产品名称	Fresolimumab (anti-TGFb1), 转化生长因子 beta-1 抑制剂
别名	非苏木单抗 \| 费索木单抗（抗肿瘤坏死因子b1）
英文别名	Cartilage-inducing factor antibody \| CED antibody \| Differentiation inhibiting factor antibody \| DPD1 antibody \| LAP antibody \| Latency-associated peptide antibody \| Prepro transforming growth factor beta 1 antibody \| TGF beta 1 antibody \| TGF beta antibo
规格或纯度	无载体, 重组, ExactAb™, 低内毒素, 无叠氮钠, 已验证, 无动物源, ≥95%(SDS-PAGE&SEC-HPLC), 见COA
宿主种属	人(Human)
特异性	TGFB1
种属反应性	人(Human),小鼠(Mouse)
偶联	Unconjugated
作用类型	抑制剂
作用机制	转化生长因子 beta-1 抑制剂

产品属性

克隆类型	重组抗体
Format	Whole IgG
亚型	Human IgG4SP
轻链亚型	kappa
SDS-PAGE	26.9 kDa (Light Chain) & 51.6 kDa (Heavy Chain), under reducing conditions; 172.1 kDa, under non-reducing conditions.
纯化方法	Protein A purified
纯度	>95%
物理外观	Liquid
储存缓冲液	Supplied as a 0.22 μm filtered solution in 100mM Pro-Ac, 20mM Arg, pH 5.0
防腐剂	No
浓度	见COA
储存温度	-80℃储存,避免反复冻融
运输条件	超低温冰袋运输
稳定性与储存	在 -80℃ 下保存 24 个月。收货后建议分装。避免冷冻/解冻循环。
CAS编号和信息	948564-73-6
分子类型	抗体

图片

ELISA: Fresolimumab (anti-TGFb1) (Ab170872)

Fresolimumab (anti-TGFb1) (Ab170872) - ELISA
Immobilized Human Latent TGF-beta 1/TGFB1-his at 2.0 μg/mL can bind Fresolimumab (anti-TGFb1) (Ab170872) with the EC₅₀ of 60.47 ng/mL.

SEC: Fresolimumab (anti-TGFb1) (Ab170872)

Fresolimumab (anti-TGFb1) (Ab170872) - SEC
The purity of Fresolimumab (anti-TGFb1) (Ab170872) is more than 95% verified by HPLC.

关联靶点（人）

TGFB1 Tbio 转化生长因子β-1前蛋白(Transforming growth factor beta-1 proprotein) (0 活性数据)

点击查看靶蛋白信息： TGFB1

活性类型	活性值-log(M)	作用机制	期刊	参考文献(PubMed IDs)

TGFB1 Tbio Transforming growth factor beta-1 (34 活性数据)

点击查看靶蛋白信息： TGFB1

活性类型	Relation	Activity value	Units	Action Type	期刊	PubMed Id	doi	Assay Aladdin ID

作用机制

作用机制	Action Type	target ID	Target Name	Target Type	Target Organism	Binding Site Name	参考文献

安全和危险性（GHS）

SDS英文版

质量标准

质量标准

质检证书（CoA,COO,BSE/TSE 和分析图谱)

C of A & Other Certificates(BSE/TSE, COO):

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通过匹配包装上的批号来查找并下载产品的 COA，每批产品都进行了严格的验证，您可放心使用！

找到3个结果

批号(Lot Number)	证书类型	日期	货号
ZJ24F0303726	分析证书	24-03-26	Ab170872
ZJ24F0303725	分析证书	24-03-26	Ab170872
ZJ24F0303724	分析证书	24-03-26	Ab170872

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参考文献

1. Miyazono, K K, Olofsson, A A, Colosetti, P P and Heldin, C H CH.. (1991) A role of the latent TGF-beta 1-binding protein in the assembly and secretion of TGF-beta 1.. The EMBO journal, [PMID:2022183]
2. Massagué, J J and Like, B B.. (1985) Cellular receptors for type beta transforming growth factor. Ligand binding and affinity labeling in human and rodent cell lines.. The Journal of biological chemistry, (10): [PMID:2982829]
3. Miyazono, K K, Hellman, U U, Wernstedt, C C and Heldin, C H CH.. (1988) Latent high molecular weight complex of transforming growth factor beta 1. Purification from human platelets and structural characterization.. The Journal of biological chemistry, (5): [PMID:3162913]
4. Derynck, R R, Rhee, L L, Chen, E Y EY and Van Tilburg, A A.. (1987) Intron-exon structure of the human transforming growth factor-beta precursor gene.. Nucleic acids research, (10): [PMID:3470709]
5. Derynck, R R and 8 more authors.. (1985) Human transforming growth factor-beta complementary DNA sequence and expression in normal and transformed cells.. Nature, [PMID:3861940]
6. Dubois, C M CM, Laprise, M H MH, Blanchette, F F, Gentry, L E LE and Leduc, R R.. (1995) Processing of transforming growth factor beta 1 precursor by human furin convertase.. The Journal of biological chemistry, (5): [PMID:7737999]
7. Archer, S J SJ and 9 more authors.. (1993) Transforming growth factor beta 1: NMR signal assignments of the recombinant protein expressed and isotopically enriched using Chinese hamster ovary cells.. Biochemistry, (2): [PMID:8424942]
8. Archer, S J SJ and 9 more authors.. (1993) Transforming growth factor beta 1: secondary structure as determined by heteronuclear magnetic resonance spectroscopy.. Biochemistry, (2): [PMID:8424943]
9. Bourdrel, L L and 6 more authors.. (1993) Recombinant human transforming growth factor-beta 1: expression by Chinese hamster ovary cells, isolation, and characterization.. Protein expression and purification, [PMID:8471846]
10. Saharinen, J J, Taipale, J J and Keski-Oja, J J.. (1996) Association of the small latent transforming growth factor-beta with an eight cysteine repeat of its binding protein LTBP-1.. The EMBO journal, (15): [PMID:8617200]
11. Hinck, A P AP and 10 more authors.. (1996) Transforming growth factor beta 1: three-dimensional structure in solution and comparison with the X-ray structure of transforming growth factor beta 2.. Biochemistry, (2): [PMID:8679613]
12. Munger, J S JS and 5 more authors.. (1997) Latent transforming growth factor-beta: structural features and mechanisms of activation.. Kidney international, [PMID:9150447]
13. and Chang, N S NS.. (1997) Hyaluronidase enhancement of TNF-mediated cell death is reversed by TGF-beta 1.. The American journal of physiology, [PMID:9435505]
14. Yamada, Y Y and 9 more authors.. (1998) Association of a polymorphism of the transforming growth factor-beta1 gene with genetic susceptibility to osteoporosis in postmenopausal Japanese women.. Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research, [PMID:9783545]
15. and Chang, N S NS.. (1998) Transforming growth factor-beta protection of cancer cells against tumor necrosis factor cytotoxicity is counteracted by hyaluronidase (review).. International journal of molecular medicine, [PMID:9850732]
16. Okamoto, O O, Fujiwara, S S, Abe, M M and Sato, Y Y.. (1999) Dermatopontin interacts with transforming growth factor beta and enhances its biological activity.. The Biochemical journal, (1): [PMID:9895299]
17. Kinoshita, A A and 19 more authors.. (2000) Domain-specific mutations in TGFB1 result in Camurati-Engelmann disease.. Nature genetics, [PMID:10973241]
18. Janssens, K K and 10 more authors.. (2000) Mutations in the gene encoding the latency-associated peptide of TGF-beta 1 cause Camurati-Engelmann disease.. Nature genetics, [PMID:11062463]
19. and Chang, N S NS.. (2001) Hyaluronidase activation of c-Jun N-terminal kinase is necessary for protection of L929 fibrosarcoma cells from staurosporine-mediated cell death.. Biochemical and biophysical research communications, (4): [PMID:11327694]
20. Shur, I I, Lokiec, F F, Bleiberg, I I and Benayahu, D D.. (2001) Differential gene expression of cultured human osteoblasts.. Journal of cellular biochemistry, [PMID:11746498]
21. Watanabe, Yukio Y and 8 more authors.. (2002) A catalog of 106 single-nucleotide polymorphisms (SNPs) and 11 other types of variations in genes for transforming growth factor-beta1 (TGF-beta1) and its signaling pathway.. Journal of human genetics, [PMID:12202987]
22. Janssens, Katrien K, ten Dijke, Peter P, Ralston, Stuart H SH, Bergmann, Carsten C and Van Hul, Wim W.. (2003) Transforming growth factor-beta 1 mutations in Camurati-Engelmann disease lead to increased signaling by altering either activation or secretion of the mutant protein.. The Journal of biological chemistry, (28): [PMID:12493741]
23. McGowan, Neil W A NW and 7 more authors.. (2003) A mutation affecting the latency-associated peptide of TGFbeta1 in Camurati-Engelmann disease enhances osteoclast formation in vitro.. The Journal of clinical endocrinology and metabolism, [PMID:12843182]
24. Kinoshita, Akira A and 12 more authors.. (2004) TGFB1 mutations in four new families with Camurati-Engelmann disease: confirmation of independently arising LAP-domain-specific mutations.. American journal of medical genetics. Part A, (15): [PMID:15103729]
25. Lewandrowski, Urs U, Moebius, Jan J, Walter, Ulrich U and Sickmann, Albert A.. (2006) Elucidation of N-glycosylation sites on human platelet proteins: a glycoproteomic approach.. Molecular & cellular proteomics : MCP, [PMID:16263699]
26. Liu, Tao T and 6 more authors.. Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry.. Journal of proteome research, [PMID:16335952]
27. Finnson, Kenneth W KW and 7 more authors.. (2006) Identification of CD109 as part of the TGF-beta receptor system in human keratinocytes.. FASEB journal : official publication of the Federation of American Societies for Experimental Biology, [PMID:16754747]
28. Nakajima, Masahiro M and 5 more authors.. (2007) Mechanisms for asporin function and regulation in articular cartilage.. The Journal of biological chemistry, (2): [PMID:17827158]
29. Tran, Dat Q DQ and 5 more authors.. (2009) GARP (LRRC32) is essential for the surface expression of latent TGF-beta on platelets and activated FOXP3+ regulatory T cells.. Proceedings of the National Academy of Sciences of the United States of America, (11): [PMID:19651619]
30. Stockis, Julie J, Colau, Didier D, Coulie, Pierre G PG and Lucas, Sophie S.. (2009) Membrane protein GARP is a receptor for latent TGF-beta on the surface of activated human Treg.. European journal of immunology, [PMID:19750484]
31. Suzuki, Shigeki S and Kulkarni, Ashok B AB.. (2010) Extracellular heat shock protein HSP90beta secreted by MG63 osteosarcoma cells inhibits activation of latent TGF-beta1.. Biochemical and biophysical research communications, (30): [PMID:20599762]
32. Wang, Rui R and 5 more authors.. (2012) GARP regulates the bioavailability and activation of TGFβ.. Molecular biology of the cell, [PMID:22278742]
33. Papadopoulos, Georgios and 5 more authors.. (2013) Terazosin treatment induces caspase-3 expression in the rat ventral prostate.. Journal of clinical medicine research, [PMID:23518907]
34. Moulin, Aaron A and 18 more authors.. (2014) Structures of a pan-specific antagonist antibody complexed to different isoforms of TGFβ reveal structural plasticity of antibody-antigen interactions.. Protein science : a publication of the Protein Society, [PMID:25209176]
35. Chen, Qiuyue Q, Lee, Ching-En CE, Denard, Bray B and Ye, Jin J.. (2014) Sustained induction of collagen synthesis by TGF-β requires regulated intramembrane proteolysis of CREB3L1.. PloS one, [PMID:25310401]
36. Hwangbo, C C and 7 more authors.. (2016) Syntenin regulates TGF-β1-induced Smad activation and the epithelial-to-mesenchymal transition by inhibiting caveolin-mediated TGF-β type I receptor internalization.. Oncogene, (21): [PMID:25893292]
37. Sasaki, Takako T and 10 more authors.. (2016) Functional consequence of fibulin-4 missense mutations associated with vascular and skeletal abnormalities and cutis laxa.. Matrix biology : journal of the International Society for Matrix Biology, [PMID:27339457]
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39. Zhao, Bo B, Xu, Shutong S, Dong, Xianchi X, Lu, Chafen C and Springer, Timothy A TA.. (2018) Prodomain-growth factor swapping in the structure of pro-TGF-β1.. The Journal of biological chemistry, (2): [PMID:29109152]
40. Kotlarz, Daniel D and 23 more authors.. (2018) Human TGF-β1 deficiency causes severe inflammatory bowel disease and encephalopathy.. Nature genetics, [PMID:29483653]
41. Qin, Yan Y and 14 more authors.. (2018) A Milieu Molecule for TGF-β Required for Microglia Function in the Nervous System.. Cell, (28): [PMID:29909984]
42. Kim, June-Hyung; Ham, Sangwoo; Lee, Yunjong; Suh, Gee Young and Lee, Yun-Song.. (2019) TTC3 contributes to TGF-β1-induced epithelial-mesenchymal transition and myofibroblast differentiation, potentially through SMURF2 ubiquitylation and degradation.. Cell death & disease, (29): [PMID:30696809]

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Fresolimumab (anti-TGFb1), 转化生长因子 beta-1 抑制剂

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基本信息

产品属性

图片

关联靶点（人）

作用机制

安全和危险性（GHS）

质量标准

质检证书（CoA,COO,BSE/TSE 和分析图谱)

相关产品

可替换产品

参考文献

溶液计算器

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稀释计算器

复溶计算器