| 货号 (SKU) | 包装规格 | 是否现货 | 价格 | 数量 |
|---|---|---|---|---|
| A409287-1ml |
1ml |
现货  |
|
| 英文别名 | N-[6-(propylthio)-1H-benzimidazol-2-yl]-carbamic acid methyl ester |
|---|---|
| 规格或纯度 | 10mM in DMSO |
| 英文名称 | Albendazole (SKF-62979) |
| 生化机理 | 阿苯达唑（SKF-62979）是苯并咪唑类化合物的一种，是一种用于治疗各种虫害的药物。 |
| 储存温度 | -80℃储存 |
| 运输条件 | 超低温冰袋运输 |
| 作用类型 | 抑制剂 |
| 作用机制 | 微管蛋白抑制剂 |
| 产品介绍 |
微溶于有机溶剂，不溶于水。无臭。 该品对牛、羊肝片吸虫成虫和幼虫，大片吸虫均有效，减虫率可达90-100%，今年来，发现该品对牛囊尾蚴亦有很强的作用。此外，改频还可用于预防寄生虫的感染，因此对于促进绵羊的生长增加羊毛产量，均可收到较好的效果。 Information Albendazole (SKF-62979) is a member of the benzimidazole compounds used as a drug indicated for the treatment of a variety of worm infestations. Albendazole is reported to be teratogenic in rats, and is extensively metabolized to the sulfoxide derivative. Albendazole and its sulfoxide metabolite elicit an accumulation of cells in the mitotic phase of the cell cycle. In vivo Albendazole causes an induction of hepatic activities of CYP1A1-associated ethoxyresorufin O-deethylase (EROD) 65 fold, CYP1A2-associated methoxyresorufin O-demethylase (MROD) 6 fold, CYP2B1-associated penthoxyresorufin O-dealkylase (PROD) 4 fold, CYP2B2-associated benzyloxyresorufin O-dealkylase (BROD) 14 fold, as well as a partial reduction of CYP2E1-associated 4-nitrophenol hydroxylase (4-NPH) activity in the rat. Albendazole is metabolized to its pharmacologically active sulfoxide metabolites by liver and lung microsomes from sheep and cattle, as well as by cattle intestinal microsomes. Albendazole (ABZ) is a benzimidazole derivative with a broad spectrum of activity against human and animal helminthe parasites. Albendazole and its metabolites are extensively distributed to the digestive tract, mainly into the abomasal fluid, after the i.v. and i.r. administrations. Albendazole and its active albendazole sulphoxide (ABZSO) metabolite are recovered in tapeworms collected from both i.v. and i.r. treated lambs. cell lines： Concentrations： Incubation Time： Powder Purity:≥97% |
| 分子类型 | 小分子 |
|---|---|
| Canonical SMILES | CCCSC1=CC=C2N=C(NC(=O)OC)[NH]C2=C1 |
| 分子量 | 265.33 |
| 溶解性 | Solubility (25°C) In vitro DMSO: 97 mg/mL (201.06 mM); |
|---|
| Appearance(Colorless Transparent Liquid) | Pass |
|---|---|
| Concentration(Compounding value) | 9-11（mmol/L） |
| Record the entire process by video | Conform |
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