基本描述

别名	生物素N-羟基琥珀酰亚胺酯 \| 生物素N-羟基琥珀酰亚胺酯 \| (+)-生物素N-羟基琥珀酰亚胺酯 \| N-羟基琥珀酰亚胺生物素 \| 生物素-N-羟基琥珀酰亚胺 \| NHS-生物素, (+)-生物素N-琥珀酰亚胺酯 \| N-琥珀酰亚胺基D-生物素 \| N-琥珀酰亚胺基D-生物素 \| N-(D-生物素基氧基)琥珀酰亚胺 \| (+)-生物素 N-琥珀酰亚胺酯 \| 阿拉丁™ NHS-生物素
英文别名	(+)-Biotin N-succinimidyl ester \| D-Biotin N-Succinimidyl Ester \| Biotin-NHS ester \| Biotin N-Hydroxysuccinimide Ester \| Biotin-NHS \| (+)-Biotin N-hydroxysuccinimide ester \| Biotin-Osu \| (+)-Biotin-NHS ester \| N-Succinimidyl D-biotinate \| N-Hydroxysuccini
规格或纯度	≥99%
英文名称	Aladdin™ NHS-Biotin
储存温度	-20°C储存,充氩,干燥
运输条件	超低温冰袋运输
产品介绍	N-羟基琥珀酰亚胺酯（NHS）生物素修饰有助于目标赖氨酸残基在ε-氨基上的生物素化，并识别表面赖氨酸残基。它被用作识别蛋白质与几种生物分子相互作用的工具，如蛋白质-多糖相互作用、蛋白质-蛋白质相互作用、蛋白质-核酸相互作用和蛋白质-配体相互作用。NHS-生物素可用于蛋白和肽的生物素化。它通常在6.5-8.5的pH范围内通常偶联至伯胺。 Product introduction： The N-hydroxysuccinimide ester (NHS)-biotin modification helps in the biotinylation of the target lysine residue at its ε-amino group and identifies the surface lysine residues. It is used as a tool to identify the interaction of proteins with several biological molecules, like protein-polysaccharide interactions, protein-protein interactions, protein-nucleic acid interactions, and protein-ligand interactions. NHS-biotin may be used in the biotinylation of proteins and peptides. It is typically coupled to primary amine in the pH range of 6.5-8.5.

作用机制

作用机制	Action Type	target ID	Target Name	Target Type	Target Organism	Binding Site Name	参考文献

名称和识别符

分子类型	小分子
IUPAC Name	(2,5-dioxopyrrolidin-1-yl) 5-[(3aS,4S,6aR)-2-oxo-1,3,3a,4,6,6a-hexahydrothieno[3,4-d]imidazol-4-yl]pentanoate
INCHI	InChI=1S/C14H19N3O5S/c18-10-5-6-11(19)17(10)22-12(20)4-2-1-3-9-13-8(7-23-9)15-14(21)16-13/h8-9,13H,1-7H2,(H2,15,16,21)/t8-,9-,13-/m0/s1
InChi Key	YMXHPSHLTSZXKH-RVBZMBCESA-N
Canonical SMILES	C1CC(=O)N(C1=O)OC(=O)CCCCC2C3C(CS2)NC(=O)N3
Isomeric SMILES	C1CC(=O)N(C1=O)OC(=O)CCCC[C@H]2[C@@H]3[C@H](CS2)NC(=O)N3
WGK Germany	3
PubChem CID	6710714
分子量	341.38
Beilstein号	4720781
Reaxy-Rn	4720781

化学和物理性质

溶解性	DMF(Dimethylformamide),DMSO(Dimethylsulfoxide)
敏感性	对湿度敏感；对空气敏感；对热敏感
熔点	140°C
分子量	341.380 g/mol
XLogP3	-0.200
氢键供体数Hydrogen Bond Donor Count	2
氢键受体数Hydrogen Bond Acceptor Count	6
可旋转键计数Rotatable Bond Count	7
精确质量Exact Mass	341.105 Da
单同位素质量Monoisotopic Mass	341.105 Da
拓扑极表面积Topological Polar Surface Area	130.000 Å²
重原子数Heavy Atom Count	23
形式电荷Formal Charge	0
复杂度Complexity	525.000
同位素原子数Isotope Atom Count	0
定义的原子立体中心计数Defined Atom Stereocenter Count	3
未定义的原子立体中心计数Undefined Atom Stereocenter Count	0
定义的键立体中心计数Defined Bond Stereocenter Count	0
未定义的键立体中心计数Undefined Bond Stereocenter Count	0
所有立体化学键的总数The total count of all stereochemical bonds	0
共价键合单元计数Covalently-Bonded Unit Count	1

安全和危险性（GHS）

象形图	GHS07
信号词	Warning
危险声明	H315: 引起皮肤刺激 H319: 引起严重眼睛刺激 H335: 可能引起呼吸道刺激
预防措施声明	P261: 避免吸入灰尘/烟雾/气体/雾/蒸汽/喷雾 P305+P351+P338: 如进入眼睛：用水小心冲洗几分钟。如戴隐形眼镜并可方便地取出，取出隐形眼镜。继续冲洗。 P280: 戴防护手套/穿防护服/戴防护眼罩/戴防护面具。 P302+P352: 如皮肤沾染：用水充分清洗。 P321: 特殊处理（请参阅此标签上的...）。 P405: 密闭存放 P501: 将内容物/容器处理到。。。 P264: 处理后要彻底洗手。 P271: 仅在室外或通风良好的地方使用。 P304+P340: 如误吸入：将人转移到空气新鲜处，保持呼吸舒适体位。 P403+P233: 存放在通风良好的地方。保持容器密闭。 P362+P364: 脱掉沾污的衣服，清洗后方可重新使用。 P264+P265: 处理后彻底洗手[和…]。不要触摸眼睛。 P337+P317: 如果眼睛刺激持续：寻求医疗帮助。 P332+P317: 如果出现皮肤刺激：请寻求医疗帮助。 P319: 如果你感到不适，请寻求医疗帮助。
WGK Germany	3
Reaxy-Rn	4720781
个人防护装备	Eyeshields,Gloves,type N95 (US),type P1 (EN143) respirator filter

SDS英文版

质量标准

Appearance(A638743)	White to Off-White Powder
Proton NMR spectrum	Conforms to Structure
Purity(HPLC)	99-100（%）
Solubility in DMF,Colorless to Faint Yellow,Clear,50mg/ml	Pass
LC-MS for identification	Conforms

质量标准

质检证书（CoA,COO,BSE/TSE 和分析图谱)

C of A & Other Certificates(BSE/TSE, COO):

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找到2个结果

批号(Lot Number)	证书类型	日期	货号
F2426271	分析证书	24-07-04	A638743
F2417102	分析证书	24-06-25	A638743

此产品的引用文献

如何在您的发表作品中引用阿拉丁的产品和网站?

1. Jiawei Huo, Jie Li, Yang Liu, Libin Yang, Xinran Cao, Chong Zhao, Yicheng Lu, Wei Zhou, Shumu Li, Jianan Liu, Jiao Li, Xing Li, Jing Wan, Rui Wen, Mingming Zhen, Chunru Wang, Chunli Bai. (2022) Amphiphilic Aminated Derivatives of [60]Fullerene as Potent Inhibitors of Tumor Growth and Metastasis. Advanced Science, 9 (29): (2201541). [PMID:36031401] [10.1002/advs.202201541]
2. Runxuan Zhang, Tao Liao, Xiao Wang, Hong Zhai, Di Yang, Xin Wang, Haiyan Wang, Feng Feng. (2022) Second near-infrared fluorescent dye for lateral flow immunoassays rapid detection of influenza A/B virus. ANALYTICAL BIOCHEMISTRY, 655 (114847). [PMID:35964731] [10.1016/j.ab.2022.114847]
3. Lingling Pan, Dawei Jiang, Luqi Pan, Zhizhen Meng, Yangyang Zhuang, Yueyue Huang, Fanrong Ye, Changcan Shi, Jie Chen, Jingye Pan. (2022) ICAM-1-targeted and antibacterial peptide modified polymeric nanoparticles for specific combating sepsis. MATERIALS & DESIGN, 222 (111007). [10.1016/j.matdes.2022.111007]
4. Fengchun Zhao, Yuan Tian, Qiang Shen, Ruxia Liu, Ruirui Shi, Huimin Wang, Zhengyou Yang. (2019) A novel nanobody and mimotope based immunoassay for rapid analysis of aflatoxin B1. TALANTA, 195 (55). [PMID:30625581] [10.1016/j.talanta.2018.11.013]
5. Lian Xu, Zhi-Zhen Pan, Jing Zhang, Li-Yang Niu, Jie Li, Zheng Chen, Bo Liu, Yu-Jing Zhu, Qing-Xi Chen. (2018) Exposure of helices α4 and α5 is required for insecticidal activity of Cry2Ab by promoting assembly of a prepore oligomeric structure. CELLULAR MICROBIOLOGY, 20 (6): (e12827). [PMID:29380507] [10.1111/cmi.12827]
6. Fengchun Zhao, Qiang Shen, Huimin Wang, Xiao Han, Zhengyou Yang. (2017) Development of a rapid magnetic bead-based immunoassay for sensitive detection of zearalenone. FOOD CONTROL, 79 (227). [10.1016/j.foodcont.2017.03.051]
7. Yu Li, Ying Chen, Dongmei Deng, Liqiang Luo, Haibo He, Zhenxin Wang. (2017) Water-dispersible graphene/amphiphilic pyrene derivative nanocomposite: High AuNPs loading capacity for CEA electrochemical immunosensing. SENSORS AND ACTUATORS B-CHEMICAL, 248 (966). [10.1016/j.snb.2017.02.138]
8. Yu Li, Qi Wang, Yuting Zhang, Dongmei Deng, Haibo He, Liqiang Luo, Zhenxin Wang. (2016) A label-free electrochemical aptasensor based on graphene oxide/double-stranded DNA nanocomposite. COLLOIDS AND SURFACES B-BIOINTERFACES, 145 (160). [PMID:27182650] [10.1016/j.colsurfb.2016.04.048]

参考文献

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2. Pak JS, DeLoughery ZJ, Wang J, Acharya N, Park Y, Jaworski A, Özkan E. NELL2-Robo3 complex structure reveals mechanisms of receptor activation for axon guidance.. Nat Commun, [PMID:32198364]
3. Zeng W, Niu L, Wang Z, Wang X, Wang Y, Pan L, Lu Z, Cui G, Weng W, Wang M, Meng X, Wang Z. Application of an antibody chip for screening differentially expressed proteins during peach ripening and identification of a metabolon in the SAM cycle to generate a peach ethylene biosynthesis model.. Hortic Res, [PMID:32194967]
4. Tharp JM, Hampton JT, Reed CA, Ehnbom A, Chen PC, Morse JS, Kurra Y, Pérez LM, Xu S, Liu WR. An amber obligate active site-directed ligand evolution technique for phage display.. Nat Commun, [PMID:32170178]
5. Zhang C, He T, Vedadghavami A, Bajpayee AG. Avidin-biotin technology to synthesize multi-arm nano-construct for drug delivery.. MethodsX, [PMID:32405463]
6. Ohlendorf R, Wisniowska A, Desai M, Barandov A, Slusarczyk AL, Li N, Jasanoff A. Target-responsive vasoactive probes for ultrasensitive molecular imaging.. Nat Commun, [PMID:32404879]
7. Seo JA, Kang MC, Yang WM, Hwang WM, Kim SS, Hong SH, Heo JI, Vijyakumar A, Pereira de Moura L, Uner A, Huang H, Lee SH, Lima IS, Park KS, Kim MS, Dagon Y, Willnow TE, Aroda V, Ciaraldi TP, Henry RR, Kim YB. Apolipoprotein\xa0J is a hepatokine regulating muscle glucose metabolism and insulin sensitivity.. Nat Commun, [PMID:32332780]
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9. Wang JJ, Liu F, Yang F, Wang YZ, Qi X, Li Y, Hu Q, Zhu MX, Xu TL. (2020) Disruption of auto-inhibition underlies conformational signaling of ASIC1a to induce neuronal necroptosis.. Nat Commun, 11 (1): (475). [PMID:31980622]
10. Rao L, Hülsemann M, Gennerich A. Combining Structure-Function and Single-Molecule Studies on Cytoplasmic Dynein.. Methods Mol Biol, [PMID:28940064]
11. Cardote TAF, Gadd MS, Ciulli A. Crystal Structure of the Cul2-Rbx1-EloBC-VHL Ubiquitin Ligase Complex.. Structure, [PMID:28591624]
12. Brouillette RB, Phillips EK, Ayithan N, Maury W. Differences in Glycoprotein Complex Receptor Binding Site Accessibility Prompt Poor Cross-Reactivity of Neutralizing Antibodies between Closely Related Arenaviruses.. J Virol, [PMID:28100617]
13. Wolhuter K, Whitwell HJ, Switzer CH, Burgoyne JR, Timms JF, Eaton P. Evidence against Stable Protein S-Nitrosylation as a Widespread Mechanism of Post-translational Regulation.. Mol Cell, [PMID:29358077]
14. Pazina T, James AM, MacFarlane AW, Bezman NA, Henning KA, Bee C, Graziano RF, Robbins MD, Cohen AD, Campbell KS. The anti-SLAMF7 antibody elotuzumab mediates NK cell activation through both CD16-dependent and -independent mechanisms.. Oncoimmunology, [PMID:28932638]
15. Diner I,Hales CM,Bishof I,Rabenold L,Duong DM,Yi H,Laur O,Gearing M,Troncoso J,Thambisetty M,Lah JJ,Levey AI,Seyfried NT. Aggregation properties of the small nuclear ribonucleoprotein U1-70K in Alzheimer disease.. [PMID:25355317]
16. Lei L, Yang YR, Tran K, Wang Y, Chiang CI, Ozorowski G, Xiao Y, Ward AB, Wyatt RT, Li Y. The HIV-1 Envelope Glycoprotein C3/V4 Region Defines a Prevalent Neutralization Epitope following Immunization.. Cell Rep, [PMID:30970260]
17. Jiawei Huo, Jie Li, Yang Liu, Libin Yang, Xinran Cao, Chong Zhao, Yicheng Lu, Wei Zhou, Shumu Li, Jianan Liu, Jiao Li, Xing Li, Jing Wan, Rui Wen, Mingming Zhen, Chunru Wang, Chunli Bai. (2022) Amphiphilic Aminated Derivatives of [60]Fullerene as Potent Inhibitors of Tumor Growth and Metastasis. Advanced Science, 9 (29): (2201541). [PMID:36031401] [10.1002/advs.202201541]
18. Runxuan Zhang, Tao Liao, Xiao Wang, Hong Zhai, Di Yang, Xin Wang, Haiyan Wang, Feng Feng. (2022) Second near-infrared fluorescent dye for lateral flow immunoassays rapid detection of influenza A/B virus. ANALYTICAL BIOCHEMISTRY, 655 (114847). [PMID:35964731] [10.1016/j.ab.2022.114847]
19. Lingling Pan, Dawei Jiang, Luqi Pan, Zhizhen Meng, Yangyang Zhuang, Yueyue Huang, Fanrong Ye, Changcan Shi, Jie Chen, Jingye Pan. (2022) ICAM-1-targeted and antibacterial peptide modified polymeric nanoparticles for specific combating sepsis. MATERIALS & DESIGN, 222 (111007). [10.1016/j.matdes.2022.111007]
20. Fengchun Zhao, Yuan Tian, Qiang Shen, Ruxia Liu, Ruirui Shi, Huimin Wang, Zhengyou Yang. (2019) A novel nanobody and mimotope based immunoassay for rapid analysis of aflatoxin B1. TALANTA, 195 (55). [PMID:30625581] [10.1016/j.talanta.2018.11.013]
21. Lian Xu, Zhi-Zhen Pan, Jing Zhang, Li-Yang Niu, Jie Li, Zheng Chen, Bo Liu, Yu-Jing Zhu, Qing-Xi Chen. (2018) Exposure of helices α4 and α5 is required for insecticidal activity of Cry2Ab by promoting assembly of a prepore oligomeric structure. CELLULAR MICROBIOLOGY, 20 (6): (e12827). [PMID:29380507] [10.1111/cmi.12827]
22. Fengchun Zhao, Qiang Shen, Huimin Wang, Xiao Han, Zhengyou Yang. (2017) Development of a rapid magnetic bead-based immunoassay for sensitive detection of zearalenone. FOOD CONTROL, 79 (227). [10.1016/j.foodcont.2017.03.051]
23. Yu Li, Ying Chen, Dongmei Deng, Liqiang Luo, Haibo He, Zhenxin Wang. (2017) Water-dispersible graphene/amphiphilic pyrene derivative nanocomposite: High AuNPs loading capacity for CEA electrochemical immunosensing. SENSORS AND ACTUATORS B-CHEMICAL, 248 (966). [10.1016/j.snb.2017.02.138]
24. Yu Li, Qi Wang, Yuting Zhang, Dongmei Deng, Haibo He, Liqiang Luo, Zhenxin Wang. (2016) A label-free electrochemical aptasensor based on graphene oxide/double-stranded DNA nanocomposite. COLLOIDS AND SURFACES B-BIOINTERFACES, 145 (160). [PMID:27182650] [10.1016/j.colsurfb.2016.04.048]

溶液计算器

摩尔浓度计算器

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稀释计算器

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复溶计算器

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货号 (SKU)	包装规格	是否现货
A638743-25mg	25mg	期货
A638743-50mg	50mg	现货
A638743-100mg	100mg	现货

Aladdin™ NHS-Biotin

库存信息

库存信息

库存信息

基本描述

作用机制

名称和识别符

化学和物理性质

安全和危险性（GHS）

质量标准

质检证书（CoA,COO,BSE/TSE 和分析图谱)

此产品的引用文献

参考文献

溶液计算器

摩尔浓度计算器

稀释计算器

复溶计算器