Onartuzumab (anti-MET), MET 原癌基因抗体;受体酪氨酸激酶

    应用:
  • Animal Model
  • ELISA
  • Flow Cytometry
  • Functional Assay
功能和特点
  • 宿主种属: 人(Human)
  • 种属反应性: 人(Human), 小鼠(Mouse), 食蟹猴(Cynomolgus monkey)
  • 亚型: Human IgG1
  • 偶联: Unconjugated
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货号 (SKU) 包装规格 是否现货 价格 数量
Ab170687-100μg
100μg 现货 Stock Image
Ab170687-1mg
1mg 现货 Stock Image
Ab170687-5mg
5mg 现货 Stock Image
Ab170687-10mg
10mg 期货 Stock Image

基本信息

产品名称 Onartuzumab (anti-MET), MET 原癌基因抗体;受体酪氨酸激酶
别名 奥那妥组单抗 | 奥那珠单抗(抗 MET)
英文别名 Onartuzumab | MetMAb | Anti-HGFR / c-Met Reference Antibody (onartuzumab) | AUTS9 antibody | c met antibody | D249 antibody | Hepatocyte growth factor receptor antibody | HGF antibody | HGF receptor antibody | HGF/SF receptor antibody | HGFR antibody | ME
规格或纯度 无载体, 重组, ExactAb™, 低内毒素, 无叠氮钠, 已验证, 无动物源, ≥95%(SDS-PAGE&SEC-HPLC), 见COA
宿主种属 人(Human)
特异性 MET
应用 ELISA,Functional Assay,Flow cytometry,Kinetics (BLI),Kinetics (SPR)
种属反应性 人(Human),小鼠(Mouse),食蟹猴(Cynomolgus monkey)
偶联 Unconjugated
作用类型 拮抗剂
作用机制 MET 原癌基因抗体;受体酪氨酸激酶

产品属性

抗体类型 Primary antibody
克隆类型 重组抗体
Format Whole IgG
亚型 Human IgG1
轻链亚型 kappa
SDS-PAGE 99.15 kDa
纯化方法 Protein A purified
纯度 >95%
来源 CHO supernatant
物理外观 Liquid
储存缓冲液 Supplied as a 0.22 μm filtered solution in 100mM Pro-Ac, 20mM Arg, pH 5.0
防腐剂 No
浓度 见COA
储存温度 -80℃储存,避免反复冻融
运输条件 超低温冰袋运输
稳定性与储存 在 -80℃ 下保存 24 个月。收货后建议分装。避免冷冻/解冻循环。
CAS编号和信息 1133766-06-9
分子类型 抗体

图片

Onartuzumab (anti-MET) (Ab170687) - Flow Cytometry
Flow Cytometry analysis of Jurkat cells labelling MET (red) with Onartuzumab (anti-MET) (Ab170687). Goat Anti-Human IgG (PE) (Ab175838) at a dilution of 1/1000 was used as the secondary antibody. Blue - Isotype control, human IgG (Ab170213). Black - Unlabelled control, cells without incubation with primary antibody.

Onartuzumab (anti-MET) (Ab170687) - SEC
The purity of Onartuzumab (anti-MET) (Ab170687) is more than 95% verified by HPLC.

关联靶点(人)

MET Tclin 肝细胞生长因子受体(Hepatocyte growth factor receptor) (0 活性数据)
活性类型 活性值-log(M) 作用机制 期刊 参考文献(PubMed IDs)

作用机制

作用机制 Action Type target ID Target Name Target Type Target Organism Binding Site Name 参考文献

安全和危险性(GHS)

质量标准

质检证书(CoA,COO,BSE/TSE 和分析图谱)

C of A & Other Certificates(BSE/TSE, COO):
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找到5个结果

批号(Lot Number) 证书类型 日期 货号
ZJ24F0911265 分析证书 24-09-26 Ab170687
ZJ24F0911266 分析证书 24-09-26 Ab170687
ZJ24F0911267 分析证书 24-09-26 Ab170687
ZJ23F1001505 分析证书 23-11-02 Ab170687
ZJ23F1001506 分析证书 23-11-02 Ab170687

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参考文献

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192. Campbell, Daniel B DB and 11 more authors..  (2006)  A genetic variant that disrupts MET transcription is associated with autism..  Proceedings of the National Academy of Sciences of the United States of America,  (7): [PMID:17053076]
193. Niemann, Hartmut H HH and 7 more authors..  (2007)  Structure of the human receptor tyrosine kinase met in complex with the Listeria invasion protein InlB..  Cell,  (27): [PMID:17662939]
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206. Tode, Naoki N and 18 more authors..  (2017)  Exome sequencing deciphers a germline MET mutation in familial epidermal growth factor receptor-mutant lung cancer..  Cancer science,  [PMID:28294470]
207. Cavaliere, Alessandra and 7 more authors..  (2021)  Development of [89Zr]ZrDFO-amivantamab bispecific to EGFR and c-MET for PET imaging of triple-negative breast cancer..  European journal of nuclear medicine and molecular imaging,  [PMID:32770372]
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