithiocarbamate hybrids as multifunctional agents for the treatment of Alzheimer's disease.. Eur J Med Chem, 146 (287-298). [PMID:29407958] [10.1016/j.ejmech.2018.01.055]
99. Ghobadian R, Mahdavi M, Nadri H, Moradi A, Edraki N, Akbarzadeh T, Sharifzadeh M, Bukhari SNA, Amini M.. (2018) Novel tetrahydrocarbazole benzyl pyridine hybrids as potent and selective butryl cholinesterase inhibitors with neuroprotective and β-secretase inhibition activities.. Eur J Med Chem, 155 (49-60). [PMID:29857276] [10.1016/j.ejmech.2018.05.031]
100. Chioua M, Buzzi E, Moraleda I, Iriepa I, Maj M, Wnorowski A, Giovannini C, Tramarin A, Portali F, Ismaili L, López-Alvarado P, Bolognesi ML, Jóźwiak K, Menéndez JC, Marco-Contelles J, Bartolini M.. (2018) Tacripyrimidines, the first tacrine-dihydropyrimidine hybrids, as multi-target-directed ligands for Alzheimer's disease.. Eur J Med Chem, 155 (839-846). [PMID:29958119] [10.1016/j.ejmech.2018.06.044]
101. Martínez A, Zahran M, Gomez M, Cooper C, Guevara J, Ekengard E, Nordlander E, Alcendor R, Hambleton S.. (2018) Novel multi-target compounds in the quest for new chemotherapies against Alzheimer's disease: An experimental and theoretical study.. Bioorg Med Chem, 26 (17): (4823-4840). [PMID:30181028] [10.1016/j.bmc.2018.08.019]
102. Yang HL, Cai P, Liu QH, Yang XL, Fang SQ, Tang YW, Wang C, Wang XB, Kong LY.. (2017) Design, synthesis, and evaluation of salicyladimine derivatives as multitarget-directed ligands against Alzheimer's disease.. Bioorg Med Chem, 25 (21): (5917-5928). [PMID:28988627] [10.1016/j.bmc.2017.08.048]
103. Yang HL, Cai P, Liu QH, Yang XL, Li F, Wang J, Wu JJ, Wang XB, Kong LY.. (2017) Design, synthesis and evaluation of coumarin-pargyline hybrids as novel dual inhibitors of monoamine oxidases and amyloid-β aggregation for the treatment of Alzheimer's disease.. Eur J Med Chem, 138 (715-728). [PMID:28728104] [10.1016/j.ejmech.2017.07.008]
104. Lan JS, Ding Y, Liu Y, Kang P, Hou JW, Zhang XY, Xie SS, Zhang T.. (2017) Design, synthesis and biological evaluation of novel coumarin-N-benzyl pyridinium hybrids as multi-target agents for the treatment of Alzheimer's disease.. Eur J Med Chem, 139 (48-59). [PMID:28797883] [10.1016/j.ejmech.2017.07.055]
105. Ma F, Du H.. (2017) Novel deoxyvasicinone derivatives as potent multitarget-directed ligands for the treatment of Alzheimer's disease: Design, synthesis, and biological evaluation.. Eur J Med Chem, 140 (118-127). [PMID:28923380] [10.1016/j.ejmech.2017.09.008]
106. Li G, Hong G, Li X, Zhang Y, Xu Z, Mao L, Feng X, Liu T.. (2018) Synthesis and activity towards Alzheimer's disease in vitro: Tacrine, phenolic acid and ligustrazine hybrids.. Eur J Med Chem, 148 (238-254). [PMID:29466774] [10.1016/j.ejmech.2018.01.028]
107. Hiremathad A, Keri RS, Esteves AR, Cardoso SM, Chaves S, Santos MA.. (2018) Novel Tacrine-Hydroxyphenylbenzimidazole hybrids as potential multitarget drug candidates for Alzheimer's disease.. Eur J Med Chem, 148 (255-267). [PMID:29466775] [10.1016/j.ejmech.2018.02.023]
108. Xu R, Xiao G, Li Y, Liu H, Song Q, Zhang X, Yang Z, Zheng Y, Tan Z, Deng Y.. (2018) Multifunctional 5,6-dimethoxybenzo[d]isothiazol-3(2H)-one-N-alkylbenzylamine derivatives with acetylcholinesterase, monoamine oxidases and β-amyloid aggregation inhibitory activities as potential agents against Alzheimer's disease.. Bioorg Med Chem, 26 (8): (1885-1895). [PMID:29500132] [10.1016/j.bmc.2018.02.037]
109. Gay M, Carato P, Coevoet M, Renault N, Larchanché PE, Barczyk A, Yous S, Buée L, Sergeant N, Melnyk P.. (2018) New phenylaniline derivatives as modulators of amyloid protein precursor metabolism.. Bioorg Med Chem, 26 (8): (2151-2164). [PMID:29559198] [10.1016/j.bmc.2018.03.016]
110. Ghobadian R, Nadri H, Moradi A, Bukhari SNA, Mahdavi M, Asadi M, Akbarzadeh T, Khaleghzadeh-Ahangar H, Sharifzadeh M, Amini M.. (2018) Design, synthesis, and biological evaluation of selective and potent Carbazole-based butyrylcholinesterase inhibitors.. Bioorg Med Chem, 26 (17): (4952-4962). [PMID:30190181] [10.1016/j.bmc.2018.08.035]
111. Cai P, Fang SQ, Yang HL, Yang XL, Liu QH, Kong LY, Wang XB.. (2018) Donepezil-butylated hydroxytoluene (BHT) hybrids as Anti-Alzheimer's disease agents with cholinergic, antioxidant, and neuroprotective properties.. Eur J Med Chem, 157 (161-176). [PMID:30096650] [10.1016/j.ejmech.2018.08.005]
112. Pérez-Areales FJ, Turcu AL, Barniol-Xicota M, Pont C, Pivetta D, Espargaró A, Bartolini M, De Simone A, Andrisano V, Pérez B, Sabate R, Sureda FX, Vázquez S, Muñoz-Torrero D.. (2019) A novel class of multitarget anti-Alzheimer benzohomoadamantane‒chlorotacrine hybrids modulating cholinesterases and glutamate NMDA receptors.. Eur J Med Chem, 180 (613-626). [PMID:31351393] [10.1016/j.ejmech.2019.07.051]
113. McKinnell RM, Fatheree P, Choi SK, Gendron R, Jendza K, Olson Blair B, Budman J, Hill CM, Hegde LG, Yu C, McConn D, Hegde SS, Marquess DG, Klein U.. (2019) Discovery of TD-0212, an Orally Active Dual Pharmacology AT₁ Antagonist and Neprilysin Inhibitor (ARNI).. ACS Med Chem Lett, 10 (1): (86-91). [PMID:30655952] [10.1021/acsmedchemlett.8b00462]
114. Bai P, Wang K, Zhang P, Shi J, Cheng X, Zhang Q, Zheng C, Cheng Y, Yang J, Lu X, Sang Z.. (2019) Development of chalcone-O-alkylamine derivatives as multifunctional agents against Alzheimer's disease.. Eur J Med Chem, 183 (111737-111737). [PMID:31581002] [10.1016/j.ejmech.2019.111737]
115. Cong L, Dong X, Wang Y, Deng Y, Li B, Dai R.. (2019) On the role of synthesized hydroxylated chalcones as dual functional amyloid-β aggregation and ferroptosis inhibitors for potential treatment of Alzheimer's disease.. Eur J Med Chem, 166 (11-21). [PMID:30684867] [10.1016/j.ejmech.2019.01.039]
116. Tu Y, Wu C, Kang Y, Li Q, Zhu C, Li Y.. (2019) Bioactivity-guided identification of flavonoids with cholinesterase and β-amyloid peptide aggregation inhibitory effects from the seeds of Millettia pachycarpa.. Bioorg Med Chem Lett, 29 (10): (1194-1198). [PMID:30910460] [10.1016/j.bmcl.2019.03.024]
117. Unsal-Tan O, Tüylü Küçükkılınç T, Ayazgök B, Balkan A, Ozadali-Sari K.. (2019) Synthesis, molecular docking, and biological evaluation of novel 2-pyrazoline derivatives as multifunctional agents for the treatment of Alzheimer's disease.. Medchemcomm, 10 (6): (1018-1026). [PMID:31304000] [10.1039/C9MD00030E]
118. Zhang P, Xu S, Zhu Z, Xu J.. (2019) Multi-target design strategies for the improved treatment of Alzheimer's disease.. Eur J Med Chem, 176 (228-247). [PMID:31103902] [10.1016/j.ejmech.2019.05.020]
119. Sang Z, Wang K, Shi J, Liu W, Tan Z.. (2019) Design, synthesis, in-silico and biological evaluation of novel chalcone-O-carbamate derivatives as multifunctional agents for the treatment of Alzheimer's disease.. Eur J Med Chem, 178 (726-739). [PMID:31229875] [10.1016/j.ejmech.2019.06.026]
120. Sang Z, Wang K, Zhang P, Shi J, Liu W, Tan Z.. (2019) Design, synthesis, in-silico and biological evaluation of novel chalcone derivatives as multi-function agents for the treatment of Alzheimer's disease.. Eur J Med Chem, 180 (238-252). [PMID:31310916] [10.1016/j.ejmech.2019.07.021]
121. Liu Y, Jovcevski B, Pukala TL.. (2019) C-Phycocyanin from Spirulina Inhibits α-Synuclein and Amyloid-β Fibril Formation but Not Amorphous Aggregation.. J Nat Prod, 82 (1): (66-73). [PMID:30620188] [10.1021/acs.jnatprod.8b00610]
122. Scipioni M, Kay G, Megson IL, Kong Thoo Lin P.. (2019) Synthesis of novel vanillin derivatives: novel multi-targeted scaffold ligands against Alzheimer's disease.. Medchemcomm, 10 (5): (764-777). [PMID:31191867] [10.1039/C9MD00048H]
123. Chalupova K, Korabecny J, Bartolini M, Monti B, Lamba D, Caliandro R, Pesaresi A, Brazzolotto X, Gastellier AJ, Nachon F, Pejchal J, Jarosova M, Hepnarova V, Jun D, Hrabinova M, Dolezal R, Zdarova Karasova J, Mzik M, Kristofikova Z, Misik J, Muckova L, Jost P, Soukup O, Benkova M, Setnicka V, Habartova L, Chvojkova M, Kleteckova L, Vales K, Mezeiova E, Uliassi E, Valis M, Nepovimova E, Bolognesi ML, Kuca K.. (2019) Novel tacrine-tryptophan hybrids: Multi-target directed ligands as potential treatment for Alzheimer's disease.. Eur J Med Chem, 168 (491-514). [PMID:30851693] [10.1016/j.ejmech.2019.02.021]
124. Purgatorio R, de Candia M, Catto M, Carrieri A, Pisani L, De Palma A, Toma M, Ivanova OA, Voskressensky LG, Altomare CD.. (2019) Investigating 1,2,3,4,5,6-hexahydroazepino[4,3-b]indole as scaffold of butyrylcholinesterase-selective inhibitors with additional neuroprotective activities for Alzheimer's disease.. Eur J Med Chem, 177 (414-424). [PMID:31158754] [10.1016/j.ejmech.2019.05.062]
125. Sharma P, Tripathi A, Tripathi PN, Prajapati SK, Seth A, Tripathi MK, Srivastava P, Tiwari V, Krishnamurthy S, Shrivastava SK.. (2019) Design and development of multitarget-directed N-Benzylpiperidine analogs as potential candidates for the treatment of Alzheimer's disease.. Eur J Med Chem, 167 (510-524). [PMID:30784883] [10.1016/j.ejmech.2019.02.030]
126. do Carmo Carreiras M, Ismaili L, Marco-Contelles J.. (2020) Propargylamine-derived multi-target directed ligands for Alzheimer's disease therapy.. Bioorg Med Chem Lett, 30 (3): (126880-126880). [PMID:31864798] [10.1016/j.bmcl.2019.126880]
127. Zhu Z,Yang T,Zhang L,Liu L,Yin E,Zhang C,Guo Z,Xu C,Wang X. (2019) Inhibiting Aβ toxicity in Alzheimer's disease by a pyridine amine derivative.. Eur J Med Chem, 168 (330-339). [PMID:30826509] [10.1016/j.ejmech.2019.02.052]
128. Tripathi A,Choubey PK,Sharma P,Seth A,Tripathi PN,Tripathi MK,Prajapati SK,Krishnamurthy S,Shrivastava SK. (2019) Design and development of molecular hybrids of 2-pyridylpiperazine and 5-phenyl-1,3,4-oxadiazoles as potential multifunctional agents to treat Alzheimer's disease.. Eur J Med Chem, 183 (111707-111707). [PMID:31561043] [10.1016/j.ejmech.2019.111707]
129. de Matos AM,Blázquez-Sánchez MT,Bento-Oliveira A,de Almeida RFM,Nunes R,Lopes PEM,Machuqueiro M,Cristóvão JS,Gomes CM,Souza CS,El Idrissi IG,Colabufo NA,Diniz A,Marcelo F,Oliveira MC,López Ó,Fernandez-Bolaños JG,Dätwyler P,Ernst B,Ning K,Garwood C,Chen B,Rauter AP. (2020) Glucosylpolyphenols as Inhibitors of Aβ-Induced Fyn Kinase Activation and Tau Phosphorylation: Synthesis, Membrane Permeability, and Exploratory Target Assessment within the Scope of Type 2 Diabetes and Alzheimer's Disease.. J Med Chem, 63 (20.0): (11663-11690). [PMID:32959649] [10.1021/acs.jmedchem.0c00841]
130. Tseng HJ,Lin MH,Shiao YJ,Yang YC,Chu JC,Chen CY,Chen YY,Lin TE,Su CJ,Pan SL,Chen LC,Wang CY,Hsu KC,Huang WJ. (2020) Synthesis and biological evaluation of acridine-based histone deacetylase inhibitors as multitarget agents against Alzheimer's disease.. Eur J Med Chem, 192 (112193-112193). [PMID:32151835] [10.1016/j.ejmech.2020.112193]
131. Sang Z,Wang K,Bai P,Wu A,Shi J,Liu W,Zhu G,Wang Y,Lan Y,Chen Z,Zhao Y,Qiao Z,Wang C,Tan Z. (2020) Design, synthesis and biological evaluation of novel O-carbamoyl ferulamide derivatives as multi-target-directed ligands for the treatment of Alzheimer's disease.. Eur J Med Chem, 194 (112265-112265). [PMID:32240904] [10.1016/j.ejmech.2020.112265]
132. Oliveri V. (2019) Toward the discovery and development of effective modulators of α-synuclein amyloid aggregation.. Eur J Med Chem, 167 (10-36). [PMID:30743095] [10.1016/j.ejmech.2019.01.045]
133. Choubey PK,Tripathi A,Sharma P,Shrivastava SK. (2020) Design, synthesis, and multitargeted profiling of N-benzylpyrrolidine derivatives for the treatment of Alzheimer's disease.. Bioorg Med Chem, 28 (22): (115721-115721). [PMID:33007563] [10.1016/j.bmc.2020.115721]
134. Sobolova K,Hrabinova M,Hepnarova V,Kucera T,Kobrlova T,Benkova M,Janockova J,Dolezal R,Prchal L,Benek O,Mezeiova E,Jun D,Soukup O,Korabecny J. (2020) Discovery of novel berberine derivatives with balanced cholinesterase and prolyl oligopeptidase inhibition profile.. Eur J Med Chem, 203 (112593-112593). [PMID:32688201] [10.1016/j.ejmech.2020.112593]
135. Erdogan M,Kilic B,Sagkan RI,Aksakal F,Ercetin T,Gulcan HO,Dogruer DS. (2021) Design, synthesis and biological evaluation of new benzoxazolone/benzothiazolone derivatives as multi-target agents against Alzheimer's disease.. Eur J Med Chem, 212 (113124-113124). [PMID:33395623] [10.1016/j.ejmech.2020.113124]
136. Cao Z,Song Q,Yu G,Liu Z,Cong S,Tan Z,Deng Y. (2021) Novel 3-benzylidene/benzylphthalide Mannich base derivatives as potential multifunctional agents for the treatment of Alzheimer's disease.. Bioorg Med Chem, 35 (116074-116074). [PMID:33640707] [10.1016/j.bmc.2021.116074]
137. Pérez-Areales FJ,Garrido M,Aso E,Bartolini M,De Simone A,Espargaró A,Ginex T,Sabate R,Pérez B,Andrisano V,Puigoriol-Illamola D,Pallàs M,Luque FJ,Loza MI,Brea J,Ferrer I,Ciruela F,Messeguer A,Muñoz-Torrero D. (2020) Centrally Active Multitarget Anti-Alzheimer Agents Derived from the Antioxidant Lead CR-6.. J Med Chem, 63 (17): (9360-9390). [PMID:32706255] [10.1021/acs.jmedchem.0c00528]
138. Sang Z, Song Q, Cao Z, Deng Y, Tan Z, Zhang L.. (2021) Design, synthesis and evaluation of novel dimethylamino chalcone-O-alkylamines derivatives as potential multifunctional agents against Alzheimer's disease.. Eur J Med Chem, 216 (113310-113310). [PMID:33667847] [10.1016/j.ejmech.2021.113310]
139. Mezeiova E, Janockova J, Andrys R, Soukup O, Kobrlova T, Muckova L, Pejchal J, Simunkova M, Handl J, Micankova P, Capek J, Rousar T, Hrabinova M, Nepovimova E, Marco-Contelles JL, Valko M, Korabecny J.. (2021) 2-Propargylamino-naphthoquinone derivatives as multipotent agents for the treatment of Alzheimer's disease.. Eur J Med Chem, 211 (113112-113112). [PMID:33360800] [10.1016/j.ejmech.2020.113112]
140. Mullan, M M and 6 more authors.. (1992) A pathogenic mutation for probable Alzheimer's disease in the APP gene at the N-terminus of beta-amyloid.. Nature genetics, [PMID:1302033]
141. Hendriks, L L and 9 more authors.. (1992) Presenile dementia and cerebral haemorrhage linked to a mutation at codon 692 of the beta-amyloid precursor protein gene.. Nature genetics, [PMID:1303239]
142. Carter, D A DA and 8 more authors.. (1992) More missense in amyloid gene.. Nature genetics, [PMID:1303275]
143. Jones, C T CT and 6 more authors.. (1992) Mutation in codon 713 of the beta amyloid precursor protein gene presenting with schizophrenia.. Nature genetics, [PMID:1307241]
144. Kamino, K K and 9 more authors.. (1992) Linkage and mutational analysis of familial Alzheimer disease kindreds for the APP gene region.. American journal of human genetics, [PMID:1415269]
145. Citron, M M and 8 more authors.. (1992) Mutation of the beta-amyloid precursor protein in familial Alzheimer's disease increases beta-protein production.. Nature, (17): [PMID:1465129]
146. König, G G and 8 more authors.. (1992) Identification and differential expression of a novel alternative splice isoform of the beta A4 amyloid precursor protein (APP) mRNA in leukocytes and brain microglial cells.. The Journal of biological chemistry, (25): [PMID:1587857]
147. Goate, A A and 9 more authors.. (1991) Segregation of a missense mutation in the amyloid precursor protein gene with familial Alzheimer's disease.. Nature, (21): [PMID:1671712]
148. Naruse, S S and 9 more authors.. (1991) Mis-sense mutation Val----Ile in exon 17 of amyloid precursor protein gene in Japanese familial Alzheimer's disease.. Lancet (London, England), (20): [PMID:1678058]
149. Heald, S L SL and 9 more authors.. (1991) Sequential NMR resonance assignment and structure determination of the Kunitz-type inhibitor domain of the Alzheimer's beta-amyloid precursor protein.. Biochemistry, (29): [PMID:1718421]
150. Yoshioka, K K, Miki, T T, Katsuya, T T, Ogihara, T T and Sakaki, Y Y.. (1991) The 717Val----Ile substitution in amyloid precursor protein is associated with familial Alzheimer's disease regardless of ethnic groups.. Biochemical and biophysical research communications, (15): [PMID:1908231]
151. Yoshikai, S S, Sasaki, H H, Doh-ura, K K, Furuya, H H and Sakaki, Y Y.. (1991) Genomic organization of the human-amyloid beta-protein precursor gene.. Gene, (30): [PMID:1908403]
152. Murrell, J J, Farlow, M M, Ghetti, B B and Benson, M D MD.. (1991) A mutation in the amyloid precursor protein associated with hereditary Alzheimer's disease.. Science (New York, N.Y.), (4): [PMID:1925564]
153. Chartier-Harlin, M C MC and 9 more authors.. (1991) Early-onset Alzheimer's disease caused by mutations at codon 717 of the beta-amyloid precursor protein gene.. Nature, (31): [PMID:1944558]
154. Kido, H H and 5 more authors.. (1990) Protease-specificity of Kunitz inhibitor domain of Alzheimer's disease amyloid protein precursor.. Biochemical and biophysical research communications, (16): [PMID:1969731]
155. Yoshikai, S S, Sasaki, H H, Doh-ura, K K, Furuya, H H and Sakaki, Y Y.. (1990) Genomic organization of the human amyloid beta-protein precursor gene.. Gene, (15): [PMID:2110105]
156. Levy, E E and 8 more authors.. (1990) Mutation of the Alzheimer's disease amyloid gene in hereditary cerebral hemorrhage, Dutch type.. Science (New York, N.Y.), (1): [PMID:2111584]
157. Hynes, T R TR, Randal, M M, Kennedy, L A LA, Eigenbrot, C C and Kossiakoff, A A AA.. (1990) X-ray crystal structure of the protease inhibitor domain of Alzheimer's amyloid beta-protein precursor.. Biochemistry, (30): [PMID:2125487]
158. Oltersdorf, T T and 9 more authors.. (1989) The secreted form of the Alzheimer's amyloid precursor protein with the Kunitz domain is protease nexin-II.. Nature, (14): [PMID:2506449]
159. La Fauci, G G, Lahiri, D K DK, Salton, S R SR and Robakis, N K NK.. (1989) Characterization of the 5'-end region and the first two exons of the beta-protein precursor gene.. Biochemical and biophysical research communications, (28): [PMID:2538123]
160. de Sauvage, F F and Octave, J N JN.. (1989) A novel mRNA of the A4 amyloid precursor gene coding for a possibly secreted protein.. Science (New York, N.Y.), (11): [PMID:2569763]
161. Weidemann, A A and 6 more authors.. (1989) Identification, biogenesis, and localization of precursors of Alzheimer's disease A4 amyloid protein.. Cell, (7): [PMID:2649245]
162. Johnstone, E M EM and 5 more authors.. (1989) Alzheimer's disease amyloid peptide is encoded by two exons and shows similarity to soybean trypsin inhibitor.. Biochemical and biophysical research communications, (29): [PMID:2675837]
163. Lemaire, H G HG and 7 more authors.. (1989) The PreA4(695) precursor protein of Alzheimer's disease A4 amyloid is encoded by 16 exons.. Nucleic acids research, (25): [PMID:2783775]
164. Ponte, P P and 9 more authors.. (1988) A new A4 amyloid mRNA contains a domain homologous to serine proteinase inhibitors.. Nature, (11): [PMID:2893289]
165. Tanzi, R E RE and 5 more authors.. (1988) Protease inhibitor domain encoded by an amyloid protein precursor mRNA associated with Alzheimer's disease.. Nature, (11): [PMID:2893290]
166. Kitaguchi, N N, Takahashi, Y Y, Tokushima, Y Y, Shiojiri, S S and Ito, H H.. (1988) Novel precursor of Alzheimer's disease amyloid protein shows protease inhibitory activity.. Nature, (11): [PMID:2893291]
167. Zain, S B SB and 5 more authors.. (1988) Molecular cloning of amyloid cDNA derived from mRNA of the Alzheimer disease brain: coding and noncoding regions of the fetal precursor mRNA are expressed in the cortex.. Proceedings of the National Academy of Sciences of the United States of America, [PMID:2893379]
168. Dyrks, T T and 8 more authors.. (1988) Identification, transmembrane orientation and biogenesis of the amyloid A4 precursor of Alzheimer's disease.. The EMBO journal, [PMID:2900137]
169. Tanzi, R E RE and 9 more authors.. (1987) Amyloid beta protein gene: cDNA, mRNA distribution, and genetic linkage near the Alzheimer locus.. Science (New York, N.Y.), (20): [PMID:2949367]
170. Robakis, N K NK, Ramakrishna, N N, Wolfe, G G and Wisniewski, H M HM.. (1987) Molecular cloning and characterization of a cDNA encoding the cerebrovascular and the neuritic plaque amyloid peptides.. Proceedings of the National Academy of Sciences of the United States of America, [PMID:3035574]
171. Mita, S S, Sadlock, J J, Herbert, J J and Schon, E A EA.. (1988) A cDNA specifying the human amyloid beta precursor protein (ABPP) encodes a 95-kDa polypeptide.. Nucleic acids research, (11): [PMID:3140222]
172. Pardridge, W M WM and 7 more authors.. (1987) Amyloid angiopathy of Alzheimer's disease: amino acid composition and partial sequence of a 4,200-dalton peptide isolated from cortical microvessels.. Journal of neurochemistry, [PMID:3312495]
173. Van Nostrand, W E WE and Cunningham, D D DD.. (1987) Purification of protease nexin II from human fibroblasts.. The Journal of biological chemistry, (25): [PMID:3597385]
174. Goldgaber, D D, Lerman, M I MI, McBride, O W OW, Saffiotti, U U and Gajdusek, D C DC.. (1987) Characterization and chromosomal localization of a cDNA encoding brain amyloid of Alzheimer's disease.. Science (New York, N.Y.), (20): [PMID:3810169]
175. Talafous, J J, Marcinowski, K J KJ, Klopman, G G and Zagorski, M G MG.. (1994) Solution structure of residues 1-28 of the amyloid beta-peptide.. Biochemistry, (28): [PMID:7516706]
176. Sticht, H H and 7 more authors.. (1995) Structure of amyloid A4-(1-40)-peptide of Alzheimer's disease.. European journal of biochemistry, (1): [PMID:7588758]
177. Pangalos, M N MN, Efthimiopoulos, S S, Shioi, J J and Robakis, N K NK.. (1995) The chondroitin sulfate attachment site of appican is formed by splicing out exon 15 of the amyloid precursor gene.. The Journal of biological chemistry, (5): [PMID:7737970]
178. Hesse, L L, Beher, D D, Masters, C L CL and Multhaup, G G.. (1994) The beta A4 amyloid precursor protein binding to copper.. FEBS letters, (25): [PMID:7913895]
179. Wisniewski, T T, Lalowski, M M, Levy, E E, Marques, M R MR and Frangione, B B.. (1994) The amino acid sequence of neuritic plaque amyloid from a familial Alzheimer's disease patient.. Annals of neurology, [PMID:8109908]
180. Suzuki, T T and 5 more authors.. (1994) Cell cycle-dependent regulation of the phosphorylation and metabolism of the Alzheimer amyloid precursor protein.. The EMBO journal, (1): [PMID:8131745]
181. Peacock, M L ML and 5 more authors.. (1994) Novel amyloid precursor protein gene mutation (codon 665Asp) in a patient with late-onset Alzheimer's disease.. Annals of neurology, [PMID:8154870]
182. Small, D H DH and 6 more authors.. (1994) A heparin-binding domain in the amyloid protein precursor of Alzheimer's disease is involved in the regulation of neurite outgrowth.. The Journal of neuroscience : the official journal of the Society for Neuroscience, [PMID:8158260]
183. Vigo-Pelfrey, C C, Lee, D D, Keim, P P, Lieberburg, I I and Schenk, D B DB.. (1993) Characterization of beta-amyloid peptide from human cerebrospinal fluid.. Journal of neurochemistry, [PMID:8229004]
184. Roher, A E AE and 6 more authors.. (1993) beta-Amyloid-(1-42) is a major component of cerebrovascular amyloid deposits: implications for the pathology of Alzheimer disease.. Proceedings of the National Academy of Sciences of the United States of America, (15): [PMID:8248178]
185. Liepnieks, J J JJ, Ghetti, B B, Farlow, M M, Roses, A D AD and Benson, M D MD.. (1993) Characterization of amyloid fibril beta-peptide in familial Alzheimer's disease with APP717 mutations.. Biochemical and biophysical research communications, (15): [PMID:8267572]
186. Farlow, M M and 5 more authors.. (1994) Clinical characteristics in a kindred with early-onset Alzheimer's disease and their linkage to a G-->T change at position 2149 of the amyloid precursor protein gene.. Neurology, [PMID:8290042]
187. Bush, A I AI and 8 more authors.. (1993) A novel zinc(II) binding site modulates the function of the beta A4 amyloid protein precursor of Alzheimer's disease.. The Journal of biological chemistry, (5): [PMID:8344894]
188. Arispe, N N, Rojas, E E and Pollard, H B HB.. (1993) Alzheimer disease amyloid beta protein forms calcium channels in bilayer membranes: blockade by tromethamine and aluminum.. Proceedings of the National Academy of Sciences of the United States of America, (15): [PMID:8380642]
189. Nishimoto, I I and 6 more authors.. (1993) Alzheimer amyloid protein precursor complexes with brain GTP-binding protein G(o). Nature, (4): [PMID:8446172]
190. Denman, R B RB, Rosenzcwaig, R R and Miller, D L DL.. (1993) A system for studying the effect(s) of familial Alzheimer disease mutations on the processing of the beta-amyloid peptide precursor.. Biochemical and biophysical research communications, (15): [PMID:8476439]
191. Beher, D D, Hesse, L L, Masters, C L CL and Multhaup, G G.. (1996) Regulation of amyloid protein precursor (APP) binding to collagen and mapping of the binding sites on APP and collagen type I.. The Journal of biological chemistry, (19): [PMID:8576160]
192. Brooks, W S WS and 8 more authors.. (1995) A mutation in codon 717 of the amyloid precursor protein gene in an Australian family with Alzheimer's disease.. Neuroscience letters, (27): [PMID:8577393]
193. Chow, N N, Korenberg, J R JR, Chen, X N XN and Neve, R L RL.. (1996) APP-BP1, a novel protein that binds to the carboxyl-terminal region of the amyloid precursor protein.. The Journal of biological chemistry, (10): [PMID:8626687]
194. Guénette, S Y SY, Chen, J J, Jondro, P D PD and Tanzi, R E RE.. (1996) Association of a novel human FE65-like protein with the cytoplasmic domain of the beta-amyloid precursor protein.. Proceedings of the National Academy of Sciences of the United States of America, (1): [PMID:8855266]
195. Maruyama, K K and 8 more authors.. (1996) Familial Alzheimer's disease-linked mutations at Val717 of amyloid precursor protein are specific for the increased secretion of A beta 42(43).. Biochemical and biophysical research communications, (23): [PMID:8886002]
196. Borg, J P JP, Ooi, J J, Levy, E E and Margolis, B B.. (1996) The phosphotyrosine interaction domains of X11 and FE65 bind to distinct sites on the YENPTY motif of amyloid precursor protein.. Molecular and cellular biology, [PMID:8887653]
197. Kohno, T T, Kobayashi, K K, Maeda, T T, Sato, K K and Takashima, A A.. (1996) Three-dimensional structures of the amyloid beta peptide (25-35) in membrane-mimicking environment.. Biochemistry, (17): [PMID:8973180]
198. Walter, J J and 8 more authors.. (1997) Ectodomain phosphorylation of beta-amyloid precursor protein at two distinct cellular locations.. The Journal of biological chemistry, (17): [PMID:8999878]
199. Hattori, M M and 7 more authors.. (1997) A novel method for making nested deletions and its application for sequencing of a 300 kb region of human APP locus.. Nucleic acids research, (1): [PMID:9108164]
200. Walter, M F MF, Mason, P E PE and Mason, R P RP.. (1997) Alzheimer's disease amyloid beta peptide 25-35 inhibits lipid peroxidation as a result of its membrane interactions.. Biochemical and biophysical research communications, (28): [PMID:9168929]
201. Scheidig, A J AJ, Hynes, T R TR, Pelletier, L A LA, Wells, J A JA and Kossiakoff, A A AA.. (1997) Crystal structures of bovine chymotrypsin and trypsin complexed to the inhibitor domain of Alzheimer's amyloid beta-protein precursor (APPI) and basic pancreatic trypsin inhibitor (BPTI): engineering of inhibitors with altered specificities.. Protein science : a publication of the Protein Society, [PMID:9300481]
202. Eckman, C B CB and 14 more authors.. (1997) A new pathogenic mutation in the APP gene (I716V) increases the relative proportion of A beta 42(43).. Human molecular genetics, [PMID:9328472]
203. Yan, S D SD and 13 more authors.. (1997) An intracellular protein that binds amyloid-beta peptide and mediates neurotoxicity in Alzheimer's disease.. Nature, (16): [PMID:9338779]
204. Mok, S S SS and 9 more authors.. (1997) Expression and analysis of heparin-binding regions of the amyloid precursor protein of Alzheimer's disease.. FEBS letters, (6): [PMID:9357988]
205. Multhaup, G G and 7 more authors.. (1998) Copper-binding amyloid precursor protein undergoes a site-specific fragmentation in the reduction of hydrogen peroxide.. Biochemistry, (19): [PMID:9585534]
206. Coles, M M, Bicknell, W W, Watson, A A AA, Fairlie, D P DP and Craik, D J DJ.. (1998) Solution structure of amyloid beta-peptide(1-40) in a water-micelle environment. Is the membrane-spanning domain where we think it is?. Biochemistry, (4): [PMID:9693002]
207. Cras, P P and 9 more authors.. (1998) Presenile Alzheimer dementia characterized by amyloid angiopathy and large amyloid core type senile plaques in the APP 692Ala-->Gly mutation.. Acta neuropathologica, [PMID:9754958]
208. Zheng, P P, Eastman, J J, Vande Pol, S S and Pimplikar, S W SW.. (1998) PAT1, a microtubule-interacting protein, recognizes the basolateral sorting signal of amyloid precursor protein.. Proceedings of the National Academy of Sciences of the United States of America, (8): [PMID:9843960]
209. Tomita, S S and 8 more authors.. (1999) Interaction of a neuron-specific protein containing PDZ domains with Alzheimer's amyloid precursor protein.. The Journal of biological chemistry, (22): [PMID:9890987]
210. Tanahashi, H H and Tabira, T T.. (1999) Molecular cloning of human Fe65L2 and its interaction with the Alzheimer's beta-amyloid precursor protein.. Neuroscience letters, (19): [PMID:10081969]
211. Ancolio, K K and 7 more authors.. (1999) Unusual phenotypic alteration of beta amyloid precursor protein (betaAPP) maturation by a new Val-715 --> Met betaAPP-770 mutation responsible for probable early-onset Alzheimer's disease.. Proceedings of the National Academy of Sciences of the United States of America, (30): [PMID:10097173]
212. Rossjohn, J J and 10 more authors.. (1999) Crystal structure of the N-terminal, growth factor-like domain of Alzheimer amyloid precursor protein.. Nature structural biology, [PMID:10201399]
213. Gervais, F G FG and 18 more authors.. (1999) Involvement of caspases in proteolytic cleavage of Alzheimer's amyloid-beta precursor protein and amyloidogenic A beta peptide formation.. Cell, (30): [PMID:10319819]
214. Ando, K K and 8 more authors.. (1999) Role of phosphorylation of Alzheimer's amyloid precursor protein during neuronal differentiation.. The Journal of neuroscience : the official journal of the Society for Neuroscience, (1): [PMID:10341243]
215. Perez, R G RG and 8 more authors.. (1999) Mutagenesis identifies new signals for beta-amyloid precursor protein endocytosis, turnover, and the generation of secreted fragments, including Abeta42.. The Journal of biological chemistry, (2): [PMID:10383380]
216. Liu, S T ST, Howlett, G G and Barrow, C J CJ.. (1999) Histidine-13 is a crucial residue in the zinc ion-induced aggregation of the A beta peptide of Alzheimer's disease.. Biochemistry, (20): [PMID:10413512]
217. Ruiz, F H FH, González, M M, Bodini, M M, Opazo, C C and Inestrosa, N C NC.. (1999) Cysteine 144 is a key residue in the copper reduction by the beta-amyloid precursor protein.. Journal of neurochemistry, [PMID:10461923]
218. Varadarajan, S S, Yatin, S S, Kanski, J J, Jahanshahi, F F and Butterfield, D A DA.. (1999) Methionine residue 35 is important in amyloid beta-peptide-associated free radical oxidative stress.. Brain research bulletin, (15): [PMID:10535332]
219. Finckh, U U and 10 more authors.. (2000) High prevalence of pathogenic mutations in patients with early-onset dementia detected by sequence analyses of four different genes.. American journal of human genetics, [PMID:10631141]
220. Hussain, I I and 14 more authors.. (1999) Identification of a novel aspartic protease (Asp 2) as beta-secretase.. Molecular and cellular neurosciences, [PMID:10656250]
221. Kwok, J B JB and 7 more authors.. (2000) Novel Leu723Pro amyloid precursor protein mutation increases amyloid beta42(43) peptide levels and induces apoptosis.. Annals of neurology, [PMID:10665499]
222. Lin, X X and 5 more authors.. (2000) Human aspartic protease memapsin 2 cleaves the beta-secretase site of beta-amyloid precursor protein.. Proceedings of the National Academy of Sciences of the United States of America, (15): [PMID:10677483]
223. Wang, H Y HY and 5 more authors.. (2000) beta-Amyloid(1-42) binds to alpha7 nicotinic acetylcholine receptor with high affinity. Implications for Alzheimer's disease pathology.. The Journal of biological chemistry, (25): [PMID:10681545]
224. Lu, D C DC and 8 more authors.. (2000) A second cytotoxic proteolytic peptide derived from amyloid beta-protein precursor.. Nature medicine, [PMID:10742146]
225. Walter, J J, Schindzielorz, A A, Hartung, B B and Haass, C C.. (2000) Phosphorylation of the beta-amyloid precursor protein at the cell surface by ectocasein kinases 1 and 2.. The Journal of biological chemistry, (4): [PMID:10806211]
226. Tokuda, T T and 11 more authors.. (2000) Lipidation of apolipoprotein E influences its isoform-specific interaction with Alzheimer's amyloid beta peptides.. The Biochemical journal, (1): [PMID:10816430]
227. Miravalle, L L and 7 more authors.. (2000) Substitutions at codon 22 of Alzheimer's abeta peptide induce diverse conformational changes and apoptotic effects in human cerebral endothelial cells.. The Journal of biological chemistry, (1): [PMID:10821838]
228. Hattori, M M and 64 more authors.. (2000) The DNA sequence of human chromosome 21.. Nature, (18): [PMID:10830953]
229. Murrell, J R JR, Hake, A M AM, Quaid, K A KA, Farlow, M R MR and Ghetti, B B.. (2000) Early-onset Alzheimer disease caused by a new mutation (V717L) in the amyloid precursor protein gene.. Archives of neurology, [PMID:10867787]
230. Zhang, S S and 9 more authors.. (2000) The Alzheimer's peptide a beta adopts a collapsed coil structure in water.. Journal of structural biology, [PMID:10940221]
231. Poulsen, S A SA, Watson, A A AA, Fairlie, D P DP and Craik, D J DJ.. (2000) Solution structures in aqueous SDS micelles of two amyloid beta peptides of A beta(1-28) mutated at the alpha-secretase cleavage site (K16E, K16F).. Journal of structural biology, [PMID:10940222]
232. Kumar-Singh, S S and 13 more authors.. (2000) Nonfibrillar diffuse amyloid deposition due to a gamma(42)-secretase site mutation points to an essential role for N-truncated A beta(42) in Alzheimer's disease.. Human molecular genetics, (1): [PMID:11063718]
233. Standen, C L CL and 6 more authors.. (2001) Phosphorylation of thr(668) in the cytoplasmic domain of the Alzheimer's disease amyloid precursor protein by stress-activated protein kinase 1b (Jun N-terminal kinase-3).. Journal of neurochemistry, [PMID:11146006]
234. Ohsawa, I I, Takamura, C C and Kohsaka, S S.. (2001) Fibulin-1 binds the amino-terminal head of beta-amyloid precursor protein and modulates its physiological function.. Journal of neurochemistry, [PMID:11238726]
235. Curtain, C C CC and 9 more authors.. (2001) Alzheimer's disease amyloid-beta binds copper and zinc to generate an allosterically ordered membrane-penetrating structure containing superoxide dismutase-like subunits.. The Journal of biological chemistry, (8): [PMID:11274207]
236. Kajkowski, E M EM and 18 more authors.. (2001) beta -Amyloid peptide-induced apoptosis regulated by a novel protein containing a g protein activation module.. The Journal of biological chemistry, (1): [PMID:11278849]
237. Grabowski, T J TJ, Cho, H S HS, Vonsattel, J P JP, Rebeck, G W GW and Greenberg, S M SM.. (2001) Novel amyloid precursor protein mutation in an Iowa family with dementia and severe cerebral amyloid angiopathy.. Annals of neurology, [PMID:11409420]
238. Scheuermann, S S and 8 more authors.. (2001) Homodimerization of amyloid precursor protein and its implication in the amyloidogenic pathway of Alzheimer's disease.. The Journal of biological chemistry, (7): [PMID:11438549]
239. Ando, K K, Iijima, K I KI, Elliott, J I JI, Kirino, Y Y and Suzuki, T T.. (2001) Phosphorylation-dependent regulation of the interaction of amyloid precursor protein with Fe65 affects the production of beta-amyloid.. The Journal of biological chemistry, (26): [PMID:11517218]
240. Nilsberth, C C and 11 more authors.. (2001) The 'Arctic' APP mutation (E693G) causes Alzheimer's disease by enhanced Abeta protofibril formation.. Nature neuroscience, [PMID:11528419]
241. Kimberly, W T WT, Zheng, J B JB, Guénette, S Y SY and Selkoe, D J DJ.. (2001) The intracellular domain of the beta-amyloid precursor protein is stabilized by Fe65 and translocates to the nucleus in a notch-like manner.. The Journal of biological chemistry, (26): [PMID:11544248]
242. Hu, J J, Igarashi, A A, Kamata, M M and Nakagawa, H H.. (2001) Angiotensin-converting enzyme degrades Alzheimer amyloid beta-peptide (A beta ); retards A beta aggregation, deposition, fibril formation; and inhibits cytotoxicity.. The Journal of biological chemistry, (21): [PMID:11604391]
243. Scheinfeld, Meir H MH and 5 more authors.. (2002) Jun NH2-terminal kinase (JNK) interacting protein 1 (JIP1) binds the cytoplasmic domain of the Alzheimer's beta-amyloid precursor protein (APP).. The Journal of biological chemistry, (1): [PMID:11724784]
244. and Kontush, A A.. (2001) Alzheimer's amyloid-beta as a preventive antioxidant for brain lipoproteins.. Cellular and molecular neurobiology, [PMID:11775062]
245. White, Anthony R AR and 8 more authors.. (2002) Contrasting, species-dependent modulation of copper-mediated neurotoxicity by the Alzheimer's disease amyloid precursor protein.. The Journal of neuroscience : the official journal of the Society for Neuroscience, (15): [PMID:11784781]
246. Weidemann, Andreas A and 8 more authors.. (2002) A novel epsilon-cleavage within the transmembrane domain of the Alzheimer amyloid precursor protein demonstrates homology with Notch processing.. Biochemistry, (26): [PMID:11851430]
247. Tarr, Philip E PE, Roncarati, Roberta R, Pelicci, Giuliana G, Pelicci, Pier Giuseppe PG and D'Adamio, Luciano L.. (2002) Tyrosine phosphorylation of the beta-amyloid precursor protein cytoplasmic tail promotes interaction with Shc.. The Journal of biological chemistry, (10): [PMID:11877420]
248. Rank, Kenneth B KB and 7 more authors.. (2002) Direct interaction of soluble human recombinant tau protein with Abeta 1-42 results in tau aggregation and hyperphosphorylation by tau protein kinase II.. FEBS letters, (13): [PMID:11943163]
249. Bush, Ashley I AI and Tanzi, Rudolph E RE.. (2002) The galvanization of beta-amyloid in Alzheimer's disease.. Proceedings of the National Academy of Sciences of the United States of America, (28): [PMID:12032279]
250. Pasalar, P P and 8 more authors.. (2002) An Iranian family with Alzheimer's disease caused by a novel APP mutation (Thr714Ala).. Neurology, (28): [PMID:12034808]
251. Annaert, Wim W and De Strooper, Bart B.. (2002) A cell biological perspective on Alzheimer's disease.. Annual review of cell and developmental biology, [PMID:12142279]
252. Passer, B B and 8 more authors.. (2000) Generation of an apoptotic intracellular peptide by gamma-secretase cleavage of Alzheimer's amyloid beta protein precursor.. Journal of Alzheimer's disease : JAD, [PMID:12214090]
253. Barnham, Kevin J KJ and 13 more authors.. (2003) Structure of the Alzheimer's disease amyloid precursor protein copper binding domain. A regulator of neuronal copper homeostasis.. The Journal of biological chemistry, (9): [PMID:12611883]
254. Greenberg, S M SM and 8 more authors.. (2003) Hemorrhagic stroke associated with the Iowa amyloid precursor protein mutation.. Neurology, (25): [PMID:12654973]
255. Gevaert, Kris K and 6 more authors.. (2003) Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides.. Nature biotechnology, [PMID:12665801]
256. Tang, Ke K and 5 more authors.. (2003) Identification of a novel alternative splicing isoform of human amyloid precursor protein gene, APP639.. The European journal of neuroscience, [PMID:12859342]
257. Chang, Yang Y and 7 more authors.. (2003) Generation of the beta-amyloid peptide and the amyloid precursor protein C-terminal fragment gamma are potentiated by FE65L1.. The Journal of biological chemistry, (19): [PMID:14527950]
258. Watanabe, Norifumi N and 5 more authors.. (2004) Glypican-1 as an Abeta binding HSPG in the human brain: its localization in DIG domains and possible roles in the pathogenesis of Alzheimer's disease.. FASEB journal : official publication of the Federation of American Societies for Experimental Biology, [PMID:15084524]
259. Wakutani, Y Y and 9 more authors.. (2004) Novel amyloid precursor protein gene missense mutation (D678N) in probable familial Alzheimer's disease.. Journal of neurology, neurosurgery, and psychiatry, [PMID:15201367]
260. Wang, Yongcheng Y and Ha, Ya Y.. (2004) The X-ray structure of an antiparallel dimer of the human amyloid precursor protein E2 domain.. Molecular cell, (13): [PMID:15304215]
261. Ghersi, Enrico E, Noviello, Cristiana C and D'Adamio, Luciano L.. (2004) Amyloid-beta protein precursor (AbetaPP) intracellular domain-associated protein-1 proteins bind to AbetaPP and modulate its processing in an isoform-specific manner.. The Journal of biological chemistry, (19): [PMID:15347684]
262. Rossi, G G and 13 more authors.. (2004) A family with Alzheimer disease and strokes associated with A713T mutation of the APP gene.. Neurology, (14): [PMID:15365148]
263. Edwards-Lee, T T and 10 more authors.. (2005) An African American family with early-onset Alzheimer disease and an APP (T714I) mutation.. Neurology, (25): [PMID:15668448]
264. Venti, Amanda A and 6 more authors.. (2004) The integrated role of desferrioxamine and phenserine targeted to an iron-responsive element in the APP-mRNA 5'-untranslated region.. Annals of the New York Academy of Sciences, [PMID:15681799]
265. Hemming, Matthew L ML and Selkoe, Dennis J DJ.. (2005) Amyloid beta-protein is degraded by cellular angiotensin-converting enzyme (ACE) and elevated by an ACE inhibitor.. The Journal of biological chemistry, (11): [PMID:16154999]
266. Andersen, Olav M OM and 18 more authors.. (2005) Neuronal sorting protein-related receptor sorLA/LR11 regulates processing of the amyloid precursor protein.. Proceedings of the National Academy of Sciences of the United States of America, (20): [PMID:16174740]
267. Obici, Laura L and 12 more authors.. (2005) A novel AbetaPP mutation exclusively associated with cerebral amyloid angiopathy.. Annals of neurology, [PMID:16178030]
268. Liu, Tao T and 6 more authors.. Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry.. Journal of proteome research, [PMID:16335952]
269. Spoelgen, Robert R and 9 more authors.. (2006) Interaction of the cytosolic domains of sorLA/LR11 with the amyloid precursor protein (APP) and beta-secretase beta-site APP-cleaving enzyme.. The Journal of neuroscience : the official journal of the Society for Neuroscience, (11): [PMID:16407538]
270. Sun, Xiulian X, He, Guiqiong G and Song, Weihong W.. (2006) BACE2, as a novel APP theta-secretase, is not responsible for the pathogenesis of Alzheimer's disease in Down syndrome.. FASEB journal : official publication of the Federation of American Societies for Experimental Biology, [PMID:16816112]
271. Shen, Yuequan Y, Joachimiak, Andrzej A, Rosner, Marsha Rich MR and Tang, Wei-Jen WJ.. (2006) Structures of human insulin-degrading enzyme reveal a new substrate recognition mechanism.. Nature, (19): [PMID:17051221]
272. Kong, Geoffrey K-W GK and 10 more authors.. (2007) Structural studies of the Alzheimer's amyloid precursor protein copper-binding domain reveal how it binds copper ions.. Journal of molecular biology, (16): [PMID:17239395]
273. Ahn, Jung Sun JS, Lee, Jung-Ho JH, Kim, Je-Hoon JH and Paik, Seung R SR.. (2007) Novel method for quantitative determination of amyloid fibrils of alpha-synuclein and amyloid beta/A4 protein by using resveratrol.. Analytical biochemistry, (15): [PMID:17597573]
274. Schmidt, Vanessa V and 6 more authors.. (2007) SorLA/LR11 regulates processing of amyloid precursor protein via interaction with adaptors GGA and PACS-1.. The Journal of biological chemistry, (9): [PMID:17855360]
275. Gardberg, Anna S AS and 9 more authors.. (2007) Molecular basis for passive immunotherapy of Alzheimer's disease.. Proceedings of the National Academy of Sciences of the United States of America, (2): [PMID:17895381]
276. Kong, Geoffrey Kwai-Wai GK, Adams, Julian J JJ, Cappai, Roberto R and Parker, Michael W MW.. (2007) Structure of Alzheimer's disease amyloid precursor protein copper-binding domain at atomic resolution.. Acta crystallographica. Section F, Structural biology and crystallization communications, (1): [PMID:17909280]
277. Nakaya, Tadashi T, Kawai, Tomoko T and Suzuki, Toshiharu T.. (2008) Regulation of FE65 nuclear translocation and function by amyloid beta-protein precursor in osmotically stressed cells.. The Journal of biological chemistry, (4): [PMID:18468999]
278. Nikolaev, Anatoly A, McLaughlin, Todd T, O'Leary, Dennis D M DD and Tessier-Lavigne, Marc M.. (2009) APP binds DR6 to trigger axon pruning and neuron death via distinct caspases.. Nature, (19): [PMID:19225519]
279. Matsuda, Shuji S, Matsuda, Yukiko Y and D'Adamio, Luciano L.. (2009) BRI3 inhibits amyloid precursor protein processing in a mechanistically distinct manner from its homologue dementia gene BRI2.. The Journal of biological chemistry, (5): [PMID:19366692]
280. Takuma, Kazuhiro K and 17 more authors.. (2009) RAGE-mediated signaling contributes to intraneuronal transport of amyloid-beta and neuronal dysfunction.. Proceedings of the National Academy of Sciences of the United States of America, (24): [PMID:19901339]
281. Dahms, Sven O SO and 5 more authors.. (2010) Structure and biochemical analysis of the heparin-induced E1 dimer of the amyloid precursor protein.. Proceedings of the National Academy of Sciences of the United States of America, (23): [PMID:20212142]
282. Cossec, Jack-Christophe JC and 8 more authors.. (2010) Clathrin-dependent APP endocytosis and Abeta secretion are highly sensitive to the level of plasma membrane cholesterol.. Biochimica et biophysica acta, [PMID:20580937]
283. Bugiani, Orso O and 19 more authors.. (2010) Hereditary cerebral hemorrhage with amyloidosis associated with the E693K mutation of APP.. Archives of neurology, [PMID:20697050]
284. He, Gen G and 10 more authors.. (2010) Gamma-secretase activating protein is a therapeutic target for Alzheimer's disease.. Nature, (2): [PMID:20811458]
285. Halim, Adnan A and 8 more authors.. (2011) Site-specific characterization of threonine, serine, and tyrosine glycosylations of amyloid precursor protein/amyloid beta-peptides in human cerebrospinal fluid.. Proceedings of the National Academy of Sciences of the United States of America, (19): [PMID:21712440]
286. Zhang, Ce C, Liu, Yonggang Y, Gilthorpe, Jonathan J and van der Maarel, Johan R C JR.. (2012) MRP14 (S100A9) protein interacts with Alzheimer beta-amyloid peptide and induces its fibrillization.. PloS one, [PMID:22457725]
287. Brinkmalm, Gunnar G and 15 more authors.. (2012) An online nano-LC-ESI-FTICR-MS method for comprehensive characterization of endogenous fragments from amyloid β and amyloid precursor protein in human and cat cerebrospinal fluid.. Journal of mass spectrometry : JMS, [PMID:22576872]
288. Nadezhdin, Kirill D KD, Bocharova, Olga V OV, Bocharov, Eduard V EV and Arseniev, Alexander S AS.. (2012) Dimeric structure of transmembrane domain of amyloid precursor protein in micellar environment.. FEBS letters, (12): [PMID:22584060]
289. Barrett, Paul J PJ and 7 more authors.. (2012) The amyloid precursor protein has a flexible transmembrane domain and binds cholesterol.. Science (New York, N.Y.), (1): [PMID:22654059]
290. Seamster, Pamela E and 6 more authors.. (2012) Quantitative measurements and modeling of cargo-motor interactions during fast transport in the living axon.. Physical biology, [PMID:23011729]
291. Sato, Mizuho M and 8 more authors.. (2013) Site-specific inhibitory mechanism for amyloid β42 aggregation by catechol-type flavonoids targeting the Lys residues.. The Journal of biological chemistry, (9): [PMID:23792961]
292. Cruchaga, Carlos C and 58 more authors.. (2014) Rare coding variants in the phospholipase D3 gene confer risk for Alzheimer's disease.. Nature, (23): [PMID:24336208]
293. Caglayan, Safak S and 11 more authors.. (2014) Lysosomal sorting of amyloid-β by the SORLA receptor is impaired by a familial Alzheimer's disease mutation.. Science translational medicine, (12): [PMID:24523320]
294. Baumkötter, Frederik F and 13 more authors.. (2014) Amyloid precursor protein dimerization and synaptogenic function depend on copper binding to the growth factor-like domain.. The Journal of neuroscience : the official journal of the Society for Neuroscience, (13): [PMID:25122912]
295. Fernandez-Echevarria, C C, Díaz, M M, Ferrer, I I, Canerina-Amaro, A A and Marin, R R.. (2014) Aβ promotes VDAC1 channel dephosphorylation in neuronal lipid rafts. Relevance to the mechanisms of neurotoxicity in Alzheimer's disease.. Neuroscience, (10): [PMID:25168729]
296. Tagliabracci, Vincent S VS and 14 more authors.. (2015) A Single Kinase Generates the Majority of the Secreted Phosphoproteome.. Cell, (18): [PMID:26091039]
297. Istrate, Andrey N and 7 more authors.. (2016) Interplay of histidine residues of the Alzheimer's disease Aβ peptide governs its Zn-induced oligomerization.. Scientific reports, (22): [PMID:26898943]
298. Polshakov, Vladimir I VI and 9 more authors.. (2017) A Binuclear Zinc Interaction Fold Discovered in the Homodimer of Alzheimer's Amyloid-β Fragment with Taiwanese Mutation D7H.. Angewandte Chemie (International ed. in English), (18): [PMID:28570778]
299. Gremer, Lothar L and 11 more authors.. (2017) Fibril structure of amyloid-β(1-42) by cryo-electron microscopy.. Science (New York, N.Y.), (6): [PMID:28882996]
300. Krotee, Pascal P and 14 more authors.. (2018) Common fibrillar spines of amyloid-β and human islet amyloid polypeptide revealed by microelectron diffraction and structure-based inhibitors.. The Journal of biological chemistry, (23): [PMID:29282295]
301. Arndt, Joseph W and 11 more authors.. (2018) Structural and kinetic basis for the selectivity of aducanumab for aggregated forms of amyloid-β.. Scientific reports, (23): [PMID:29686315]
302. Zhou, Rui R and 5 more authors.. (2019) Recognition of the amyloid precursor protein by human γ-secretase.. Science (New York, N.Y.), (15): [PMID:30630874]
303. and Hardy, J J.. (1992) Framing beta-amyloid.. Nature genetics, [PMID:1363811]
304. Scheiner M, Dolles D, Gunesch S, Hoffmann M, Nabissi M, Marinelli O, Naldi M, Bartolini M, Petralla S, Poeta E, Monti B, Falkeis C, Vieth M, Hübner H, Gmeiner P, Maitra R, Maurice T, Decker M.. (2019) Dual-Acting Cholinesterase-Human Cannabinoid Receptor 2 Ligands Show Pronounced Neuroprotection in Vitro and Overadditive and Disease-Modifying Neuroprotective Effects in Vivo.. J Med Chem, 62 (20): (9078-9102). [PMID:31609608] [10.1021/acs.jmedchem.9b00623]

溶液计算器

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计算溶液所需的质量、体积或浓度。

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稀释计算器

计算配制储备溶液所需的稀释度。

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复溶计算器

复溶计算器允许您快速计算试剂的体积，以复溶小瓶。只需输入试剂的质量和目标浓度，计算器将确定其余部分。

体积（添加到小瓶中）

质量（小瓶）

所需的复溶浓度

货号 (SKU)	包装规格	是否现货
Ab175575-100μg	100μg	现货
Ab175575-1mg	1mg	现货
Ab175575-5mg	5mg	现货
Ab175575-10mg	10mg	期货

Lecanemab (anti-Amyloid Beta), Beta 淀粉样蛋白 A4 蛋白抑制剂

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参考文献

溶液计算器

摩尔浓度计算器

稀释计算器

复溶计算器

Lecanemab (anti-Amyloid Beta), Beta 淀粉样蛋白 A4 蛋白抑制剂

库存信息

库存信息

库存信息

库存信息

基本信息

产品属性

图片

关联靶点（人）

作用机制

安全和危险性（GHS）

质量标准

质检证书（CoA,COO,BSE/TSE 和分析图谱)

相关产品

可替换产品

参考文献

溶液计算器

摩尔浓度计算器

稀释计算器

复溶计算器