产品名称	Efalizumab (anti-ITGAL), Integrin alpha-L/beta-2 (LFA-1) 抑制剂
别名	依法利珠单抗 \| 依法珠单抗 \| 依法利珠单抗 (抗 ITGAL)
英文别名	Lymphocyte function associated antigen, type 1, alpha subunit antibody \| Antigen CD11A (p180), lymphocyte function associated antigen 1, alpha polypeptide antibody \| Antigen CD11A antibody \| CD 11a antibody \| CD11 antigen-like family member A antibody \| C
规格或纯度	无载体, 重组, ExactAb™, 低内毒素, 无叠氮钠, 已验证, 无动物源, ≥95%(SDS-PAGE&SEC-HPLC), 见COA
宿主种属	人(Human)
特异性	ITGAL
种属反应性	人(Human),恒河猴(Rhesus monkey)
偶联	Unconjugated
作用类型	抑制剂
作用机制	Integrin alpha-L/beta-2 (LFA-1) 抑制剂

产品属性

克隆类型	重组抗体
Format	Whole IgG
亚型	Human IgG1
轻链亚型	kappa
SDS-PAGE	27.4 kDa (Light Chain) & 51.6 kDa (Heavy Chain), under reducing conditions; 176.6 kDa, under non-reducing conditions.
纯化方法	Protein A purified
纯度	>95%
物理外观	Liquid
储存缓冲液	Supplied as a 0.22 μm filtered solution in 100mM Pro-Ac, 20mM Arg, pH 5.0
防腐剂	No
浓度	见COA
储存温度	-80℃储存,避免反复冻融
运输条件	超低温冰袋运输
稳定性与储存	在 -80℃ 下保存 24 个月。收货后建议分装。避免冷冻/解冻循环。
CAS编号和信息	214745-43-4
分子类型	抗体

图片

Flow Cytometry: Efalizumab (anti-ITGAL) (Ab170884)

Efalizumab (anti-ITGAL) (Ab170884) - Flow Cytometry
Flow Cytometry analysis of human peripheral blood lymphocytes labelling ITGAL (red) with Efalizumab (anti-ITGAL) (Ab170884). Goat Anti-Human IgG (FITC) (Ab175834) at a dilution of 1/1000 was used as the secondary antibody. Blue - Isotype control, human IgG (Ab170213). Black - Unlabelled control, cells without incubation with primary antibody.

SEC: Efalizumab (anti-ITGAL) (Ab170884)

Efalizumab (anti-ITGAL) (Ab170884) - SEC
The purity of Efalizumab (anti-ITGAL) (Ab170884) is more than 95% verified by HPLC.

关联靶点（人）

ITGAL Tclin 整合素α-L(Integrin alpha-L) (0 活性数据)

点击查看靶蛋白信息： ITGAL

活性类型	活性值-log(M)	作用机制	期刊	参考文献(PubMed IDs)

ITGAL Tclin Leukocyte adhesion glycoprotein LFA-1 alpha (170 活性数据)

点击查看靶蛋白信息： ITGAL

活性类型	Relation	Activity value	Units	Action Type	期刊	PubMed Id	doi	Assay Aladdin ID

ITGAL Tclin Intercellular adhesion molecule (ICAM-1), Integrin alpha-L/beta-2 (760 活性数据)

点击查看靶蛋白信息： ITGAL

活性类型	Relation	Activity value	Units	Action Type	期刊	PubMed Id	doi	Assay Aladdin ID

作用机制

作用机制	Action Type	target ID	Target Name	Target Type	Target Organism	Binding Site Name	参考文献

安全和危险性（GHS）

SDS英文版

质量标准

质量标准

质检证书（CoA,COO,BSE/TSE 和分析图谱)

C of A & Other Certificates(BSE/TSE, COO):

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通过匹配包装上的批号来查找并下载产品的 COA，每批产品都进行了严格的验证，您可放心使用！

找到4个结果

批号(Lot Number)	证书类型	日期	货号
ZJ24F1012780	分析证书	24-10-24	Ab170884
ZJ24F1012779	分析证书	24-10-24	Ab170884
ZJ23F1001294	分析证书	23-10-13	Ab170884
ZJ23F1001295	分析证书	23-10-13	Ab170884

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参考文献

1. Burdick DJ, Paris K, Weese K, Stanley M, Beresini M, Clark K, McDowell RS, Marsters JC, Gadek TR.. (2003) N-Benzoyl amino acids as LFA-1/ICAM inhibitors 1: amino acid structure-activity relationship.. Bioorg Med Chem Lett, 13 (6): (1015-1018). [PMID:12643901] [10.1016/s0960-894x(03)00084-2]
2. Pei Z, Xin Z, Liu G, Li Y, Reilly EB, Lubbers NL, Huth JR, Link JT, von Geldern TW, Cox BF, Leitza S, Gao Y, Marsh KC, DeVries P, Okasinski GF.. (2001) Discovery of potent antagonists of leukocyte function-associated antigen-1/intercellular adhesion molecule-1 interaction. 3. Amide (C-ring) structure-activity relationship and improvement of overall properties of arylthio cinnamides.. J Med Chem, 44 (18): (2913-2920). [PMID:11520199] [10.1021/jm010059w]
3. Lin Kc, Ateeq HS, Hsiung SH, Chong LT, Zimmerman CN, Castro A, Lee WC, Hammond CE, Kalkunte S, Chen LL et al.. (1999) Selective, tight-binding inhibitors of integrin alpha4beta1 that inhibit allergic airway responses.. J Med Chem, 42 (5): (920-34). [PMID:10072689]
4. Yenari MA, Kunis D, Sun GH, Onley D, Watson L, Turner S, Whitaker S, Steinberg GK. (1998) Hu23F2G, an antibody recognizing the leukocyte CD11/CD18 integrin, reduces injury in a rabbit model of transient focal cerebral ischemia.. Exp Neurol, 153 (2): (223-33). [PMID:9784282]
5. Zhong M, Shen W, Barr KJ, Arbitrario JP, Arkin MR, Bui M, Chen T, Cunningham BC, Evanchik MJ, Hanan EJ, Hoch U, Huen K, Hyde J, Kumer JL, Lac T, Lawrence CE, Martell JR, Oslob JD, Paulvannan K, Prabhu S, Silverman JA, Wright J, Yu CH, Zhu J, Flanagan WM.. (2010) Discovery of tetrahydroisoquinoline (THIQ) derivatives as potent and orally bioavailable LFA-1/ICAM-1 antagonists.. Bioorg Med Chem Lett, 20 (17): (5269-5273). [PMID:20655213] [10.1016/j.bmcl.2010.06.145]
6. San Sebastián E, Zimmerman T, Zubia A, Vara Y, Martin E, Sirockin F, Dejaegere A, Stote RH, Lopez X, Pantoja-Uceda D, Valcárcel M, Mendoza L, Vidal-Vanaclocha F, Cossío FP, Blanco FJ.. (2013) Design, synthesis, and functional evaluation of leukocyte function associated antigen-1 antagonists in early and late stages of cancer development.. J Med Chem, 56 (3): (735-747). [PMID:23339734] [10.1021/jm3016848]
7. Larson, R S RS, Corbi, A L AL, Berman, L L and Springer, T T.. (1989) Primary structure of the leukocyte function-associated molecule-1 alpha subunit: an integrin with an embedded domain defining a protein superfamily.. The Journal of cell biology, [PMID:2537322]
8. Qu, A A and Leahy, D J DJ.. (1995) Crystal structure of the I-domain from the CD11a/CD18 (LFA-1, alpha L beta 2) integrin.. Proceedings of the National Academy of Sciences of the United States of America, (24): [PMID:7479767]
9. Cornwell, R D RD, Gollahon, K A KA and Hickstein, D D DD.. (1993) Description of the leukocyte function-associated antigen 1 (LFA-1 or CD11a) promoter.. Proceedings of the National Academy of Sciences of the United States of America, (1): [PMID:8097887]
10. Shelley, C S CS, Farokhzad, O C OC and Arnaout, M A MA.. (1993) Identification of cell-specific and developmentally regulated nuclear factors that direct myeloid and lymphoid expression of the CD11a gene.. Proceedings of the National Academy of Sciences of the United States of America, (1): [PMID:8099450]
11. Nueda, A A, López-Cabrera, M M, Vara, A A and Corbí, A L AL.. (1993) Characterization of the CD11a (alpha L, LFA-1 alpha) integrin gene promoter.. The Journal of biological chemistry, (15): [PMID:8103515]
12. Qu, A A and Leahy, D J DJ.. (1996) The role of the divalent cation in the structure of the I domain from the CD11a/CD18 integrin.. Structure (London, England : 1993), (15): [PMID:8805579]
13. Loftus, B J BJ and 18 more authors.. (1999) Genome duplications and other features in 12 Mb of DNA sequence from human chromosome 16p and 16q.. Genomics, (15): [PMID:10493829]
14. Kallen, J J and 8 more authors.. (1999) Structural basis for LFA-1 inhibition upon lovastatin binding to the CD11a I-domain.. Journal of molecular biology, (10): [PMID:10493852]
15. Weitz-Schmidt, G G and 8 more authors.. (2001) Statins selectively inhibit leukocyte function antigen-1 by binding to a novel regulatory integrin site.. Nature medicine, [PMID:11385505]
16. Ostermann, Georg G, Weber, Kim S C KS, Zernecke, Alma A, Schröder, Andreas A and Weber, Christian C.. (2002) JAM-1 is a ligand of the beta(2) integrin LFA-1 involved in transendothelial migration of leukocytes.. Nature immunology, [PMID:11812992]
17. Shimaoka, Motomu M and 11 more authors.. (2003) Structures of the alpha L I domain and its complex with ICAM-1 reveal a shape-shifting pathway for integrin regulation.. Cell, (10): [PMID:12526797]
18. Katano, Harutaka H, Pesnicak, Lesley L and Cohen, Jeffrey I JI.. (2004) Simvastatin induces apoptosis of Epstein-Barr virus (EBV)-transformed lymphoblastoid cell lines and delays development of EBV lymphomas.. Proceedings of the National Academy of Sciences of the United States of America, (6): [PMID:15041742]
19. Barber, Domingo F DF, Faure, Mathias M and Long, Eric O EO.. (2004) LFA-1 contributes an early signal for NK cell cytotoxicity.. Journal of immunology (Baltimore, Md. : 1950), (15): [PMID:15356110]
20. Martin, Joel J and 121 more authors.. (2004) The sequence and analysis of duplication-rich human chromosome 16.. Nature, (23): [PMID:15616553]
21. Wellington, Keri K and Perry, Caroline M CM.. (2005) Efalizumab.. American journal of clinical dermatology, [PMID:15799683]
22. Liao, James K JK and Laufs, Ulrich U.. (2005) Pleiotropic effects of statins.. Annual review of pharmacology and toxicology, [PMID:15822172]
23. Fagerholm, Susanna C SC, Hilden, Tiina J TJ, Nurmi, Susanna M SM and Gahmberg, Carl G CG.. (2005) Specific integrin alpha and beta chain phosphorylations regulate LFA-1 activation through affinity-dependent and -independent mechanisms.. The Journal of cell biology, (21): [PMID:16301335]
24. and Descamps, V V.. [Efalizumab].. Annales de dermatologie et de venereologie, [PMID:17053736]
25. Frampton, James E JE and Plosker, Greg L GL.. (2009) Efalizumab: a review of its use in the management of chronic moderate-to-severe plaque psoriasis.. American journal of clinical dermatology, [PMID:19170413]
26. Wollscheid, Bernd B and 7 more authors.. (2009) Mass-spectrometric identification and relative quantification of N-linked cell surface glycoproteins.. Nature biotechnology, [PMID:19349973]
27. Kristóf, Endre E and 5 more authors.. (2013) Novel role of ICAM3 and LFA-1 in the clearance of apoptotic neutrophils by human macrophages.. Apoptosis : an international journal on programmed cell death, [PMID:23775590]
28. Kawamoto, Eiji E and 6 more authors.. (2016) LFA-1 and Mac-1 integrins bind to the serine/threonine-rich domain of thrombomodulin.. Biochemical and biophysical research communications, (13): [PMID:27055590]
29. and Paton, D M DM.. (2016) Lifitegrast: First LFA-1/ICAM-1 antagonist for treatment of dry eye disease.. Drugs of today (Barcelona, Spain : 1998), [PMID:27883115]
30. Swaim, Caleb D CD, Scott, Ariella F AF, Canadeo, Larissa A LA and Huibregtse, Jon M JM.. (2017) Extracellular ISG15 Signals Cytokine Secretion through the LFA-1 Integrin Receptor.. Molecular cell, (2): [PMID:29100055]
31. Chen, X X, Ji, Z L ZL and Chen, Y Z YZ.. (2002) TTD: Therapeutic Target Database.. Nucleic acids research, (1): [PMID:11752352]

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Efalizumab (anti-ITGAL), Integrin alpha-L/beta-2 (LFA-1) 抑制剂

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基本信息

产品属性

图片

关联靶点（人）

作用机制

安全和危险性（GHS）

质量标准

质检证书（CoA,COO,BSE/TSE 和分析图谱)

相关产品

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参考文献

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