| 货号 (SKU) | 包装规格 | 是否现货 | 价格 | 数量 |
|---|---|---|---|---|
| Ab170644-100μg |
100μg |
现货  |
| |
| Ab170644-1mg |
1mg |
现货 |
| |
| Ab170644-5mg |
5mg |
现货 |
| |
| Ab170644-10mg |
10mg |
期货 |
|
| 产品名称 | Zilovertamab (anti-ROR1) |
|---|---|
| 别名 | 泽罗妥单抗 | 齐洛韦坦单抗（抗 ROR1） |
| 英文别名 | DJ537F10.1 antibody | Inactive tyrosine protein kinase transmembrane receptor ROR1 antibody | MGC99659 antibody | Neurotrophic tyrosine kinase antibody | Neurotrophic tyrosine kinase receptor related 1 antibody | Neurotrophic tyrosine kinase, receptor rel |
| 规格或纯度 | 无载体, 重组, ExactAb™, 低内毒素, 无叠氮钠, 已验证, 无动物源, ≥95%(SDS-PAGE&SEC-HPLC), 见COA |
| 宿主种属 | 人(Human) |
| 特异性 | ROR1 |
| 应用 | ELISA,Functional Assay,Flow cytometry,Kinetics (BLI),Kinetics (SPR) |
| 种属反应性 | 人(Human) |
| 偶联 | Unconjugated |
| 抗体类型 | Primary antibody |
|---|---|
| 克隆类型 | 重组抗体 |
| Format | Whole IgG |
| 亚型 | Human IgG1 |
| 轻链亚型 | kappa |
| SDS-PAGE | 28.2 kDa (Light Chain) & 52.5 kDa (Heavy Chain), under reducing conditions; 175.8 kDa, under non-reducing conditions. |
| 纯化方法 | Protein A purified |
| 纯度 | >95% |
| 来源 | CHO supernatant |
| 物理外观 | Liquid |
| 储存缓冲液 | Supplied as a 0.22 μm filtered solution in 100mM Pro-Ac, 20mM Arg, pH 5.0 |
| 防腐剂 | No |
| 浓度 | 见COA |
| 储存温度 | -80℃储存,避免反复冻融 |
| 运输条件 | 超低温冰袋运输 |
| 稳定性与储存 | 在 -80℃ 下保存 24 个月。收货后建议分装。避免冷冻/解冻循环。 |
| CAS编号和信息 | 2485779-13-1 |
| 分子类型 | 抗体 |
Zilovertamab (anti-ROR1) (Ab170644) - Flow Cytometry
Flow Cytometry analysis of MDA-MB-231 cells labelling ROR1 (red) with Zilovertamab (anti-ROR1) (Ab170644). Goat Anti-Human IgG (PE) (Ab175838) at a dilution of 1/1000 was used as the secondary antibody. Blue - Isotype control, human IgG (Ab170213). Black - Unlabelled control, cells without incubation with primary antibody.
Zilovertamab (anti-ROR1) (Ab170644) - SEC
The purity of Zilovertamab (anti-ROR1) (Ab170644) is more than 95% verified by HPLC.
Zilovertamab (anti-ROR1) (Ab170644) - ELISA
Immobilized huROR1-ECD-his at 2 μg/mL can bind Zilovertamab (anti-ROR1) (Ab170644) with the EC₅₀ of 3.08 ng/mL.
| 作用机制 | Action Type | target ID | Target Name | Target Type | Target Organism | Binding Site Name | 参考文献 |
|---|
通过匹配包装上的批号来查找并下载产品的 COA，每批产品都进行了严格的验证，您可放心使用！
| 批号(Lot Number) | 证书类型 | 日期 | 货号 |
|---|---|---|---|
 ZJ24F1012773 |
分析证书 | 24-10-23 | Ab170644 |
| ZJ24F1012765 |
分析证书 | 24-10-23 | Ab170644 |
| ZJ23F0901025 |
分析证书 | 23-09-14 | Ab170644 |
| ZJ23F0901027 |
分析证书 | 23-09-14 | Ab170644 |
| 1. Masiakowski, P P and Carroll, R D RD.. (1992) A novel family of cell surface receptors with tyrosine kinase-like domain.. The Journal of biological chemistry, (25): [PMID:1334494] |
| 2. Reddy, U R UR, Phatak, S S and Pleasure, D D.. (1996) Human neural tissues express a truncated Ror1 receptor tyrosine kinase, lacking both extracellular and transmembrane domains.. Oncogene, (3): [PMID:8875995] |
| 3. Bainbridge, Travis W TW and 15 more authors.. (2014) Evolutionary divergence in the catalytic activity of the CAM-1, ROR1 and ROR2 kinase domains.. PloS one, [PMID:25029443] |
| 4. Diaz-Horta, Oscar O and 20 more authors.. (2016) ROR1 is essential for proper innervation of auditory hair cells and hearing in humans and mice.. Proceedings of the National Academy of Sciences of the United States of America, (24): [PMID:27162350] |
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