Mavrilimumab (anti-CD116), GM-CSF 受体 α 亚基抗体

    应用:
  • Animal Model
  • ELISA
  • Flow Cytometry
  • Functional Assay
功能和特点
  • 宿主种属: 人(Human)
  • 种属反应性: 人(Human), 食蟹猴(Cynomolgus monkey)
  • 亚型: Human IgG4SP
  • 偶联: Unconjugated
有货

库存信息

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库存信息

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库存信息

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库存信息

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货号 (SKU) 包装规格 是否现货 价格 数量
Ab170528-100μg
100μg 现货 Stock Image
Ab170528-1mg
1mg 现货 Stock Image
Ab170528-5mg
5mg 现货 Stock Image
Ab170528-10mg
10mg 期货 Stock Image

基本信息

产品名称 Mavrilimumab (anti-CD116), GM-CSF 受体 α 亚基抗体
别名 玛弗利木单抗 | 马瑞利姆单抗(抗 CD116)
英文别名 CD116 antigen | CD116 | CDw116 | colony stimulating factor 2 receptor alpha subunit | colony stimulating factor 2 receptor, alpha, low-affinity(granulocyte-macrophage) | CSF2R | CSF2RA | CSF2RAX | CSF2RAY | CSF2RX | CSF2RY | GM-CSF R alpha | GM-CSF recept
规格或纯度 无载体, 重组, ExactAb™, 低内毒素, 无叠氮钠, 已验证, 无动物源, ≥95%(SDS-PAGE&SEC-HPLC), 见COA
宿主种属 人(Human)
特异性 CD116
应用 ELISA,Functional Assay,Flow cytometry,Kinetics (BLI),Kinetics (SPR)
种属反应性 人(Human),食蟹猴(Cynomolgus monkey)
偶联 Unconjugated
作用类型 拮抗剂
作用机制 GM-CSF 受体 α 亚基抗体

产品属性

抗体类型 Primary antibody
克隆类型 重组抗体
Format Whole IgG
亚型 Human IgG4SP
轻链亚型 lambdaC2
SDS-PAGE 28.7 kDa (Light Chain) & 52.9 kDa (Heavy Chain), under reducing conditions; 165.8 kDa, under non-reducing conditions.
纯化方法 Protein A purified
纯度 >95%
来源 CHO supernatant
物理外观 Liquid
储存缓冲液 Supplied as a 0.22 μm filtered solution in 100mM Pro-Ac, 20mM Arg, pH 5.0
防腐剂 No
浓度 见COA
储存温度 -80℃储存,避免反复冻融
运输条件 超低温冰袋运输
稳定性与储存 在 -80℃ 下保存 24 个月。收货后建议分装。避免冷冻/解冻循环。
CAS编号和信息 1085337-57-0
分子类型 抗体

图片

Mavrilimumab (anti-CD116) (Ab170528) - Flow Cytometry
Flow Cytometry analysis of U937 cells labelling CD116 (red) with Mavrilimumab (anti-CD116) (Ab170528). Goat Anti-Human IgG (PE) (Ab175838) at a dilution of 1/1000 was used as the secondary antibody. Blue - Isotype control, human IgG4SP. Black - Unlabelled control, cells without incubation with primary antibody.

Mavrilimumab (anti-CD116) (Ab170528) - SEC
The purity of Mavrilimumab (anti-CD116) (Ab170528) is more than 95% verified by HPLC.

关联靶点(人)

CSF2RA Tclin 粒细胞-巨噬细胞集落刺激因子受体亚单位α(Granulocyte-macrophage colony-stimulating factor receptor subunit alpha) (0 活性数据)
活性类型 活性值-log(M) 作用机制 期刊 参考文献(PubMed IDs)

作用机制

作用机制 Action Type target ID Target Name Target Type Target Organism Binding Site Name 参考文献

安全和危险性(GHS)

质量标准

质检证书(CoA,COO,BSE/TSE 和分析图谱)

C of A & Other Certificates(BSE/TSE, COO):
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找到4个结果

批号(Lot Number) 证书类型 日期 货号
ZJ24F1012677 分析证书 24-10-23 Ab170528
ZJ24F1012768 分析证书 24-10-23 Ab170528
ZJ23F0900982 分析证书 23-09-06 Ab170528
ZJ23F0900985 分析证书 23-09-06 Ab170528

参考文献

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12. Chen, Jian J, Cárcamo, Juan M JM and Golde, David W DW..  (2006)  The alpha subunit of the granulocyte-macrophage colony-stimulating factor receptor interacts with c-Kit and inhibits c-Kit signaling..  The Journal of biological chemistry,  (4): [PMID:16760463]
13. Wang, Ying Y and 8 more authors..  (2007)  Adaptive secretion of granulocyte-macrophage colony-stimulating factor (GM-CSF) mediates imatinib and nilotinib resistance in BCR/ABL+ progenitors via JAK-2/STAT-5 pathway activation..  Blood,  (1): [PMID:17090651]
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