| 货号 (SKU) | 包装规格 | 是否现货 | 价格 | 数量 |
|---|---|---|---|---|
| Ab170726-100μg |
100μg |
现货  |
| |
| Ab170726-1mg |
1mg |
现货 |
| |
| Ab170726-5mg |
5mg |
现货 |
| |
| Ab170726-10mg |
10mg |
期货 |
|
| 产品名称 | Talquetamab (anti-GPRC5D), T 细胞表面糖蛋白的结合剂 CD3 结合剂 |
|---|---|
| 别名 | 他克他单抗(抗 GPRC5D) |
| 英文别名 | JNJ-64407564 | Talquetamab | G protein coupled receptor family C group 5 member D antibody | G-protein coupled receptor family C group 5 member D antibody | GPC5D_HUMAN antibody | GPRC5D antibody | G protein-coupled receptor, family C, group 5, member D | |
| 规格或纯度 | 无载体, 重组, ExactAb™, 低内毒素, 无叠氮钠, 已验证, 无动物源, ≥95%(SDS-PAGE&SEC-HPLC), 见COA |
| 宿主种属 | 人(Human) |
| 特异性 | GPRC5D |
| 应用 | ELISA,Functional Assay,Kinetics (BLI),Kinetics (SPR),Flow Cyt |
| 种属反应性 | 人(Human),小鼠(Mouse),食蟹猴(Cynomolgus monkey) |
| 偶联 | Unconjugated |
| 作用类型 | 结合剂 |
| 作用机制 | T 细胞表面糖蛋白的结合剂 CD3 结合剂 |
| 抗体类型 | Primary antibody |
|---|---|
| 克隆类型 | 重组抗体 |
| Format | Whole IgG |
| 亚型 | Human IgG4SP |
| 轻链亚型 | kappa |
| SDS-PAGE | 27.3 kDa (Light Chain) & 51.8 kDa (Heavy Chain), under reducing conditions; 176.9 kDa, under non-reducing conditions. |
| 纯化方法 | Protein A purified |
| 纯度 | >95% |
| 来源 | CHO supernatant |
| 物理外观 | Liquid |
| 储存缓冲液 | Supplied as a 0.22 μm filtered solution in 100mM Pro-Ac, 20mM Arg, pH 5.0 |
| 防腐剂 | No |
| 浓度 | 见COA |
| 储存温度 | -80℃储存,避免反复冻融 |
| 运输条件 | 超低温冰袋运输 |
| 稳定性与储存 | 在 -80℃ 下保存 24 个月。收货后建议分装。避免冷冻/解冻循环。 |
| CAS编号和信息 | 2226212-40-2 |
| 分子类型 | 抗体 |
Talquetamab (anti-GPRC5D) (Ab170726) - Flow Cytometry
Flow Cytometry analysis of Hela cells labelling GPRC5D (red) with Talquetamab (anti-GPRC5D) (Ab170726). Goat Anti-Human IgG (PE) (Ab175838) at a dilution of 1/1000 was used as the secondary antibody. Blue - Isotype control, human IgG (Ab170213). Black - Unlabelled control, cells without incubation with primary antibody.
Talquetamab (anti-GPRC5D) (Ab170726) - Flow Cytometry
Flow Cytometry analysis of Jurkat cells labelling GPRC5D (red) with Talquetamab (anti-GPRC5D) (Ab170726). Goat Anti-Human IgG (PE) (Ab175838) at a dilution of 1/1000 was used as the secondary antibody. Blue - Isotype control, human IgG (Ab170213). Black - Unlabelled control, cells without incubation with primary antibody.
| 作用机制 | Action Type | target ID | Target Name | Target Type | Target Organism | Binding Site Name | 参考文献 |
|---|
通过匹配包装上的批号来查找并下载产品的 COA，每批产品都进行了严格的验证，您可放心使用！
| 批号(Lot Number) | 证书类型 | 日期 | 货号 |
|---|---|---|---|
 ZJ24F0911484 |
分析证书 | 24-09-29 | Ab170726 |
| ZJ24F0911483 |
分析证书 | 24-09-29 | Ab170726 |
| ZJ24F0911482 |
分析证书 | 24-09-29 | Ab170726 |
| ZJ23F1101854 |
分析证书 | 23-11-29 | Ab170726 |
| ZJ23F1101853 |
分析证书 | 23-11-29 | Ab170726 |
| 1. Takeda S, Kadowaki S, Haga T, Takaesu H, Mitaku S. (2002) Identification of G protein-coupled receptor genes from the human genome sequence.. FEBS Lett, 520 (1-3): (97-101). [PMID:12044878] |
| 2. Bräuner-Osborne H, Jensen AA, Sheppard PO, Brodin B, Krogsgaard-Larsen P, O'Hara P. (2001) Cloning and characterization of a human orphan family C G-protein coupled receptor GPRC5D.. Biochim Biophys Acta, 1518 (237-248). [PMID:11311935] |
| 3. Pillarisetti K, Edavettal S, Mendonça M, Li Y, Tornetta M, Babich A, Majewski N, Husovsky M, Reeves D, Walsh E et al.. (2020) A T-cell-redirecting bispecific G-protein-coupled receptor class 5 member D x CD3 antibody to treat multiple myeloma.. Blood, 135 (15): (1232-1243). [PMID:32040549] |
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