货号 (SKU)

包装规格

是否现货

价格

数量

Ab005456-10μg

10μg

现货

Ab005456-50μg

50μg

现货

Ab005456-100μg

100μg

现货

Ab005456-1mg

1mg

期货

基本信息

产品名称	Myeloperoxidase Mouse mAb
别名	髓过氧化物酶小鼠单克隆抗体 \| 髓过氧化物酶小鼠单抗
英文别名	EC 1.11.2.2 \| MPO
规格或纯度	无载体, ExactAb™, 无叠氮钠, 已验证, 见COA
宿主种属	小鼠(Mouse)
特异性	MPO
种属反应性	人(Human)
免疫原	Recombinant Human Myeloperoxidase (MPO)
偶联	Unconjugated

产品属性

克隆类型	单克隆抗体
克隆号	4D12-3
Format	Whole IgG
亚型	Mouse IgG2a
轻链亚型	kappa
SDS-PAGE	150 kDa
纯化方法	Affinity chromatography
配对抗体	[Ab005457] Monoclonal Myeloperoxidase Antibody as Detection antibody in ELISA, CLIA, LF, GICA, FIA, LETIA
物理外观	Liquid
储存缓冲液	10mM PBS, pH7.4
防腐剂	No
浓度	见COA
储存温度	-20°C储存,避免反复冻融
运输条件	超低温冰袋运输
稳定性与储存	Store at 37°C short term（7 days）Store at 4°C short term（30 days）. Store at -20±5°C long term (36 months). Upon delivery aliquot. Avoid freeze/thaw cycle.
分子类型	抗体

图片

Binding ELISA - Myeloperoxidase Mouse mAb (Ab005456)

Binding ELISA - Myeloperoxidase Mouse mAb (Ab005456)
Immobilized Recombinant Human Myeloperoxidase Protein at 1.0 μg/mL can bind Myeloperoxidase Mouse mAb (Ab005456) with the EC₅₀ of 9.8 ng/mL.

Relevance of detection results between aladdin Antibody Pair (Ab005456 & Ab005457) and ReLIA in CLIA

Relevance of detection results between aladdin Antibody Pair (Ab005456 & Ab005457) and ReLIA in CLIA
·Capture antibody: Myeloperoxidase Mouse mAb (Ab005456)
·Detection antibody: Myeloperoxidase Mouse mAb (Ab005457)

SDS-PAGE: Myeloperoxidase Mouse mAb (Ab005456)

Myeloperoxidase Mouse mAb (Ab005456) - SDS-PAGE
3 μg/lane of Myeloperoxidase Mouse mAb (Ab005456) was resolved with SDS-PAGE under reducing (R) and non-reducing (N) conditions and visualized by Coomassie® Blue staining, showing the band at 25.1 kDa (Light Chain) & 51.7 kDa (Heavy Chain) under reducing conditions and 164.8 kDa under non-reducing conditions.

关联靶点（人）

MPO Tchem 髓过氧化物酶(Myeloperoxidase) (0 活性数据)

点击查看靶蛋白信息： MPO

活性类型	活性值-log(M)	作用机制	期刊	参考文献(PubMed IDs)

作用机制

作用机制	Action Type	target ID	Target Name	Target Type	Target Organism	Binding Site Name	参考文献

安全和危险性（GHS）

SDS英文版

质量标准

质量标准

应用

应用名称	稀释比例
CLIA	20µg/2mg magnetic beads
FLFIA	Fluorescent beads/Antibody = 10/1

质检证书（CoA,COO,BSE/TSE 和分析图谱)

C of A & Other Certificates(BSE/TSE, COO):

输入批号以搜索分析图谱:

通过匹配包装上的批号来查找并下载产品的 COA，每批产品都进行了严格的验证，您可放心使用！

找到3个结果

批号(Lot Number)	证书类型	日期	货号
ZJ24F1011922	分析证书	24-10-12	Ab005456
ZJ23F1001300	分析证书	23-10-13	Ab005456
ZJ23F1001303	分析证书	23-10-13	Ab005456

可替换产品

参考文献

1. Tidén AK, Sjögren T, Svensson M, Bernlind A, Senthilmohan R, Auchère F, Norman H, Markgren PO, Gustavsson S, Schmidt S et al.. (2011) 2-thioxanthines are mechanism-based inactivators of myeloperoxidase that block oxidative stress during inflammation.. J Biol Chem, 286 (43): (37578-89). [PMID:21880720]
2. Laleu B, Gaggini F, Orchard M, Fioraso-Cartier L, Cagnon L, Houngninou-Molango S, Gradia A, Duboux G, Merlot C, Heitz F et al.. (2010) First in class, potent, and orally bioavailable NADPH oxidase isoform 4 (Nox4) inhibitors for the treatment of idiopathic pulmonary fibrosis.. J Med Chem, 53 (21): (7715-30). [PMID:20942471]
3. Gan LM, Lagerström-Fermér M, Ericsson H, Nelander K, Lindstedt EL, Michaëlsson E, Kjaer M, Heijer M, Whatling C, Fuhr R. (2019) Safety, tolerability, pharmacokinetics and effect on serum uric acid of the myeloperoxidase inhibitor AZD4831 in a randomized, placebo-controlled, phase I study in healthy volunteers.. Br J Clin Pharmacol, 85 (4): (762-770). [PMID:30618054]
4. Thomas R Burkard,Melanie Planyavsky,Ines Kaupe,Florian P Breitwieser,Tilmann Bürckstümmer,Keiryn L Bennett,Giulio Superti-Furga,Jacques Colinge. (2011-01-29) Initial characterization of the human central proteome.. BMC systems biology, 5 (17-17). [PMID:21269460]
5. Roth A, Ott S, Farber KM, Palazzo TA, Conrad WE, Haddadin MJ, Tantillo DJ, Cross CE, Eiserich JP, Kurth MJ.. (2014) Inhibition of myeloperoxidase: evaluation of 2H-indazoles and 1H-indazolones.. Bioorg Med Chem, 22 (22): (6422-6429). [PMID:25438766] [10.1016/j.bmc.2014.09.044]
6. Taylor, K L KL, Pohl, J J and Kinkade, J M JM.. (1992) Unique autolytic cleavage of human myeloperoxidase. Implications for the involvement of active site MET409.. The Journal of biological chemistry, (15): [PMID:1334087]
7. Yamada, M M, Hur, S J SJ and Toda, H H.. (1990) Isolation and characterization of extracellular myeloperoxidase precursor in HL-60 cell cultures.. Biochemical and biophysical research communications, (30): [PMID:2154223]
8. Morishita, K K, Tsuchiya, M M, Asano, S S, Kaziro, Y Y and Nagata, S S.. (1987) Chromosomal gene structure of human myeloperoxidase and regulation of its expression by granulocyte colony-stimulating factor.. The Journal of biological chemistry, (5): [PMID:2444596]
9. Johnson, K K, Gemperlein, I I, Hudson, S S, Shane, S S and Rovera, G G.. (1989) Complete nucleotide sequence of the human myeloperoxidase gene.. Nucleic acids research, (11): [PMID:2552418]
10. Yamada, M M and 7 more authors.. (1987) Isolation and characterization of a cDNA coding for human myeloperoxidase.. Archives of biochemistry and biophysics, (15): [PMID:2884926]
11. Hashinaka, K K and 5 more authors.. (1988) Multiple species of myeloperoxidase messenger RNAs produced by alternative splicing and differential polyadenylation.. Biochemistry, (9): [PMID:2903767]
12. Morishita, K K, Kubota, N N, Asano, S S, Kaziro, Y Y and Nagata, S S.. (1987) Molecular cloning and characterization of cDNA for human myeloperoxidase.. The Journal of biological chemistry, (15): [PMID:3029127]
13. Johnson, K R KR and 9 more authors.. (1987) Characterization of cDNA clones for human myeloperoxidase: predicted amino acid sequence and evidence for multiple mRNA species.. Nucleic acids research, (11): [PMID:3031585]
14. Seto, P P and 6 more authors.. (1987) Isolation of a complementary DNA clone for thyroid microsomal antigen. Homology with the gene for thyroid peroxidase.. The Journal of clinical investigation, [PMID:3654979]
15. Fenna, R R, Zeng, J J and Davey, C C.. (1995) Structure of the green heme in myeloperoxidase.. Archives of biochemistry and biophysics, (10): [PMID:7840679]
16. Nauseef, W M WM, Brigham, S S and Cogley, M M.. (1994) Hereditary myeloperoxidase deficiency due to a missense mutation of arginine 569 to tryptophan.. The Journal of biological chemistry, (14): [PMID:7904599]
17. Kizaki, M M, Miller, C W CW, Selsted, M E ME and Koeffler, H P HP.. (1994) Myeloperoxidase (MPO) gene mutation in hereditary MPO deficiency.. Blood, (1): [PMID:8142659]
18. Hosokawa, Y Y and 7 more authors.. (1993) Cloning and characterization of four types of cDNA encoding myeloperoxidase from human monocytic leukemia cell line, SKM-1.. Leukemia, [PMID:8383257]
19. Yamada, M M, Yoshida, M M and Hashinaka, K K.. (1993) Identification of transcriptional cis-elements in introns 7 and 9 of the myeloperoxidase gene.. The Journal of biological chemistry, (25): [PMID:8390465]
20. Nauseef, W M WM, Cogley, M M and McCormick, S S.. (1996) Effect of the R569W missense mutation on the biosynthesis of myeloperoxidase.. The Journal of biological chemistry, (19): [PMID:8621627]
21. Romano, M M and 5 more authors.. (1997) Biochemical and molecular characterization of hereditary myeloperoxidase deficiency.. Blood, (15): [PMID:9354683]
22. DeLeo, F R FR, Goedken, M M, McCormick, S J SJ and Nauseef, W M WM.. (1998) A novel form of hereditary myeloperoxidase deficiency linked to endoplasmic reticulum/proteasome degradation.. The Journal of clinical investigation, (15): [PMID:9637725]
23. Fiedler, T J TJ, Davey, C A CA and Fenna, R E RE.. (2000) X-ray crystal structure and characterization of halide-binding sites of human myeloperoxidase at 1.8 A resolution.. The Journal of biological chemistry, (21): [PMID:10766826]
24. Liu, Tao T and 6 more authors.. Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry.. Journal of proteome research, [PMID:16335952]
25. Obach, R Scott RS and Dalvie, Deepak K DK.. (2006) Metabolism of nomifensine to a dihydroisoquinolinium ion metabolite by human myeloperoxidase, hemoglobin, monoamine oxidase A, and cytochrome P450 enzymes.. Drug metabolism and disposition: the biological fate of chemicals, [PMID:16679384]
26. Ramachandran, Prasanna P and 5 more authors.. (2006) Identification of N-linked glycoproteins in human saliva by glycoprotein capture and mass spectrometry.. Journal of proteome research, [PMID:16740002]
27. Sjöblom, Tobias T and 28 more authors.. (2006) The consensus coding sequences of human breast and colorectal cancers.. Science (New York, N.Y.), (13): [PMID:16959974]
28. Nandi, Jyotirmoy J, Saud, Bipin B, Zinkievich, J Michael JM, Palma, David T DT and Levine, Robert A RA.. (2008) 5-aminosalicylic acid improves indomethacin-induced enteropathy by inhibiting iNOS transcription in rats.. Digestive diseases and sciences, [PMID:17503181]
29. Galijasevic, Semira S, Abdulhamid, Ibrahim I and Abu-Soud, Husam M HM.. (2008) Melatonin is a potent inhibitor for myeloperoxidase.. Biochemistry, (26): [PMID:18237195]
30. Van Antwerpen, Pierre P and 14 more authors.. (2010) Glycosylation pattern of mature dimeric leukocyte and recombinant monomeric myeloperoxidase: glycosylation is required for optimal enzymatic activity.. The Journal of biological chemistry, (21): [PMID:20332087]
31. Cederlund, Martin M, Deronic, Adnan A, Pallon, Jan J, Sørensen, Ole E OE and Åkerström, Bo B.. (2015) A1M/α1-microglobulin is proteolytically activated by myeloperoxidase, binds its heme group and inhibits low density lipoprotein oxidation.. Frontiers in physiology, [PMID:25698971]

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质量

浓度

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g/mol

稀释计算器

计算配制储备溶液所需的稀释度。

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体积 1 (V1)

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复溶计算器

复溶计算器允许您快速计算试剂的体积，以复溶小瓶。只需输入试剂的质量和目标浓度，计算器将确定其余部分。

体积（添加到小瓶中）

质量（小瓶）

所需的复溶浓度

Myeloperoxidase Mouse mAb

库存信息

库存信息

库存信息

库存信息

基本信息

产品属性

图片

关联靶点（人）

作用机制

安全和危险性（GHS）

质量标准

应用

质检证书（CoA,COO,BSE/TSE 和分析图谱)

可替换产品

参考文献

溶液计算器

摩尔浓度计算器

稀释计算器

复溶计算器

Myeloperoxidase Mouse mAb

库存信息

库存信息

库存信息

库存信息

基本信息

产品属性

图片

关联靶点（人）

作用机制

安全和危险性（GHS）

质量标准

应用

质检证书（CoA,COO,BSE/TSE 和分析图谱)

相关产品

可替换产品

参考文献

溶液计算器

摩尔浓度计算器

稀释计算器

复溶计算器