beta III Tubulin Mouse mAb

无载体

已验证

ExactAb™

高性能

见COA

应用:

功能和特点

宿主种属: 小鼠(Mouse)
种属反应性: 人(Human), 大鼠(Rat), 小鼠(Mouse)
亚型: Mouse IgG
克隆号: CHSMIX
偶联: Unconjugated

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货号 (SKU)	包装规格	是否现货
Ab091155-10μl	10μl	现货
Ab091155-50μl	50μL	现货
Ab091155-100μl	100μL	期货
Ab091155-1ml	1ml	期货

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点击查看靶蛋白信息: TUBB3

Accession#:Q13509 (6) beta III Tubulin (6) Gene ID:10381 (6) Loading control (34) TUBB3 (6)

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基本信息

产品名称	beta III Tubulin Mouse mAb
别名	微管蛋白β3抗体 \| 微管蛋白β3内参抗体 \| 微管蛋白β3抗体 \| 微管蛋白β3内参抗体 \| beta III 微管蛋白小鼠单克隆抗体 \| beta III 微管蛋白小鼠单抗
英文别名	beta 3 tubulin antibody \| beta 4 antibody \| beta-4 antibody \| CDCBM antibody \| CDCBM1 antibody \| CFEOM3 antibody \| CFEOM3A antibody \| FEOM3 antibody \| M(beta)3 antibody \| M(beta)6 antibody \| MC1R antibody \| Neuron specific beta III Tubulin antibody \| Neur
规格或纯度	无载体, ExactAb™, 已验证, 高性能, 见COA
生化机理	Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha-chain. TUBB3 plays a critical role in proper axon guidance and mantainance. Post-translational: Some glutamate residues at the C-terminus are polyglutamylated. This modification occurs exclusively on glutamate residues and results in polyglutamate chains on the gamma-carboxyl group. Also monoglycylated but not polyglycylated due to the absence of functional TTLL10 in human. Monoglycylation is mainly limited to tubulin incorporated into axonemes (cilia and flagella) whereas glutamylation is prevalent in neuronal cells, centrioles, axonemes, and the mitotic spindle. Both modifications can coexist on the same protein on adjacent residues, and lowering glycylation levels increases polyglutamylation, and reciprocally. The precise function of such modifications is still unclear but they regulate the assembly and dynamics of axonemal microtubules.
宿主种属	小鼠(Mouse)
特异性	TUBB3
种属反应性	人(Human),大鼠(Rat),小鼠(Mouse)
免疫原	A synthetic peptide derived from human Beta3-tubulin.
阳性对照	WB: Mouse brain, HeLa, SK-N-SH, Hep G2, NIH/3T3 and C6 lysates.
偶联	Unconjugated

产品属性

克隆类型	单克隆抗体
克隆号	CHSMIX
Format	Whole IgG
SDS-PAGE	150 kDa
纯化方法	Immunogen affinity purified
物理外观	Liquid
储存缓冲液	0.42% Potassium phosphate, 0.87% Sodium chloride, 30% Glycerol, 0.01% Sodium azide, pH 7.3.
防腐剂	0.01% Sodium azide
浓度	见COA
储存温度	-20°C储存,避免反复冻融
运输条件	超低温冰袋运输
稳定性与储存	4°C 短期储存（1-2 周）。-20°C下长期保存（12个月）。收货后建议分装。避免冷冻/解冻循环。
分子类型	抗体

图片

Western Blot: beta III Tubulin Mouse mAb (Ab091155)

beta III Tubulin Mouse mAb (Ab091155) - Western Blot
All lanes: beta III Tubulin Mouse mAb (Ab091155) at 1/2000 dilution
Samples: Lysates at 20 µg per lane
Secondary: Goat Anti-Mouse IgG H&L (HRP) (Ab179001) at 1/20000 dilution
Predicted band size: 50 kDa
Observed band size: 51 kDa
Exposure time: 9.3 s