计算溶液所需的质量、体积或浓度。
Elezanumab (anti-RGMA) (Ab175523) - SEC
The purity of Elezanumab (anti-RGMA) (Ab175523) is more than 95% verified by HPLC.
| 货号 (SKU) | 包装规格 | 是否现货 | 价格 | 数量 |
|---|---|---|---|---|
| Ab175523-100μg |
100μg |
现货 ![]() |
| |
| Ab175523-1mg |
1mg |
现货 ![]() |
| |
| Ab175523-5mg |
5mg |
现货 ![]() |
| |
| Ab175523-10mg |
10mg |
期货 ![]() |
|
| 产品名称 | Elezanumab (anti-RGMA), 排斥性引导分子 BMP 共受体 a 的抗体 |
|---|---|
| 别名 | 依来努单抗 |
| 英文别名 | Repulsive guidance molecule A antibody | RGM antibody | RGM domain family member A antibody | RGMA antibody | RGMA_HUMAN antibody | RGM domain family member A | RGM domain family, member A | RGMA | RGM-A | RGMrepulsive guidance molecule A | ABT-555 | AE12 |
| 规格或纯度 | 无载体, 重组, ExactAb™, 低内毒素, 无叠氮钠, 已验证, 无动物源, ≥95%(SDS-PAGE&SEC-HPLC), 见COA |
| 宿主种属 | 人(Human) |
| 特异性 | RGMA |
| 种属反应性 | 人(Human),大鼠(Rat),小鼠(Mouse),食蟹猴(Cynomolgus monkey) |
| 偶联 | Unconjugated |
| 作用类型 | 抑制剂 |
| 作用机制 | 排斥性引导分子 BMP 共受体 a 的抗体 |
| 克隆类型 | 重组抗体 |
|---|---|
| Format | Whole IgG |
| 亚型 | Human IgG1 |
| 轻链亚型 | lambda |
| SDS-PAGE | 28.5 kDa (Light Chain) & 50.7kDa (Heavy Chain), under reducing conditions; 196.5 kDa, under non-reducing conditions. |
| 纯化方法 | Protein A purified |
| 纯度 | >95% |
| 物理外观 | Liquid |
| 储存缓冲液 | Supplied as a 0.22μm filtered solution in 100mM Pro-Ac, 20mM Arg, pH 5.0 |
| 防腐剂 | No |
| 浓度 | 见COA |
| 储存温度 | -80℃储存,避免反复冻融 |
| 运输条件 | 超低温冰袋运输 |
| 稳定性与储存 | 在 -80℃ 下保存 24 个月。收货后建议分装。避免冷冻/解冻循环。 |
| CAS编号和信息 | 1791416-49-3 |
| 分子类型 | 抗体 |
Elezanumab (anti-RGMA) (Ab175523) - SEC
The purity of Elezanumab (anti-RGMA) (Ab175523) is more than 95% verified by HPLC.
| 作用机制 | Action Type | target ID | Target Name | Target Type | Target Organism | Binding Site Name | 参考文献 |
|---|
通过匹配包装上的批号来查找并下载产品的 COA,每批产品都进行了严格的验证,您可放心使用!
| 批号(Lot Number) | 证书类型 | 日期 | 货号 |
|---|---|---|---|
| 分析证书 | 24-05-31 | Ab175523 | |
| 分析证书 | 24-05-31 | Ab175523 | |
| 分析证书 | 24-05-31 | Ab175523 |
| 1. Demicheva E, Cui YF, Bardwell P, Barghorn S, Kron M, Meyer AH, Schmidt M, Gerlach B, Leddy M, Barlow E et al.. (2015) Targeting repulsive guidance molecule A to promote regeneration and neuroprotection in multiple sclerosis.. Cell Rep, 10 (11): (1887-98). [PMID:25801027] |
| 2. Wiemann, S S and 23 more authors.. (2001) Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs.. Genome research, [PMID:11230166] |
| 3. Zody, Michael C MC and 68 more authors.. (2006) Analysis of the DNA sequence and duplication history of human chromosome 15.. Nature, (30): [PMID:16572171] |
| 4. Hata, Katsuhiko K, Kaibuchi, Kozo K, Inagaki, Shinobu S and Yamashita, Toshihide T.. (2009) Unc5B associates with LARG to mediate the action of repulsive guidance molecule.. The Journal of cell biology, (9): [PMID:19273616] |
| 5. Endo, Mitsuharu M and Yamashita, Toshihide T.. (2009) Inactivation of Ras by p120GAP via focal adhesion kinase dephosphorylation mediates RGMa-induced growth cone collapse.. The Journal of neuroscience : the official journal of the Society for Neuroscience, (20): [PMID:19458235] |