| 货号 (SKU) | 包装规格 | 是否现货 | 价格 | 数量 |
|---|---|---|---|---|
| Ab175489-100μg |
100μg |
现货  |
| |
| Ab175489-1mg |
1mg |
现货 |
| |
| Ab175489-5mg |
5mg |
现货 |
| |
| Ab175489-10mg |
10mg |
期货 |
|
| 产品名称 | Catumaxomab (anti-CD3&EpCAM), CD3e 抗体 |
|---|---|
| 别名 | 卡妥索单抗 | CD3抗体 | CD3单克隆抗体 | CD3药靶抗体 | EpCAM抗体 | EpCAM单克隆抗体 | EpCAM药靶抗体 |
| 英文别名 | CD3 epsilon antibody | CD3e antibody | CD3e antigen antibody | CD3e antigen epsilon polypeptide (TiT3 complex) antibody | CD3E antigen epsilon polypeptide antibody | CD3E antigen, epsilon subunit antibody | CD3e molecule epsilon antibody | CD3e molecule, |
| 规格或纯度 | 无载体, 重组, ExactAb™, 低内毒素, 无叠氮钠, 已验证, 无动物源, ≥90%(SDS-PAGE&SEC-HPLC), 见COA |
| 生化机理 | CD3: The CD3 complex mediates signal transduction. EpCAM: May act as a physical homophilic interaction molecule between intestinal epithelial cells (IECs) and intraepithelial lymphocytes (IELs) at the mucosal epithelium for providing immunological barrier as a first line of defense against mucosal infection. Plays a role in embryonic stem cells proliferation and differentiation. Up-regulates the expression of FABP5, MYC and cyclins A and E. |
| 宿主种属 | Mouse; Rat |
| 特异性 | CD3E; EPCAM |
| 种属反应性 | 人(Human),大鼠(Rat),小鼠(Mouse) |
| 偶联 | Unconjugated |
| 作用类型 | 交联剂 |
| 作用机制 | CD3e 抗体 |
| 克隆类型 | 重组抗体 |
|---|---|
| Format | Whole IgG |
| 亚型 | Mouse IgG2a |
| 轻链亚型 | Mouse kappa & Rat lambda2b |
| SDS-PAGE | 146.73 kDa |
| 纯化方法 | Protein A purified |
| 储存缓冲液 | Supplied as a 0.22μm filtered solution in 100mM Pro-Ac, 20mM Arg, pH 5.0 |
| 防腐剂 | No |
| 浓度 | 见COA |
| 储存温度 | -80℃储存,避免反复冻融 |
| 运输条件 | 超低温冰袋运输 |
| 稳定性与储存 | 在 -80℃ 下保存 24 个月。收货后建议分装。避免冷冻/解冻循环。 |
| CAS编号和信息 | 509077-98-9 |
| 分子类型 | 抗体 |
Catumaxomab (anti-CD3&EpCAM) (Ab175489) - Flow Cytometry
Flow Cytometry analysis of Jurkat cells labelling CD3 (red) with Catumaxomab (anti-CD3&EpCAM) (Ab175489) at 1.0 μg/mL for 1 hour at 4°C. Goat Anti-Mouse IgG (PE) (Ab179006) at a dilution of 1/1000 was used as the secondary antibody. Blue - Isotype control, human IgG (Ab170213). Black - Unlabelled control, cells without incubation with primary antibody.
Catumaxomab (anti-CD3&EpCAM) (Ab175489) - ELISA
Immobilized Recombinant Human EpCAM protein (rp170132) at 1.0 μg/mL can bind Catumaxomab (anti-CD3&EpCAM) (Ab175489) with the EC₅₀ of 66.05 ng/mL.
Catumaxomab (anti-CD3&EpCAM) (Ab175489) - SEC
The purity of Catumaxomab (anti-CD3&EpCAM) (Ab175489) is more than 95% verified by HPLC.
| 作用机制 | Action Type | target ID | Target Name | Target Type | Target Organism | Binding Site Name | 参考文献 |
|---|
通过匹配包装上的批号来查找并下载产品的 COA，每批产品都进行了严格的验证，您可放心使用！
| 批号(Lot Number) | 证书类型 | 日期 | 货号 |
|---|---|---|---|
 ZJ25F0116597 |
分析证书 | 25-01-07 | Ab175489 |
| ZJ25F0116596 |
分析证书 | 25-01-07 | Ab175489 |
| ZJ25F0116595 |
分析证书 | 25-01-07 | Ab175489 |
| 1. Zeidler R, Reisbach G, Wollenberg B, Lang S, Chaubal S, Schmitt B, Lindhofer H. (1999) Simultaneous activation of T cells and accessory cells by a new class of intact bispecific antibody results in efficient tumor cell killing.. J Immunol, 163 (3): (1246-52). [PMID:10415020] |
| 2. Riesenberg R, Buchner A, Pohla H, Lindhofer H. (2001) Lysis of prostate carcinoma cells by trifunctional bispecific antibodies (alpha EpCAM x alpha CD3).. J Histochem Cytochem, 49 (7): (911-7). [PMID:11410615] |
| 3. Ruf P, Lindhofer H. (2001) Induction of a long-lasting antitumor immunity by a trifunctional bispecific antibody.. Blood, 98 (8): (2526-34). [PMID:11588051] |
| 4. Shen J, Zhu Z. (2008) Catumaxomab, a rat/murine hybrid trifunctional bispecific monoclonal antibody for the treatment of cancer.. Curr Opin Mol Ther, 10 (3): (273-84). [PMID:18535935] |
| 5. Sebastian M, Passlick B, Friccius-Quecke H, Jäger M, Lindhofer H, Kanniess F, Wiewrodt R, Thiel E, Buhl R, Schmittel A. (2007) Treatment of non-small cell lung cancer patients with the trifunctional monoclonal antibody catumaxomab (anti-EpCAM x anti-CD3): a phase I study.. Cancer Immunol Immunother, 56 (10): (1637-44). [PMID:17410361] |
| 6. Linke R, Klein A, Seimetz D. (2010) Catumaxomab: clinical development and future directions.. MAbs, 2 (2): (129-36). [PMID:20190561] |
| 7. Chelius D, Ruf P, Gruber P, Plöscher M, Liedtke R, Gansberger E, Hess J, Wasiliu M, Lindhofer H. (2010) Structural and functional characterization of the trifunctional antibody catumaxomab.. MAbs, 2 (3): (309-19). [PMID:20418662] |
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