| 货号 (SKU) | 包装规格 | 是否现货 | 价格 | 数量 |
|---|---|---|---|---|
| A424505-1ml |
1ml |
现货  |
|
| 别名 | 二苯基硼酸 |
|---|---|
| 英文别名 | 524-95-8 | 2-Aminoethyl diphenylborinate | 2-APB | (2-Aminoethoxy)diphenylborane | 2-Aminoethoxydiphenylborane | 2-((Diphenylboryl)oxy)ethanamine | 2-aminoethoxydiphenyl borate | 2-Aminoethoxydiphenylborate | 2-diphenylboranyloxyethanamine | Borinic acid, diphenyl-, 2-amin |
| 规格或纯度 | Moligand™, 10mM in DMSO |
| 英文名称 | 2-Aminoethyl diphenylborinate |
| 生化机理 | D-肌醇1,4,5-三磷酸（IP3）的细胞渗透性变构抑制剂可诱导Ca 2+释放。抑制IP3诱导的Ca 2+释放，而不影响IP3受体结合。阻止存储操作的Ca 2+入口。 |
| 储存温度 | -80℃储存 |
| 运输条件 | 超低温冰袋运输 |
| 作用类型 | 激活剂 |
| 作用机制 | TRPC1 的通道阻断剂;TRPC3 的通道阻断剂;TRPC4 的通道阻断剂;TRPC5 的通道阻断剂;TRPC6 的通道阻断剂;TRPC7 的通道阻断剂;TRPM2 的通道阻断剂;TRPM3 的门控抑制剂；TRPM6 的激活剂;TRPM7 的激活剂;TRPM7 的通道阻断剂;TRPM8 的通道阻断剂;TRPV1 的激活剂;TRPV1 的通道阻断剂;TRPV2 的激活剂;TRPV3 的激活剂;TRPV6 的激活剂 |
| 产品介绍 |
2-APB is a transient receptor potential (TRP) activator. The compound also directly blocks the mitochondrial permeability transition pore, sarco/endoplasmic reticulum Ca2+-ATPase pumps, and native store operated channels, as well as other ion channels. 2-APB does not activate the subfamily transient receptor potential vanilloids (TRPVs) TRPV4, TRPV5, and TRPV6, but can activate VR1 (TRPV1), VRL-1 (TRPV2), and TRPV3. 2-ABP was first used as an inhibitor of IP3R (inositol 1,4,5-triphosphate receptor) with the ability to permeate the membrane. 2-ABP can induce Ca2+entry without activating exocytosis. In pancreatic acinar cells 2-ABP can inhibit calcium mobilization. 2-APB is an activator of Orai3. 2-APB is a transient receptor potential (TRP) activator. The compound also directly blocks the mitochondrial permeability transition pore, sarco/endoplasmic reticulum Ca2+-ATPase pumps, and native store operated channels, as well as other ion channels. 2-APB does not activate the subfamily transient receptor potential vanilloids (TRPVs) TRPV4, TRPV5, and TRPV6, but can activate VR1 (TRPV1), VRL-1 (TRPV2), and TRPV3. 2-ABP was first used as an inhibitor of IP3R (inositol 1,4,5-triphosphate receptor) with the ability to permeate the membrane. 2-ABP can induce Ca2+entry without activating exocytosis. In pancreatic acinar cells 2-ABP can inhibit calcium mobilization. 2-APB is an activator of Orai3. |
| 作用机制 | Action Type | target ID | Target Name | Target Type | Target Organism | Binding Site Name | 参考文献 |
|---|
| EC号 | 208-366-5 |
|---|---|
| 分子类型 | 小分子 |
| IUPAC Name | 2-diphenylboranyloxyethanamine |
| INCHI | InChI=1S/C14H16BNO/c16-11-12-17-15(13-7-3-1-4-8-13)14-9-5-2-6-10-14/h1-10H,11-12,16H2 |
| InChi Key | BLZVCIGGICSWIG-UHFFFAOYSA-N |
| Canonical SMILES | B(C1=CC=CC=C1)(C2=CC=CC=C2)OCCN |
| Isomeric SMILES | B(C1=CC=CC=C1)(C2=CC=CC=C2)OCCN |
| WGK Germany | 3 |
| RTECS | ED6150000 |
| PubChem CID | 1598 |
| 分子量 | 225.09 |
| Beilstein号 | 2942273 |
| Reaxy-Rn | 2942273 |
| 敏感性 | 光及湿度敏感 |
|---|---|
| 熔点 | 190-194°C |
| 分子量 | 225.100 g/mol |
| XLogP3 | |
| 氢键供体数Hydrogen Bond Donor Count | 1 |
| 氢键受体数Hydrogen Bond Acceptor Count | 2 |
| 可旋转键计数Rotatable Bond Count | 5 |
| 精确质量Exact Mass | 225.132 Da |
| 单同位素质量Monoisotopic Mass | 225.132 Da |
| 拓扑极表面积Topological Polar Surface Area | 35.300 Ų |
| 重原子数Heavy Atom Count | 17 |
| 形式电荷Formal Charge | 0 |
| 复杂度Complexity | 182.000 |
| 同位素原子数Isotope Atom Count | 0 |
| 定义的原子立体中心计数Defined Atom Stereocenter Count | 0 |
| 未定义的原子立体中心计数Undefined Atom Stereocenter Count | 0 |
| 定义的键立体中心计数Defined Bond Stereocenter Count | 0 |
| 未定义的键立体中心计数Undefined Bond Stereocenter Count | 0 |
| 所有立体化学键的总数The total count of all stereochemical bonds | 0 |
| 共价键合单元计数Covalently-Bonded Unit Count | 1 |
| 象形图 | GHS07 |
|---|---|
| 信号词 | Warning |
| 危险声明 |
H315: 引起皮肤刺激 H319: 引起严重眼睛刺激 H335: 可能引起呼吸道刺激 |
| 预防措施声明 |
P261: 避免吸入灰尘/烟雾/气体/雾/蒸汽/喷雾 P305+P351+P338: 如进入眼睛：用水小心冲洗几分钟。如戴隐形眼镜并可方便地取出，取出隐形眼镜。继续冲洗。 P280: 戴防护手套/穿防护服/戴防护眼罩/戴防护面具。 P302+P352: 如皮肤沾染：用水充分清洗。 P405: 密闭存放 P501: 将内容物/容器处理到。。。 P264: 处理后要彻底洗手。 P271: 仅在室外或通风良好的地方使用。 P304+P340: 如误吸入：将人转移到空气新鲜处，保持呼吸舒适体位。 P337+P313: 如仍觉眼刺激：求医/就诊。 P403+P233: 存放在通风良好的地方。保持容器密闭。 P332+P313: 如发生皮肤刺激：求医/就诊。 |
| WGK Germany | 3 |
| RTECS | ED6150000 |
| Reaxy-Rn | 2942273 |
| 个人防护装备 | Eyeshields,Gloves,type N95 (US),type P1 (EN143) respirator filter |
| Concentration | 9-11（mmol/L） |
|---|---|
| NMR Spectrum 1H | Conforms to Structure |
| 1. Kong Yuanyuan, Hu Xiaoli, Zhong Yingqun, Xu Ke, Wu Buling, Zheng Jianmao. (2019) Magnesium-enriched microenvironment promotes odontogenic differentiation in human dental pulp stem cells by activating ERK/BMP2/Smads signaling. Stem Cell Research & Therapy, 10 (1): (1-11). [PMID:31823825] [10.1186/s13287-019-1493-5] |
| 2. Luo M et al.. (2020) Sanguinarine Rapidly Relaxes Rat Airway Smooth Muscle Cells Dependent on TAS2R Signaling.. Biol Pharm Bull, 43 (7): (1027-1034). [PMID:32404582] |
| 1. Kong Yuanyuan, Hu Xiaoli, Zhong Yingqun, Xu Ke, Wu Buling, Zheng Jianmao. (2019) Magnesium-enriched microenvironment promotes odontogenic differentiation in human dental pulp stem cells by activating ERK/BMP2/Smads signaling. Stem Cell Research & Therapy, 10 (1): (1-11). [PMID:31823825] [10.1186/s13287-019-1493-5] |
| 2. Luo M et al.. (2020) Sanguinarine Rapidly Relaxes Rat Airway Smooth Muscle Cells Dependent on TAS2R Signaling.. Biol Pharm Bull, 43 (7): (1027-1034). [PMID:32404582] |
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