| 货号 (SKU) | 包装规格 | 是否现货 | 价格 | 数量 |
|---|---|---|---|---|
| Ab170685-100μg |
100μg |
现货  |
| |
| Ab170685-1mg |
1mg |
现货 |
| |
| Ab170685-5mg |
5mg |
现货 |
| |
| Ab170685-10mg |
10mg |
期货 |
|
| 产品名称 | Onvatilimab (anti-VISTA) |
|---|---|
| 别名 | 奥瓦利单抗 | 抗VISTA单克隆抗体 |
| 英文别名 | Anti-B7-H5 / VISTA Reference Antibody (onvatilimab) | Onvatilimab | JNJ-61610588 | B7 H5 antibody | B7H5 antibody | C10orf54 antibody | chromosome 10 open reading frame 54 antibody | DD1alpha antibody | GI24 antibody | GI24_HUMAN antibody | PD-1H antibody |
| 规格或纯度 | 无载体, 重组, ExactAb™, 低内毒素, 无叠氮钠, 已验证, 无动物源, ≥95%(SDS-PAGE&SEC-HPLC), 见COA |
| 宿主种属 | 人(Human) |
| 特异性 | VSIR |
| 应用 | ELISA,Functional Assay,Flow cytometry,Kinetics (BLI),Kinetics (SPR) |
| 种属反应性 | 人(Human),小鼠(Mouse),食蟹猴(Cynomolgus monkey) |
| 偶联 | Unconjugated |
| 抗体类型 | Primary antibody |
|---|---|
| 克隆类型 | 重组抗体 |
| Format | Whole IgG |
| 亚型 | Human IgG1 |
| 轻链亚型 | kappa |
| SDS-PAGE | 26.7 kDa (Light Chain) & 51.4 kDa (Heavy Chain), under reducing conditions; 166.8 kDa, under non-reducing conditions. |
| 纯化方法 | Protein A purified |
| 纯度 | >95% |
| 来源 | CHO supernatant |
| 物理外观 | Liquid |
| 储存缓冲液 | Supplied as a 0.22 μm filtered solution in 100mM Pro-AC, 20mM Arg, pH 5.0 |
| 防腐剂 | No |
| 浓度 | 见COA |
| 储存温度 | -80℃储存,避免反复冻融 |
| 运输条件 | 超低温冰袋运输 |
| 稳定性与储存 | 在 -80℃ 下保存 24 个月。收货后建议分装。避免冷冻/解冻循环。 |
| CAS编号和信息 | 1969313-51-6 |
| 分子类型 | 抗体 |
Onvatilimab (anti-VISTA) (Ab170685) - Flow Cytometry
Flow Cytometry analysis of Jurkat cells labelling VISTA (red) with Onvatilimab (anti-VISTA) (Ab170685). Goat Anti-Human IgG (PE) (Ab175838) at a dilution of 1/1000 was used as the secondary antibody. Blue - Isotype control, human IgG (Ab170213). Black - Unlabelled control, cells without incubation with primary antibody.
Onvatilimab (anti-VISTA) (Ab170685) - Flow Cytometry
Flow Cytometry analysis of Jurkat cells labelling VISTA (red) with Onvatilimab (anti-VISTA) (Ab170685). Goat Anti-Human IgG (PE) (Ab175838) at a dilution of 1/1000 was used as the secondary antibody. Blue - Isotype control, human IgG (Ab170213). Black - Unlabelled control, cells without incubation with primary antibody.
| 作用机制 | Action Type | target ID | Target Name | Target Type | Target Organism | Binding Site Name | 参考文献 |
|---|
通过匹配包装上的批号来查找并下载产品的 COA，每批产品都进行了严格的验证，您可放心使用！
| 批号(Lot Number) | 证书类型 | 日期 | 货号 |
|---|---|---|---|
 ZJ24F0911424 |
分析证书 | 24-09-29 | Ab170685 |
| ZJ24F0911425 |
分析证书 | 24-09-29 | Ab170685 |
| ZJ24F0911426 |
分析证书 | 24-09-29 | Ab170685 |
| ZJ23F1101560 |
分析证书 | 23-11-08 | Ab170685 |
| ZJ23F1101561 |
分析证书 | 23-11-08 | Ab170685 |
| 1. Deloukas, P P and 135 more authors.. (2004) The DNA sequence and comparative analysis of human chromosome 10.. Nature, (27): [PMID:15164054] |
| 2. Wan, Dafang D and 24 more authors.. (2004) Large-scale cDNA transfection screening for genes related to cancer development and progression.. Proceedings of the National Academy of Sciences of the United States of America, (2): [PMID:15498874] |
| 3. Sakr, Moustafa A MA and 7 more authors.. (2010) GI24 enhances tumor invasiveness by regulating cell surface membrane-type 1 matrix metalloproteinase.. Cancer science, [PMID:20666777] |
| 4. Lines, J Louise JL and 10 more authors.. (2014) VISTA is an immune checkpoint molecule for human T cells.. Cancer research, (1): [PMID:24691993] |
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