| 货号 (SKU) | 包装规格 | 是否现货 | 价格 | 数量 |
|---|---|---|---|---|
| A408570-1ml |
1ml |
现货  |
|
| 英文别名 | 1H-Pyrazole-1-carbothioamide, 3-(6-methyl-2-pyridinyl)-N-phenyl-4-(4-quinolinyl)- |
|---|---|
| 规格或纯度 | 10mM in DMSO |
| 英文名称 | A-83-01 |
| 生化机理 | A-83-01 是 TGF-β I 型受体（ALK5-TD）的强效抑制剂，IC50 为 12 nM。A-83-01 还能抑制活化素/结节 I 型受体（ALK4-TD）和结节 I 型受体（ALK7-TD）诱导的转录，IC50 分别为 45 nM 和 7.5 nM。 |
| 储存温度 | -80℃储存 |
| 运输条件 | 超低温冰袋运输 |
| 产品介绍 |
A 83-01 是一种有效的 TGF-β I 型受体 ALK5，ALK4 和 ALK7 的抑制剂，能够抑制 ALK5，ALK4 和 ALK7 诱导的转录，IC50 值分别为 12 nM，45 nM 和 7.5 nM。
Information A-83-01 is a potent inhibitor ofTGF-β type I receptor (ALK5-TD)with IC50 of 12 nM. A-83-01 also inhibits the transcription induced byactivin/nodal type I receptor (ALK4-TD)andnodal type I receptor (ALK7-TD)with IC50 of 45 nM and 7.5 nM, respectively.Solut A-83-01 inhibits the transcriptional activity induced by TGF-β type I receptor ALK-5 and that by activin type IB receptor ALK-4 and nodal type I receptor ALK-7, the kinase domains of which are structurally highly related to those of ALK-5. A-83-01 is potent in the inhibition of ALK5 and also prevents phosphorylation of Smad2/3 and the growth inhibition induced by TGF-β. In vivo A83-01 treatment significantly increases the number of Nkx2.5+ cardiomyoblasts at baseline and after myocardial injury, resulting in an increase in newly formed cardiomyocytes. A83-01 treatment significantly improves ventricular elastance and stroke work, leading to improved contractility after injury. cell lines： Concentrations：1 μM Incubation Time：1 h Powder Purity: |
| IC50 | ALK5, IC50: 12 nM |
|---|
| Canonical SMILES | CC1=CC=CC(=N1)C2=N[N](C=C2C3=CC=NC4=CC=CC=C34)C(=S)NC5=CC=CC=C5 |
|---|---|
| 分子量 | 421.52 |
| 溶解性 | Solubility (25°C) In vitro DMSO: 47 mg/mL (197.28 mM); |
|---|
| Concentration | |
|---|---|
| Proton NMR spectrum | Conforms to Structure |
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