产品名称	CD18 Mouse mAb
别名	整合素β2(CD18)单克隆抗体 \| CD18抗体 \| CD18小鼠单克隆抗体 \| CD18小鼠单抗
英文别名	Cell surface adhesion glycoproteins LFA-1/CR3/p150,95 subunit beta \| Complement receptor C3 subunit beta \| CD18 \| LAD \| LCAMB \| LFA-1 \| MAC-1 \| MF17 \| MFI7 \| 959 beta subunit precursor)10 \| CD18 antigen \| CD18beta 2 \| cell surface adhesion glycoprotein (L
规格或纯度	无载体, ExactAb™, 已验证, 见COA
宿主种属	小鼠(Mouse)
特异性	CD18
种属反应性	人(Human)
免疫原	Human tonsil cells
阳性对照	Flow: Human peripheral blood lymphocytes.
偶联	Unconjugated

产品属性

克隆类型	单克隆抗体
克隆号	HI18a
Format	Whole IgG
亚型	Mouse IgG1
轻链亚型	kappa
SDS-PAGE	150 kDa
纯化方法	Protein A purified
物理外观	Liquid
储存缓冲液	10mM PBS, 0.1% Sodium azide, pH 7.2
防腐剂	0.1% Sodium azide
浓度	见COA
储存温度	2-8°C储存
运输条件	冰袋运输
稳定性与储存	4°C 下运输。4°C 长期保存（36 个月）。收货后建议分装。
分子类型	抗体

图片

Flow Cytometry: CD18 Mouse mAb (Ab094074)

CD18 Mouse mAb (Ab094074) - Flow Cytometry
Flow Cytometry analysis of U937 cells labelling CD18 (red) with CD18 Mouse mAb (Ab094074) at 0.05 μg/mL for 1 hour at 4°C. Goat Anti-Mouse IgG (PE) (Ab179006) at a dilution of 1/1000 was used as the secondary antibody. Blue - Isotype control, mouse IgG (Ab170221). Black - Unlabelled control, cells without incubation with primary antibody.

Flow Cytometry: CD18 Mouse mAb (Ab094074)

CD18 Mouse mAb (Ab094074) - Flow Cytometry
Flow Cytometry analysis of Jurkat cells labelling CD18 (red) with CD18 Mouse mAb (Ab094074) at 0.5 μg/mL for 1 hour at 4°C. Goat Anti-Mouse IgG (PE) (Ab179006) at a dilution of 1/1000 was used as the secondary antibody. Blue - Isotype control, mouse IgG (Ab170221). Black - Unlabelled control, cells without incubation with primary antibody.

关联靶点（人）

ITGB2 Tclin 整合素β-2(Integrin beta-2) (0 活性数据)

点击查看靶蛋白信息： ITGB2

活性类型	活性值-log(M)	作用机制	期刊	参考文献(PubMed IDs)

ITGB2 Tclin Integrin beta-2 (0 活性数据)

点击查看靶蛋白信息： ITGB2

活性类型	Relation	Activity value	Units	Action Type	期刊	PubMed Id	doi	Assay Aladdin ID

ITGB2 Tclin Integrin alpha-M/beta-2 (32 活性数据)

点击查看靶蛋白信息： ITGB2

活性类型	Relation	Activity value	Units	Action Type	期刊	PubMed Id	doi	Assay Aladdin ID

作用机制

作用机制	Action Type	target ID	Target Name	Target Type	Target Organism	Binding Site Name	参考文献

安全和危险性（GHS）

SDS英文版

质量标准

质量标准

应用

应用名称	稀释比例
Flow Cytometry	< 0.5µg/100w cells

质检证书（CoA,COO,BSE/TSE 和分析图谱)

C of A & Other Certificates(BSE/TSE, COO):

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找到3个结果

批号(Lot Number)	证书类型	日期	货号
ZJ24F0505958	分析证书	24-05-22	Ab094074
ZJ24F0505959	分析证书	24-05-22	Ab094074
ZJ24F0505960	分析证书	24-05-22	Ab094074

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参考文献

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4. Yenari MA, Kunis D, Sun GH, Onley D, Watson L, Turner S, Whitaker S, Steinberg GK. (1998) Hu23F2G, an antibody recognizing the leukocyte CD11/CD18 integrin, reduces injury in a rabbit model of transient focal cerebral ischemia.. Exp Neurol, 153 (2): (223-33). [PMID:9784282]
5. Faridi MH, Maiguel D, Barth CJ, Stoub D, Day R, Schürer S, Gupta V.. (2009) Identification of novel agonists of the integrin CD11b/CD18.. Bioorg Med Chem Lett, 19 (24): (6902-6906). [PMID:19879752] [10.1016/j.bmcl.2009.10.077]
6. Zhong M, Shen W, Barr KJ, Arbitrario JP, Arkin MR, Bui M, Chen T, Cunningham BC, Evanchik MJ, Hanan EJ, Hoch U, Huen K, Hyde J, Kumer JL, Lac T, Lawrence CE, Martell JR, Oslob JD, Paulvannan K, Prabhu S, Silverman JA, Wright J, Yu CH, Zhu J, Flanagan WM.. (2010) Discovery of tetrahydroisoquinoline (THIQ) derivatives as potent and orally bioavailable LFA-1/ICAM-1 antagonists.. Bioorg Med Chem Lett, 20 (17): (5269-5273). [PMID:20655213] [10.1016/j.bmcl.2010.06.145]
7. Chen J, Song Y, Bojadzic D, Tamayo-Garcia A, Landin AM, Blomberg BB, Buchwald P.. (2017) Small-Molecule Inhibitors of the CD40-CD40L Costimulatory Protein-Protein Interaction.. J Med Chem, 60 (21): (8906-8922). [PMID:29024591] [10.1021/acs.jmedchem.7b01154]
8. Nelson, C C, Rabb, H H and Arnaout, M A MA.. (1992) Genetic cause of leukocyte adhesion molecule deficiency. Abnormal splicing and a missense mutation in a conserved region of CD18 impair cell surface expression of beta 2 integrins.. The Journal of biological chemistry, (15): [PMID:1346613]
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21. Hattori, M M and 64 more authors.. (2000) The DNA sequence of human chromosome 21.. Nature, (18): [PMID:10830953]
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24. Denti, Simona S and 8 more authors.. (2004) RanBPM is a phosphoprotein that associates with the plasma membrane and interacts with the integrin LFA-1.. The Journal of biological chemistry, (26): [PMID:14722085]
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26. Fagerholm, Susanna C SC, Hilden, Tiina J TJ, Nurmi, Susanna M SM and Gahmberg, Carl G CG.. (2005) Specific integrin alpha and beta chain phosphorylations regulate LFA-1 activation through affinity-dependent and -independent mechanisms.. The Journal of cell biology, (21): [PMID:16301335]
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33. Parvaneh, Nima N and 12 more authors.. (2010) Characterization of 11 new cases of leukocyte adhesion deficiency type 1 with seven novel mutations in the ITGB2 gene.. Journal of clinical immunology, [PMID:20549317]
34. Jerke, Uwe U and 7 more authors.. (2011) Complement receptor Mac-1 is an adaptor for NB1 (CD177)-mediated PR3-ANCA neutrophil activation.. The Journal of biological chemistry, (4): [PMID:21193407]
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37. Bai, Ming M and 13 more authors.. (2017) CD177 modulates human neutrophil migration through activation-mediated integrin and chemoreceptor regulation.. Blood, (9): [PMID:28807980]
38. Swaim, Caleb D CD, Scott, Ariella F AF, Canadeo, Larissa A LA and Huibregtse, Jon M JM.. (2017) Extracellular ISG15 Signals Cytokine Secretion through the LFA-1 Integrin Receptor.. Molecular cell, (2): [PMID:29100055]

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体积（添加到小瓶中）

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所需的复溶浓度

CD18 Mouse mAb

库存信息

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库存信息

库存信息

基本信息

产品属性

图片

关联靶点（人）

作用机制

安全和危险性（GHS）

质量标准

应用

质检证书（CoA,COO,BSE/TSE 和分析图谱)

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参考文献

溶液计算器

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